Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Neurofibrillary tau pathology modulated by genetic variation of alpha-synuclein.

Literature DB >> 18661559

Neurofibrillary tau pathology modulated by genetic variation of alpha-synuclein.

Terhi Peuralinna¹, Minna Oinas, Tuomo Polvikoski, Anders Paetau, Raimo Sulkava, Leena Niinistö, Hannu Kalimo, Dena Hernandez, John Hardy, Andrew Singleton, Pentti J Tienari, Liisa Myllykangas.

Abstract

We analyzed whether genetic variation of alpha-synuclein modulates the extent of neuropathological changes in a population-based autopsied sample of 272 elderly Finns. None of the 11 markers was associated with the extent of neocortical beta-amyloid pathology. The intron 4 marker rs2572324 was associated with the extent of neurofibrillary pathology (p = 0.0006, permuted p = 0.004; Braak stages IV-VI vs 0-II). The same variant also showed a trend for association with neocortical Lewy-related pathology. These results suggest for the first time that variation of alpha-synuclein modulates neurofibrillary tau pathology and support the recent observations of an interaction of alpha-synuclein and tau in neurodegeneration.

Entities: Chemical

Mesh：

Substances：

Year: 2008 PMID： 18661559 PMCID： PMC8957216 DOI： 10.1002/ana.21446

Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422

21 in total

1. Staging of brain pathology related to sporadic Parkinson's disease.

Authors: Heiko Braak; Kelly Del Tredici; Udo Rüb; Rob A I de Vos; Ernst N H Jansen Steur; Eva Braak
Journal: Neurobiol Aging Date: 2003 Mar-Apr Impact factor: 4.673

2. Interaction of alpha-synuclein and tau genotypes in Parkinson's disease.

Authors: Catherine E Mamah; Timothy G Lesnick; Sarah J Lincoln; Kari J Strain; Mariza de Andrade; James H Bower; J Eric Ahlskog; Walter A Rocca; Matthew J Farrer; Demetrius M Maraganore
Journal: Ann Neurol Date: 2005-03 Impact factor: 10.422

3. Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease.

Authors: E R Martin; W K Scott; M A Nance; R L Watts; J P Hubble; W C Koller; K Lyons; R Pahwa; M B Stern; A Colcher; B C Hiner; J Jankovic; W G Ondo; F H Allen; C G Goetz; G W Small; D Masterman; F Mastaglia; N G Laing; J M Stajich; R C Ribble; M W Booze; A Rogala; M A Hauser; F Zhang; R A Gibson; L T Middleton; A D Roses; J L Haines; B L Scott; M A Pericak-Vance; J M Vance
Journal: JAMA Date: 2001-11-14 Impact factor: 56.272

4. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.

Authors: M H Polymeropoulos; C Lavedan; E Leroy; S E Ide; A Dehejia; A Dutra; B Pike; H Root; J Rubenstein; R Boyer; E S Stenroos; S Chandrasekharappa; A Athanassiadou; T Papapetropoulos; W G Johnson; A M Lazzarini; R C Duvoisin; G Di Iorio; L I Golbe; R L Nussbaum
Journal: Science Date: 1997-06-27 Impact factor: 47.728

5. Linkage disequilibrium and association analysis of alpha-synuclein and alcohol and drug dependence in two American Indian populations.

Authors: Jordi Clarimon; Rebecca R Gray; Lindsey N Williams; Mary-Anne Enoch; Robert W Robin; Bernard Albaugh; Andrew Singleton; David Goldman; Connie J Mulligan
Journal: Alcohol Clin Exp Res Date: 2007-04 Impact factor: 3.455

6. Multiple regions of alpha-synuclein are associated with Parkinson's disease.

Authors: Jakob C Mueller; Julia Fuchs; Anne Hofer; Alexander Zimprich; Peter Lichtner; Thomas Illig; Daniela Berg; Ullrich Wüllner; Thomas Meitinger; Thomas Gasser
Journal: Ann Neurol Date: 2005-04 Impact factor: 10.422

7. Prevalence of Alzheimer's disease in very elderly people: a prospective neuropathological study.

Authors: T Polvikoski; R Sulkava; L Myllykangas; I L Notkola; L Niinistö; A Verkkoniemi; K Kainulainen; K Kontula; J Pérez-Tur; J Hardy; M Haltia
Journal: Neurology Date: 2001-06-26 Impact factor: 9.910

8. alpha-Synuclein gene haplotypes are associated with Parkinson's disease.

