Literature DB >> 1867956

Clinical pharmacology through the looking glass: reflections on the racemate vs enantiomer debate.

M S Lennard1.   

Abstract

Mesh:

Year:  1991        PMID: 1867956      PMCID: PMC1368570          DOI: 10.1111/j.1365-2125.1991.tb05583.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN: 0306-5251            Impact factor:   4.335


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  21 in total

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4.  Pharmacodynamic and pharmacokinetic differences between drug enantiomers in humans: an overview.

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Review 5.  Importance of drug enantiomers in clinical pharmacology.

Authors:  K Williams; E Lee
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Review 6.  Problems in therapeutic drug monitoring: the dilemma of enantiomeric drugs in man.

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7.  Ocular beta-blockers and systemic effects.

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8.  Bronchial beta-adrenoceptor blockade following eyedrops of timolol and its isomer L-714,465 in normal subjects.

Authors:  R Richards; A E Tattersfield
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9.  Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology.

Authors:  E J Ariëns
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

10.  Stereospecificity of the enzymatic biotransformation of the enantiomers of prilocaine (Citanest).

Authors:  B Akerman; S Ross
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1970
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3.  Thalidomide-induced neuropathy and genetic differences in drug metabolism.

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5.  Effects of dilevalol (R,R-labetalol) compared with nifedipine on heart rate, blood pressure and muscle blood flow at rest and on exercise in hypertensive patients.

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Review 6.  Stereoisomers and drug toxicity. The value of single stereoisomer therapy.

Authors:  A K Scott
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7.  Equipotent inhibition by R(-)-, S(+)- and racemic ibuprofen of human polymorphonuclear cell function in vitro.

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