Literature DB >> 25939735

S-Nitrosated Polypropylene Sulfide Nanoparticles for Thiol-Dependent Transnitrosation and Toxicity Against Adult Female Filarial Worms.

Alex Schudel1,2, Timothy Kassis2,3, J Brandon Dixon2,4,5, Susan N Thomas2,4,5,6.   

Abstract

A synthetic polymer nanoparticle formulation utilizing the physiological nitrosothiol chemistry for nitric oxide delivery is shown. Toxicity of S-nitroso nanoparticles against adult female Brugia malayi worms, which are responsible for lymphatic filariasis, is dependent on nitric oxide release through transnitrosation as S-nitrosocysteine, a potent endogenous nitric oxide donor.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  B. malayi; NO donors; nanoparticles; nitric oxide; nitrosothiol

Mesh：

Substances：

Year:  2015        PMID： 25939735      PMCID： PMC4640194          DOI： 10.1002/adhm.201400841

Source DB:  PubMed          Journal:  Adv Healthc Mater        ISSN： 2192-2640            Impact factor:   9.933


  49 in total

Review 1.  The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics.

Authors:  Jon O Lundberg; Eddie Weitzberg; Mark T Gladwin
Journal:  Nat Rev Drug Discov       Date:  2008-02       Impact factor: 84.694

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Journal:  Infect Immun       Date:  1991-09       Impact factor: 3.441

3.  Nitric oxide-induced inhibition of mouse paw edema: involvement of soluble guanylate cyclase and potassium channels.

Authors:  D Fernandes; J E Da Silva-Santos; J Assreuy
Journal:  Inflamm Res       Date:  2002-08       Impact factor: 4.575

4.  Kinetics and equilibria of S-nitrosothiol-thiol exchange between glutathione, cysteine, penicillamines and serum albumin.

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Journal:  FEBS Lett       Date:  1994-05-30       Impact factor: 4.124

Review 5.  Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide.

Authors:  D A Wink; J B Mitchell
Journal:  Free Radic Biol Med       Date:  1998-09       Impact factor: 7.376

6.  NO+, NO, and NO- donation by S-nitrosothiols: implications for regulation of physiological functions by S-nitrosylation and acceleration of disulfide formation.

Authors:  D R Arnelle; J S Stamler
Journal:  Arch Biochem Biophys       Date:  1995-04-20       Impact factor: 4.013

7.  S-nitrosothiol-modified dendrimers as nitric oxide delivery vehicles.

Authors:  Nathan A Stasko; Thomas H Fischer; Mark H Schoenfisch
Journal:  Biomacromolecules       Date:  2008-02-05       Impact factor: 6.988

8.  Chemical mechanisms underlying the vasodilator and platelet anti-aggregating properties of S-nitroso-N-acetyl-DL-penicillamine and S-nitrosoglutathione.

Authors:  S C Askew; A R Butler; F W Flitney; G D Kemp; I L Megson
Journal:  Bioorg Med Chem       Date:  1995-01       Impact factor: 3.641

9.  S-nitrosoglutathione (GSNO) is cytotoxic to intracellular amastigotes and promotes healing of topically treated Leishmania major or Leishmania braziliensis skin lesions.

Authors:  Inez Silva Fernandes Costa; Gabriela Freitas Pereira de Souza; Marcelo Ganzarolli de Oliveira; Ises de Almeida Abrahamsohn
Journal:  J Antimicrob Chemother       Date:  2013-06-19       Impact factor: 5.790

Review 10.  The NIH-NIAID Filariasis Research Reagent Resource Center.

Authors:  Michelle L Michalski; Kathryn G Griffiths; Steven A Williams; Ray M Kaplan; Andrew R Moorhead
Journal:  PLoS Negl Trop Dis       Date:  2011-11-29
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  5 in total

Review 1.  Implications of Lymphatic Transport to Lymph Nodes in Immunity and Immunotherapy.

Authors:  Susan N Thomas; Nathan A Rohner; Erin E Edwards
Journal:  Annu Rev Biomed Eng       Date:  2016-02-24       Impact factor: 9.590

2.  Winner of the society for biomaterials young investigator award for the annual meeting of the society for biomaterials, April 11-14, 2018, Atlanta, GA: S-nitrosated poly(propylene sulfide) nanoparticles for enhanced nitric oxide delivery to lymphatic tissues.

Authors:  Alex Schudel; Lauren F Sestito; Susan N Thomas
Journal:  J Biomed Mater Res A       Date:  2018-03-05       Impact factor: 4.396

3.  Synthetic/ECM-inspired hybrid platform for hollow microcarriers with ROS-triggered nanoporation hallmarks.

Authors:  Gesmi Milcovich; Paolo Contessotto; Grazia Marsico; Siti Ismail; Abhay Pandit
Journal:  Sci Rep       Date:  2017-10-13       Impact factor: 4.379

4.  Lymph-directed nitric oxide increases immune cell access to lymph-borne nanoscale solutes.

Authors:  Lauren F Sestito; Susan N Thomas
Journal:  Biomaterials       Date:  2020-09-18       Impact factor: 12.479

5.  Programmable multistage drug delivery to lymph nodes.

Authors:  Alex Schudel; Asheley Poole Chapman; Mei-Kwan Yau; Cody James Higginson; David Mark Francis; Margaret Patricia Manspeaker; Alexa Regina Chua Avecilla; Nathan Andrew Rohner; M G Finn; Susan Napier Thomas
Journal:  Nat Nanotechnol       Date:  2020-06-10       Impact factor: 40.523
  5 in total

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