Literature DB >> 18616341

A concise total synthesis of largazole, solution structure, and some preliminary structure activity relationships.

Christopher G Nasveschuk1, Dana Ungermannova, Xuedong Liu, Andrew J Phillips.   

Abstract

A total synthesis of largazole that proceeds in 8 steps from commercial materials is reported, along with some structure-activity relationships. A combination of NMR studies and molecular modeling have also provided a preliminary picture of the conformation of largazole.

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Year:  2008        PMID： 18616341      PMCID： PMC2664405          DOI： 10.1021/ol8013478

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  10 in total

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  10 in total
  25 in total

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