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Literature DB >> 18648611

Cancer control related to stimulation of immunity by low-dose radiation.

Abstract

Previous studies showed that low dose radiation (LDR) could stimulate the immune system in both animal and human populations. This paper reviews the present status of relevant research as support to the use of LDR in clinical practice for cancer prevention and treatment. It has been demonstrated that radiation-induced changes in immune activity follows an inverse J-shaped curve, i.e., low dose stimulation and high dose suppression. The stimulation of immunity by LDR concerns most anticancer parameters, including antibody formation, natural killer activity, secretion of interferon and other cytokines as well as other cellular changes. Animal studies have revealed that LDR retards tumor growth, decreases cancer metastasis, and inhibits carcinogenesis induced by high dose radiation. These effects of LDR on cancer control were found to be related to its stimulation on immunity. The experimental data may well explain the efficacy of the clinical trial of LDR in the treatment of cancer.

Entities: Disease Species

Year: 2006 PMID： 18648611 PMCID： PMC2477702 DOI： 10.2203/dose-response.06-108.Liu

Source DB: PubMed Journal: Dose Response ISSN： 1559-3258 Impact factor: 2.658

12 in total

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9. Nonlinear dose-response relationship in the immune system following exposure to ionizing radiation: mechanisms and implications.

Authors: Shu-Zheng Liu
Journal: Nonlinearity Biol Toxicol Med Date: 2003-01

Cancer control related to stimulation of immunity by low-dose radiation.

Review 1. Radiation hormesis: data and interpretations.

Review 2. On radiation hormesis expressed in the immune system.

3. Cultured mouse SR-1 cells exposed to low dose of gamma-rays become less susceptible to the induction of mutagenesis by radiation as well as bleomycin.

Review 4. Radioadaptation for gene mutation and the possible molecular mechanisms of the adaptive response.

Review 5. Cellular mechanisms of protection and repair induced by radiation exposure and their consequences for cell system responses.

6. Increased SOD activities and decreased lipid peroxide levels induced by low dose X irradiation in rat organs.

7. Involvement of the Ca(2+)-protein kinase C and adenyilate cyclace signal pathways in the activation of thymocytes in response to whole-body irradiation with low dose X-rays.

8. Effect of low dose radiation on intracellular calcium and protein kinase C in lymphocytes.

9. Nonlinear dose-response relationship in the immune system following exposure to ionizing radiation: mechanisms and implications.

10. Role of CD28/B7 costimulation and IL-12/IL-10 interaction in the radiation-induced immune changes.

1. The healthy worker effect and nuclear industry workers.

2. Nuclear energy and health: and the benefits of low-dose radiation hormesis.

3. The linear no-threshold relationship is inconsistent with radiation biologic and experimental data.

4. Enhancement of monoclonal antibody production in CHO cells by exposure to He-Ne laser radiation.

5. The effects of Fhit on tumorigenesis after multi-exposure to low-dose radiation.

6. Evidence for radiation hormesis after in vitro exposure of human lymphocytes to low doses of ionizing radiation.

7. Editorial: is airport body-scan radiation a health risk?

8. The new radiobiology: returning to our roots.

9. First generation stochastic gene episilencing (step1) model and applications to in vitro carcinogen exposure.

10. Low dose radiation adaptive protection to control neurodegenerative diseases.