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Literature DB >> 19546369

A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.

Abstract

Indolmycin, a potential antibacterial drug, competitively inhibits bacterial tryptophanyl-tRNA synthetases. An effort to identify indolmycin resistance genes led to the discovery of a gene encoding an indolmycin-resistant isoform of tryptophanyl-tRNA synthetase. Overexpression of this gene in an indolmycin-sensitive strain increased the indolmycin MIC 60-fold. Its transcription and distribution in various bacterial genera were assessed. The level of resistance conferred by this gene was compared to that of a known indolmycin resistance gene and to those of genes with resistance-conferring point mutations.

Entities: Chemical Gene

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Year: 2009 PMID： 19546369 PMCID： PMC2737876 DOI： 10.1128/AAC.00723-09

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

36 in total

Review 1. Inhibitors of aminoacyl-tRNA synthetases as novel anti-infectives.

Authors: J Tao; P Schimmel
Journal: Expert Opin Investig Drugs Date: 2000-08 Impact factor: 6.206

2. The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.

Authors: Murray J Brown; Paul S Carter; Ashley S Fenwick; Andrew P Fosberry; Dieter W Hamprecht; Martin J Hibbs; Richard L Jarvest; Lucy Mensah; Peter H Milner; Peter J O'Hanlon; Andrew J Pope; Christine M Richardson; Andrew West; David R Witty
Journal: Bioorg Med Chem Lett Date: 2002-11-04 Impact factor: 2.823

Review 3. Aminoacyl-tRNA synthetases and their inhibitors as a novel family of antibiotics.

Authors: S Kim; S W Lee; E-C Choi; S Y Choi
Journal: Appl Microbiol Biotechnol Date: 2003-03-01 Impact factor: 4.813

4. Characterization of an inducible, antibiotic-resistant aminoacyl-tRNA synthetase gene in Streptomyces coelicolor.

Authors: James J Vecchione; Jason K Sello
Journal: J Bacteriol Date: 2008-07-11 Impact factor: 3.490

5. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).

Authors: S D Bentley; K F Chater; A-M Cerdeño-Tárraga; G L Challis; N R Thomson; K D James; D E Harris; M A Quail; H Kieser; D Harper; A Bateman; S Brown; G Chandra; C W Chen; M Collins; A Cronin; A Fraser; A Goble; J Hidalgo; T Hornsby; S Howarth; C-H Huang; T Kieser; L Larke; L Murphy; K Oliver; S O'Neil; E Rabbinowitsch; M-A Rajandream; K Rutherford; S Rutter; K Seeger; D Saunders; S Sharp; R Squares; S Squares; K Taylor; T Warren; A Wietzorrek; J Woodward; B G Barrell; J Parkhill; D A Hopwood
Journal: Nature Date: 2002-05-09 Impact factor: 49.962

6. Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.

Authors: S Omura; H Ikeda; J Ishikawa; A Hanamoto; C Takahashi; M Shinose; Y Takahashi; H Horikawa; H Nakazawa; T Osonoe; H Kikuchi; T Shiba; Y Sakaki; M Hattori
Journal: Proc Natl Acad Sci U S A Date: 2001-09-25 Impact factor: 11.205

7. Development of a stereoselective practical synthetic route to indolmycin, a candidate anti-H. pylori agent.

Authors: A Hasuoka; Y Nakayama; M Adachi; H Kamiguchi; K Kamiyama
Journal: Chem Pharm Bull (Tokyo) Date: 2001-12 Impact factor: 1.645

8. Indolmycin resistance of Streptomyces coelicolor A3(2) by induced expression of one of its two tryptophanyl-tRNA synthetases.

Authors: Makoto Kitabatake; Kamilah Ali; Arnold Demain; Kensaku Sakamoto; Shigeyuki Yokoyama; Dieter Söll
Journal: J Biol Chem Date: 2002-04-22 Impact factor: 5.157

9. Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.

Authors: Haruo Ikeda; Jun Ishikawa; Akiharu Hanamoto; Mayumi Shinose; Hisashi Kikuchi; Tadayoshi Shiba; Yoshiyuki Sakaki; Masahira Hattori; Satoshi Omura
Journal: Nat Biotechnol Date: 2003-04-14 Impact factor: 54.908

10. Variable sensitivity to bacterial methionyl-tRNA synthetase inhibitors reveals subpopulations of Streptococcus pneumoniae with two distinct methionyl-tRNA synthetase genes.

Authors: Daniel R Gentry; Karen A Ingraham; Michael J Stanhope; Stephen Rittenhouse; Richard L Jarvest; Peter J O'Hanlon; James R Brown; David J Holmes
Journal: Antimicrob Agents Chemother Date: 2003-06 Impact factor: 5.191

11 in total

1. Regulation of an auxiliary, antibiotic-resistant tryptophanyl-tRNA synthetase gene via ribosome-mediated transcriptional attenuation.

Authors: James J Vecchione; Jason K Sello
Journal: J Bacteriol Date: 2010-05-07 Impact factor: 3.490

A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.

Review 1. Inhibitors of aminoacyl-tRNA synthetases as novel anti-infectives.

2. The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.

Review 3. Aminoacyl-tRNA synthetases and their inhibitors as a novel family of antibiotics.

4. Characterization of an inducible, antibiotic-resistant aminoacyl-tRNA synthetase gene in Streptomyces coelicolor.

5. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).

6. Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.

7. Development of a stereoselective practical synthetic route to indolmycin, a candidate anti-H. pylori agent.

8. Indolmycin resistance of Streptomyces coelicolor A3(2) by induced expression of one of its two tryptophanyl-tRNA synthetases.

9. Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.

10. Variable sensitivity to bacterial methionyl-tRNA synthetase inhibitors reveals subpopulations of Streptococcus pneumoniae with two distinct methionyl-tRNA synthetase genes.

1. Regulation of an auxiliary, antibiotic-resistant tryptophanyl-tRNA synthetase gene via ribosome-mediated transcriptional attenuation.

Review 2. Biased gene transfer in microbial evolution.

Review 3. Comparison of Antibiotic Resistance Mechanisms in Antibiotic-Producing and Pathogenic Bacteria.

4. In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly.

Review 5. Exploring alternative treatments for Helicobacter pylori infection.

6. Antibacterial activity of and resistance to small molecule inhibitors of the ClpP peptidase.

7. Selective Inhibition of Bacterial Tryptophanyl-tRNA Synthetases by Indolmycin Is Mechanism-based.

Review 8. Crossroads of Antibiotic Resistance and Biosynthesis.

9. Ancient origin of the divergent forms of leucyl-tRNA synthetases in the Halobacteriales.

10. An Integrated Metabolomic and Genomic Mining Workflow To Uncover the Biosynthetic Potential of Bacteria.