Literature DB >> 15732111

Interaction of alpha-synuclein and tau genotypes in Parkinson's disease.

Catherine E Mamah1, Timothy G Lesnick, Sarah J Lincoln, Kari J Strain, Mariza de Andrade, James H Bower, J Eric Ahlskog, Walter A Rocca, Matthew J Farrer, Demetrius M Maraganore.   

Abstract

To determine whether the microtubule-associated protein tau (MAPT) and alpha-synuclein (SNCA) genes interact to confer Parkinson's disease (PD) susceptibility, we conducted a study of 557 case-control pairs. There was an increased risk of PD for persons with either SNCA 261/261 or MAPT H1/H1 genotypes as compared with persons with neither (odds ratio, 1.96; 95% confidence interval, 1.34-2.86; p = 0.0003). However, the combined effect of the two genotypes was the same as for either of the genotypes alone (separate and equal). These findings are consistent with in vitro experiments that revealed tau-mediated fibrillization of alpha-synuclein protein at low concentrations (dose threshold effect).

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Year:  2005        PMID： 15732111     DOI： 10.1002/ana.20387

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  18 in total

1.  Do interactions between SNCA, MAPT, and LRRK2 genes contribute to Parkinson's disease susceptibility?

Authors:  Joanna M Biernacka; Sebastian M Armasu; Julie M Cunningham; J Eric Ahlskog; Sun Ju Chung; Demetrius M Maraganore
Journal:  Parkinsonism Relat Disord       Date:  2011-08-03       Impact factor: 4.891

2.  Common variants in PARK loci and related genes and Parkinson's disease.

Authors:  Sun Ju Chung; Sebastian M Armasu; Joanna M Biernacka; Timothy G Lesnick; David N Rider; Sarah J Lincoln; Alexandra I Ortolaza; Matthew J Farrer; Julie M Cunningham; Walter A Rocca; Demetrius M Maraganore
Journal:  Mov Disord       Date:  2010-12-13       Impact factor: 10.338

3.  Abnormal neurites containing C-terminally truncated alpha-synuclein are present in Alzheimer's disease without conventional Lewy body pathology.

Authors:  Karen A Lewis; Yang Su; Olina Jou; Caroline Ritchie; Chan Foong; Linda S Hynan; Charles L White; Philip J Thomas; Kimmo J Hatanpaa
Journal:  Am J Pathol       Date:  2010-11-05       Impact factor: 4.307

4.  High-resolution whole-genome association study of Parkinson disease.

Authors:  Demetrius M Maraganore; Mariza de Andrade; Timothy G Lesnick; Kari J Strain; Matthew J Farrer; Walter A Rocca; P V Krishna Pant; Kelly A Frazer; David R Cox; Dennis G Ballinger
Journal:  Am J Hum Genet       Date:  2005-09-09       Impact factor: 11.025

Review 5.  Genetic variability in SNCA and Parkinson's disease.

Authors:  Lasse Pihlstrøm; Mathias Toft
Journal:  Neurogenetics       Date:  2011-07-29       Impact factor: 2.660

Review 6.  Interactions Between α-Synuclein and Tau Protein: Implications to Neurodegenerative Disorders.

Authors:  Xuling Li; Simon James; Peng Lei
Journal:  J Mol Neurosci       Date:  2016-09-15       Impact factor: 3.444

7.  Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.

Authors:  Todd L Edwards; William K Scott; Cherylyn Almonte; Amber Burt; Eric H Powell; Gary W Beecham; Liyong Wang; Stephan Züchner; Ioanna Konidari; Gaofeng Wang; Carlos Singer; Fatta Nahab; Burton Scott; Jeffrey M Stajich; Margaret Pericak-Vance; Jonathan Haines; Jeffery M Vance; Eden R Martin
Journal:  Ann Hum Genet       Date:  2010-01-08       Impact factor: 1.670

8.  Physiological transgene regulation and functional complementation of a neurological disease gene deficiency in neurons.

Authors:  Pier Paolo Peruzzi; Sean E Lawler; Steve L Senior; Nina Dmitrieva; Pauline A H Edser; Davide Gianni; E Antonio Chiocca; Richard Wade-Martins
Journal:  Mol Ther       Date:  2009-04-07       Impact factor: 11.454

Review 9.  Recent advances in our understanding of neurodegeneration.

Authors:  Kurt A Jellinger
Journal:  J Neural Transm (Vienna)       Date:  2009-06-05       Impact factor: 3.575

10.  Protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants.

Authors:  Michael G Heckman; Alexis Elbaz; Alexandra I Soto-Ortolaza; Daniel J Serie; Jan O Aasly; Grazia Annesi; Georg Auburger; Justin A Bacon; Magdalena Boczarska-Jedynak; Maria Bozi; Laura Brighina; Marie-Christine Chartier-Harlin; Efthimios Dardiotis; Alain Destée; Carlo Ferrarese; Alessandro Ferraris; Brian Fiske; Suzana Gispert; Georgios M Hadjigeorgiou; Nobutaka Hattori; John P A Ioannidis; Barbara Jasinska-Myga; Beom S Jeon; Yun Joong Kim; Christine Klein; Rejko Kruger; Elli Kyratzi; Chin-Hsien Lin; Katja Lohmann; Marie-Anne Loriot; Timothy Lynch; George D Mellick; Eugénie Mutez; Grzegorz Opala; Sung Sup Park; Simona Petrucci; Aldo Quattrone; Manu Sharma; Peter A Silburn; Young Ho Sohn; Leonidas Stefanis; Vera Tadic; Hiroyuki Tomiyama; Ryan J Uitti; Enza Maria Valente; Demetrios K Vassilatis; Carles Vilariño-Güell; Linda R White; Karin Wirdefeldt; Zbigniew K Wszolek; Ruey-Meei Wu; Georgia Xiromerisiou; Demetrius M Maraganore; Matthew J Farrer; Owen A Ross
Journal:  Neurobiol Aging       Date:  2013-08-17       Impact factor: 4.673
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