Literature DB >> 18794857

Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.

Anne Barton1, Wendy Thomson, Xiayi Ke, Steve Eyre, Anne Hinks, John Bowes, Darren Plant, Laura J Gibbons, Anthony G Wilson, Deborah E Bax, Ann W Morgan, Paul Emery, Sophia Steer, Lynne Hocking, David M Reid, Paul Wordsworth, Pille Harrison, Jane Worthington.   

Abstract

The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

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Mesh：

Year:  2008        PMID： 18794857      PMCID： PMC2662493          DOI： 10.1038/ng.218

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  12 in total

Review 1.  Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1.

Authors:  Hiroaki Niiro; Edward A Clark
Journal:  Immunity       Date:  2003-11       Impact factor: 31.745

2.  Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.

Authors:  Robert M Plenge; Chris Cotsapas; Leela Davies; Alkes L Price; Paul I W de Bakker; Julian Maller; Itsik Pe'er; Noel P Burtt; Brendan Blumenstiel; Matt DeFelice; Melissa Parkin; Rachel Barry; Wendy Winslow; Claire Healy; Robert R Graham; Benjamin M Neale; Elena Izmailova; Ronenn Roubenoff; Alexander N Parker; Roberta Glass; Elizabeth W Karlson; Nancy Maher; David A Hafler; David M Lee; Michael F Seldin; Elaine F Remmers; Annette T Lee; Leonid Padyukov; Lars Alfredsson; Jonathan Coblyn; Michael E Weinblatt; Stacey B Gabriel; Shaun Purcell; Lars Klareskog; Peter K Gregersen; Nancy A Shadick; Mark J Daly; David Altshuler
Journal:  Nat Genet       Date:  2007-11-04       Impact factor: 38.330

Review 3.  Both integrated and differential regulation of components of the IL-2/IL-2 receptor system.

Authors:  Hyoung Pyo Kim; Jean Imbert; Warren J Leonard
Journal:  Cytokine Growth Factor Rev       Date:  2006-09-05       Impact factor: 7.638

4.  Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins.

Authors:  Tom W J Huizinga; Christopher I Amos; Annette H M van der Helm-van Mil; Wei Chen; Floris A van Gaalen; Damini Jawaheer; Geziena M T Schreuder; Mark Wener; Ferdinand C Breedveld; Naila Ahmad; Raymond F Lum; Rene R P de Vries; Peter K Gregersen; Rene E M Toes; Lindsey A Criswell
Journal:  Arthritis Rheum       Date:  2005-11

5.  Identification of a distal STAT5-binding DNA region that may mediate growth hormone regulation of insulin-like growth factor-I gene expression.

Authors:  Ying Wang; Honglin Jiang
Journal:  J Biol Chem       Date:  2005-01-27       Impact factor: 5.157

Review 6.  Evidence of kinesin heavy chain (KIF5A) involvement in pure hereditary spastic paraplegia.

Authors:  M Fichera; M Lo Giudice; M Falco; M Sturnio; S Amata; O Calabrese; S Bigoni; E Calzolari; M Neri
Journal:  Neurology       Date:  2004-09-28       Impact factor: 9.910

7.  Rheumatoid arthritis association at 6q23.

Authors:  Wendy Thomson; Anne Barton; Xiayi Ke; Steve Eyre; Anne Hinks; John Bowes; Rachelle Donn; Deborah Symmons; Samantha Hider; Ian N Bruce; Anthony G Wilson; Ioanna Marinou; Ann Morgan; Paul Emery; Angela Carter; Sophia Steer; Lynne Hocking; David M Reid; Paul Wordsworth; Pille Harrison; David Strachan; Jane Worthington
Journal:  Nat Genet       Date:  2007-11-04       Impact factor: 38.330

8.  Common variants at CD40 and other loci confer risk of rheumatoid arthritis.

Authors:  Soumya Raychaudhuri; Elaine F Remmers; Annette T Lee; Rachel Hackett; Candace Guiducci; Noël P Burtt; Lauren Gianniny; Benjamin D Korman; Leonid Padyukov; Fina A S Kurreeman; Monica Chang; Joseph J Catanese; Bo Ding; Sandra Wong; Annette H M van der Helm-van Mil; Benjamin M Neale; Jonathan Coblyn; Jing Cui; Paul P Tak; Gert Jan Wolbink; J Bart A Crusius; Irene E van der Horst-Bruinsma; Lindsey A Criswell; Christopher I Amos; Michael F Seldin; Daniel L Kastner; Kristin G Ardlie; Lars Alfredsson; Karen H Costenbader; David Altshuler; Tom W J Huizinga; Nancy A Shadick; Michael E Weinblatt; Niek de Vries; Jane Worthington; Mark Seielstad; Rene E M Toes; Elizabeth W Karlson; Ann B Begovich; Lars Klareskog; Peter K Gregersen; Mark J Daly; Robert M Plenge
Journal:  Nat Genet       Date:  2008-09-14       Impact factor: 38.330

9.  Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

Authors: 
Journal:  Nature       Date:  2007-06-07       Impact factor: 49.962

10.  Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility.

