Literature DB >> 18190858

Microfluidics for drug discovery and development: from target selection to product lifecycle management.

Lifeng Kang1, Bong Geun Chung, Robert Langer, Ali Khademhosseini.   

Abstract

Microfluidic technologies' ability to miniaturize assays and increase experimental throughput have generated significant interest in the drug discovery and development domain. These characteristics make microfluidic systems a potentially valuable tool for many drug discovery and development applications. Here, we review the recent advances of microfluidic devices for drug discovery and development and highlight their applications in different stages of the process, including target selection, lead identification, preclinical tests, clinical trials, chemical synthesis, formulations studies and product management.

Mesh:

Year:  2007        PMID: 18190858      PMCID: PMC2700821          DOI: 10.1016/j.drudis.2007.10.003

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN: 1359-6446            Impact factor:   7.851


  103 in total

Review 1.  Microfabricated microneedles for gene and drug delivery.

Authors:  D V McAllister; M G Allen; M R Prausnitz
Journal:  Annu Rev Biomed Eng       Date:  2000       Impact factor: 9.590

Review 2.  Clinical proteomics: translating benchside promise into bedside reality.

Authors:  Emanuel F Petricoin; Kathryn C Zoon; Elise C Kohn; J Carl Barrett; Lance A Liotta
Journal:  Nat Rev Drug Discov       Date:  2002-09       Impact factor: 84.694

Review 3.  Structure-based strategies for drug design and discovery.

Authors:  I D Kuntz
Journal:  Science       Date:  1992-08-21       Impact factor: 47.728

4.  Generation of monodisperse particles by using microfluidics: control over size, shape, and composition.

Authors:  Shengqing Xu; Zhihong Nie; Minseok Seo; Patrick Lewis; Eugenia Kumacheva; Howard A Stone; Piotr Garstecki; Douglas B Weibel; Irina Gitlin; George M Whitesides
Journal:  Angew Chem Int Ed Engl       Date:  2005-01-21       Impact factor: 15.336

5.  Fully integrated whole blood testing by real-time absorption measurement on a centrifugal platform.

Authors:  J Steigert; M Grumann; T Brenner; L Riegger; J Harter; R Zengerle; J Ducrée
Journal:  Lab Chip       Date:  2006-06-05       Impact factor: 6.799

Review 6.  Critical review of the role of HTS in drug discovery.

Authors:  Ricardo Macarron
Journal:  Drug Discov Today       Date:  2006-04       Impact factor: 7.851

7.  Five years on...and four challenges for the pharmaceutical industry.

Authors: 
Journal:  Nat Rev Drug Discov       Date:  2007-01       Impact factor: 84.694

8.  A capillary-based microfluidic instrument suitable for immunoaffinity chromatography.

Authors:  Michael C Peoples; Terry M Phillips; H Thomas Karnes
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2006-11-13       Impact factor: 3.205

9.  Microfluidic PicoArray synthesis of oligodeoxynucleotides and simultaneous assembling of multiple DNA sequences.

Authors:  Xiaochuan Zhou; Shiying Cai; Ailing Hong; Qimin You; Peilin Yu; Nijing Sheng; Onnop Srivannavit; Seema Muranjan; Jean Marie Rouillard; Yongmei Xia; Xiaolin Zhang; Qin Xiang; Renuka Ganesh; Qi Zhu; Anna Matejko; Erdogan Gulari; Xiaolian Gao
Journal:  Nucleic Acids Res       Date:  2004-10-11       Impact factor: 16.971

10.  Miniaturized assay for solubility and residual solid screening (SORESOS) in early drug development.

Authors:  Nicole Wyttenbach; Jochem Alsenz; Olaf Grassmann
Journal:  Pharm Res       Date:  2007-03-20       Impact factor: 4.580

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  63 in total

1.  Microfluidic droplet encapsulation of highly motile single zoospores for phenotypic screening of an antioomycete chemical.

Authors:  Haifeng Yang; Xuan Qiao; Madan K Bhattacharyya; Liang Dong
Journal:  Biomicrofluidics       Date:  2011-10-13       Impact factor: 2.800

Review 2.  Microfabrication technologies for oral drug delivery.

Authors:  Shilpa Sant; Sarah L Tao; Omar Z Fisher; Qiaobing Xu; Nicholas A Peppas; Ali Khademhosseini
Journal:  Adv Drug Deliv Rev       Date:  2011-12-04       Impact factor: 15.470

3.  Designing a sensitive and quantifiable nanocolloid assay with dielectrophoretic crossover frequencies.

Authors:  Sagnik Basuray; Hsueh-Chia Chang
Journal:  Biomicrofluidics       Date:  2010-01-22       Impact factor: 2.800

Review 4.  Concise Review: Stem Cell Microenvironment on a Chip: Current Technologies for Tissue Engineering and Stem Cell Biology.

Authors:  DoYeun Park; Jaeho Lim; Joong Yull Park; Sang-Hoon Lee
Journal:  Stem Cells Transl Med       Date:  2015-10-08       Impact factor: 6.940

Review 5.  Skeletal muscle tissue engineering: methods to form skeletal myotubes and their applications.

Authors:  Serge Ostrovidov; Vahid Hosseini; Samad Ahadian; Toshinori Fujie; Selvakumar Prakash Parthiban; Murugan Ramalingam; Hojae Bae; Hirokazu Kaji; Ali Khademhosseini
Journal:  Tissue Eng Part B Rev       Date:  2014-02-24       Impact factor: 6.389

6.  Scaffold fabrication in a perfusion culture microchamber array chip by O(2) plasma bonding of poly(dimethylsiloxane) protected by a physical mask.

Authors:  Koji Hattori; Shinji Sugiura; Toshiyuki Kanamori
Journal:  Biomicrofluidics       Date:  2011-06-29       Impact factor: 2.800

7.  Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments.

Authors:  Ioannis K Zervantonakis; Chandrasekhar R Kothapalli; Seok Chung; Ryo Sudo; Roger D Kamm
Journal:  Biomicrofluidics       Date:  2011-03-30       Impact factor: 2.800

8.  Multifunctional, inexpensive, and reusable nanoparticle-printed biochip for cell manipulation and diagnosis.

Authors:  Rahim Esfandyarpour; Matthew J DiDonato; Yuxin Yang; Naside Gozde Durmus; James S Harris; Ronald W Davis
Journal:  Proc Natl Acad Sci U S A       Date:  2017-02-06       Impact factor: 11.205

9.  Processing of nanolitre liquid plugs for microfluidic cell-based assays.

Authors:  Junji Fukuda; Shintaro Takahashi; Tatsuya Osaki; Naoto Mochizuki; Hiroaki Suzuki
Journal:  Sci Technol Adv Mater       Date:  2012-10-18       Impact factor: 8.090

Review 10.  Nano/Microfluidics for diagnosis of infectious diseases in developing countries.

Authors:  Won Gu Lee; Yun-Gon Kim; Bong Geun Chung; Utkan Demirci; Ali Khademhosseini
Journal:  Adv Drug Deliv Rev       Date:  2009-11-30       Impact factor: 15.470

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