Authors: M Farrer; D M Maraganore; P Lockhart; A Singleton; T G Lesnick; M de Andrade; A West; R de Silva; J Hardy; D Hernandez
Journal: Hum Mol Genet Date: 2001-08-15 Impact factor: 6.150

Review 9. Interface between tauopathies and synucleinopathies: a tale of two proteins.

Authors: Wendy R Galpern; Anthony E Lang
Journal: Ann Neurol Date: 2006-03 Impact factor: 10.422

Review 10. Neuropathological stageing of Alzheimer-related changes.

Authors: H Braak; E Braak
Journal: Acta Neuropathol Date: 1991 Impact factor: 17.088

11 in total

1. An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology.

Authors: Christian Wider; Owen A Ross; Kenya Nishioka; Michael G Heckman; Carles Vilariño-Güell; Barbara Jasinska-Myga; Nilufer Erketin-Taner; Rosa Rademakers; Neill R Graff-Radford; Deborah C Mash; Spiridon Papapetropoulos; Ranjan Duara; Hirotake Uchikado; Zbigniew K Wszolek; Matthew J Farrer; Dennis W Dickson
Journal: J Neurol Neurosurg Psychiatry Date: 2012-01-30 Impact factor: 10.154

2. Parkinson's disease susceptibility variants and severity of Lewy body pathology.

Authors: Michael G Heckman; Koji Kasanuki; Nancy N Diehl; Shunsuke Koga; Alexandra Soto; Melissa E Murray; Dennis W Dickson; Owen A Ross
Journal: Parkinsonism Relat Disord Date: 2017-09-11 Impact factor: 4.891

3. LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease.

Authors: Carles Vilariño-Güell; Christian Wider; Owen A Ross; Barbara Jasinska-Myga; Jennifer Kachergus; Stephanie A Cobb; Alexandra I Soto-Ortolaza; Bahareh Behrouz; Michael G Heckman; Nancy N Diehl; Claudia M Testa; Zbigniew K Wszolek; Ryan J Uitti; Joseph Jankovic; Elan D Louis; Lorraine N Clark; Alex Rajput; Matthew J Farrer
Journal: Neurogenetics Date: 2010-04-06 Impact factor: 2.660

4. APOE and AβPP gene variation in cortical and cerebrovascular amyloid-β pathology and Alzheimer's disease: a population-based analysis.

Authors: Terhi Peuralinna; Maarit Tanskanen; Mira Mäkelä; Tuomo Polvikoski; Anders Paetau; Hannu Kalimo; Raimo Sulkava; John Hardy; Shiao-Lin Lai; Sampath Arepalli; Dena Hernandez; Bryan J Traynor; Andrew Singleton; Pentti J Tienari; Liisa Myllykangas
Journal: J Alzheimers Dis Date: 2011 Impact factor: 4.472

5. Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.

Authors: Dalia Kasperaviciūte; Claudia B Catarino; Erin L Heinzen; Chantal Depondt; Gianpiero L Cavalleri; Luis O Caboclo; Sarah K Tate; Jenny Jamnadas-Khoda; Krishna Chinthapalli; Lisa M S Clayton; Kevin V Shianna; Rodney A Radtke; Mohamad A Mikati; William B Gallentine; Aatif M Husain; Saud Alhusaini; David Leppert; Lefkos T Middleton; Rachel A Gibson; Michael R Johnson; Paul M Matthews; David Hosford; Kjell Heuser; Leslie Amos; Marcos Ortega; Dominik Zumsteg; Heinz-Gregor Wieser; Bernhard J Steinhoff; Günter Krämer; Jörg Hansen; Thomas Dorn; Anne-Mari Kantanen; Leif Gjerstad; Terhi Peuralinna; Dena G Hernandez; Kai J Eriksson; Reetta K Kälviäinen; Colin P Doherty; Nicholas W Wood; Massimo Pandolfo; John S Duncan; Josemir W Sander; Norman Delanty; David B Goldstein; Sanjay M Sisodiya
Journal: Brain Date: 2010-06-03 Impact factor: 13.501