Authors:  Anne Barton; Wendy Thomson; Xiayi Ke; Steve Eyre; Anne Hinks; John Bowes; Laura Gibbons; Darren Plant; Anthony G Wilson; Ioanna Marinou; Ann Morgan; Paul Emery; Sophia Steer; Lynne Hocking; David M Reid; Paul Wordsworth; Pille Harrison; Jane Worthington
Journal:  Hum Mol Genet       Date:  2008-04-22       Impact factor: 6.150
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  69 in total

1.  Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

Authors:  Eli A Stahl; Soumya Raychaudhuri; Elaine F Remmers; Gang Xie; Stephen Eyre; Brian P Thomson; Yonghong Li; Fina A S Kurreeman; Alexandra Zhernakova; Anne Hinks; Candace Guiducci; Robert Chen; Lars Alfredsson; Christopher I Amos; Kristin G Ardlie; Anne Barton; John Bowes; Elisabeth Brouwer; Noel P Burtt; Joseph J Catanese; Jonathan Coblyn; Marieke J H Coenen; Karen H Costenbader; Lindsey A Criswell; J Bart A Crusius; Jing Cui; Paul I W de Bakker; Philip L De Jager; Bo Ding; Paul Emery; Edward Flynn; Pille Harrison; Lynne J Hocking; Tom W J Huizinga; Daniel L Kastner; Xiayi Ke; Annette T Lee; Xiangdong Liu; Paul Martin; Ann W Morgan; Leonid Padyukov; Marcel D Posthumus; Timothy R D J Radstake; David M Reid; Mark Seielstad; Michael F Seldin; Nancy A Shadick; Sophia Steer; Paul P Tak; Wendy Thomson; Annette H M van der Helm-van Mil; Irene E van der Horst-Bruinsma; C Ellen van der Schoot; Piet L C M van Riel; Michael E Weinblatt; Anthony G Wilson; Gert Jan Wolbink; B Paul Wordsworth; Cisca Wijmenga; Elizabeth W Karlson; Rene E M Toes; Niek de Vries; Ann B Begovich; Jane Worthington; Katherine A Siminovitch; Peter K Gregersen; Lars Klareskog; Robert M Plenge
Journal:  Nat Genet       Date:  2010-05-09       Impact factor: 38.330

2.  Locus category based analysis of a large genome-wide association study of rheumatoid arthritis.

Authors:  Jan Freudenberg; Annette T Lee; Katherine A Siminovitch; Christopher I Amos; David Ballard; Wentian Li; Peter K Gregersen
Journal:  Hum Mol Genet       Date:  2010-07-16       Impact factor: 6.150

3.  Interleukin-2 Receptor β Thr-450 Phosphorylation Is a Positive Regulator for Receptor Complex Stability and Activation of Signaling Molecules.

Authors:  Blanca E Ruiz-Medina; Jeremy A Ross; Robert A Kirken
Journal:  J Biol Chem       Date:  2015-07-07       Impact factor: 5.157

4.  Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.

Authors: 
Journal:  Nat Genet       Date:  2009-06-14       Impact factor: 38.330

5.  [Familial clustering, genetic roots and insights into the pathogenesis of autoimmune diseases].

Authors:  M Pierer; C Baerwald; U Wagner
Journal:  Z Rheumatol       Date:  2009-11       Impact factor: 1.372

Review 6.  The genetics revolution in rheumatology: large scale genomic arrays and genetic mapping.

Authors:  Stephen Eyre; Gisela Orozco; Jane Worthington
Journal:  Nat Rev Rheumatol       Date:  2017-06-01       Impact factor: 20.543

Review 7.  Rheumatoid arthritis genetics: 2009 update.

Authors:  Robert M Plenge
Journal:  Curr Rheumatol Rep       Date:  2009-10       Impact factor: 4.592

8.  Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.

Authors:  Anne Barton; Steve Eyre; Xiayi Ke; Anne Hinks; John Bowes; Edward Flynn; Paul Martin; Anthony G Wilson; Ann W Morgan; Paul Emery; Sophia Steer; Lynne J Hocking; David M Reid; Pille Harrison; Paul Wordsworth; Wendy Thomson; Jane Worthington
Journal:  Hum Mol Genet       Date:  2009-04-09       Impact factor: 6.150

9.  Data for Genetic Analysis Workshop 16 Problem 1, association analysis of rheumatoid arthritis data.

Authors:  Christopher I Amos; Wei Vivien Chen; Michael F Seldin; Elaine F Remmers; Kimberly E Taylor; Lindsey A Criswell; Annette T Lee; Robert M Plenge; Daniel L Kastner; Peter K Gregersen
Journal:  BMC Proc       Date:  2009-12-15

10.  Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases.

Authors:  Hariklia Eleftherohorinou; Victoria Wright; Clive Hoggart; Anna-Liisa Hartikainen; Marjo-Riitta Jarvelin; David Balding; Lachlan Coin; Michael Levin
Journal:  PLoS One       Date:  2009-11-30       Impact factor: 3.240
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