Literature DB >> 17982455

Rheumatoid arthritis association at 6q23.

Wendy Thomson1, Anne Barton, Xiayi Ke, Steve Eyre, Anne Hinks, John Bowes, Rachelle Donn, Deborah Symmons, Samantha Hider, Ian N Bruce, Anthony G Wilson, Ioanna Marinou, Ann Morgan, Paul Emery, Angela Carter, Sophia Steer, Lynne Hocking, David M Reid, Paul Wordsworth, Pille Harrison, David Strachan, Jane Worthington.   

Abstract

The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5) - 5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3).

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Year:  2007        PMID： 17982455      PMCID： PMC2674282          DOI： 10.1038/ng.2007.32

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  13 in total

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  196 in total

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Review 8.  The genetics revolution in rheumatology: large scale genomic arrays and genetic mapping.

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