| Literature DB >> 11532993 |
M Farrer1, D M Maraganore, P Lockhart, A Singleton, T G Lesnick, M de Andrade, A West, R de Silva, J Hardy, D Hernandez.
Abstract
We report haplotype analysis of the alpha-synuclein gene in Parkinson's disease (PD), extending earlier reports of an association with a polymorphism within the gene promoter. This analysis showed significant differences in haplotypes between PD cases and controls. Our analyses demonstrate that genetic variability in the alpha-synuclein gene is a risk factor for the development of PD. These genetic findings are analogous to the tau haplotype over-represented in progressive supranuclear palsy and further extend the similarity in the etiologies and pathogeneses of the synucleinopathies and tauopathies.Entities:
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Year: 2001 PMID： 11532993 DOI： 10.1093/hmg/10.17.1847
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150