Literature DB >> 16620095

Total synthesis of (-)-dictyostatin.

Gregory W O'Neil1, Andrew J Phillips.   

Abstract

A convergent total synthesis of dictyostatin is described. Key features of the synthesis include the use of titanium-mediated cyclizations of (silyloxy)enynes for the synthesis of stereotriads, a subunit coupling by metathesis, and macrocyclization by intramolecular Horner-Wadsworth-Emmons olefination.

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Year:  2006        PMID： 16620095     DOI： 10.1021/ja0609708

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  16 in total

1.  Synthesis of Linear (Z)-α,β-Unsaturated Esters by Catalytic Cross-Metathesis. The Influence of Acetonitrile.

Authors:  Elsie C Yu; Brett M Johnson; Erik M Townsend; Richard R Schrock; Amir H Hoveyda
Journal:  Angew Chem Int Ed Engl       Date:  2016-10-10       Impact factor: 15.336

Review 2.  Conformation-activity relationships of polyketide natural products.

Authors:  Erik M Larsen; Matthew R Wilson; Richard E Taylor
Journal:  Nat Prod Rep       Date:  2015-08       Impact factor: 13.423

3.  Vinylogous aldol products from chiral crotylsilanes obtained by enantioselective Rh(II) and Cu(I) carbenoid Si-H insertion.

Authors:  Jie Wu; Yu Chen; James S Panek
Journal:  Org Lett       Date:  2010-05-07       Impact factor: 6.005

4.  Selective synthesis of (2Z,4E)-dienyl esters by ene-diene cross metathesis.

Authors:  Gustavo Moura-Letts; Dennis P Curran
Journal:  Org Lett       Date:  2007-01-04       Impact factor: 6.005

Review 5.  Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.

Authors:  Carlo Ballatore; Kurt R Brunden; Donna M Huryn; John Q Trojanowski; Virginia M-Y Lee; Amos B Smith
Journal:  J Med Chem       Date:  2012-09-28       Impact factor: 7.446

6.  Streamlined syntheses of (-)-dictyostatin, 16-desmethyl-25,26-dihydrodictyostatin, and 6-epi-16-desmethyl-25,26-dihydrodictyostatin.

Authors:  Wei Zhu; María Jiménez; Won-Hyuk Jung; Daniel P Camarco; Raghavan Balachandran; Andreas Vogt; Billy W Day; Dennis P Curran
Journal:  J Am Chem Soc       Date:  2010-07-07       Impact factor: 15.419

7.  Phosphate-tether-mediated ring-closing metathesis for the preparation of complex 1,3-anti-diol-containing subunits.

Authors:  Rambabu Chegondi; Soma Maitra; Jana L Markley; Paul R Hanson
Journal:  Chemistry       Date:  2013-05-24       Impact factor: 5.236

8.  Alkylidenesilacyclopropanes derived from allenes: applications to the selective synthesis of triols and homoallylic alcohols.

Authors:  Kay M Buchner; Timothy B Clark; Janice M N Loy; Thong X Nguyen; K A Woerpel
Journal:  Org Lett       Date:  2009-05-21       Impact factor: 6.005

9.  A concise total synthesis of largazole, solution structure, and some preliminary structure activity relationships.

Authors:  Christopher G Nasveschuk; Dana Ungermannova; Xuedong Liu; Andrew J Phillips
Journal:  Org Lett       Date:  2008-07-11       Impact factor: 6.005

10.  Stereoselective synthesis of dienyl-carboxylate building blocks: formal synthesis of inthomycin C.

Authors:  Caroline Souris; Frédéric Frébault; Ashay Patel; Davide Audisio; K N Houk; Nuno Maulide
Journal:  Org Lett       Date:  2013-06-13       Impact factor: 6.005
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