Literature DB >> 18594563

ATR: an essential regulator of genome integrity.

Karlene A Cimprich1, David Cortez.   

Abstract

Genome maintenance is a constant concern for cells, and a coordinated response to DNA damage is required to maintain cellular viability and prevent disease. The ataxia-telangiectasia mutated (ATM) and ATM and RAD3-related (ATR) protein kinases act as master regulators of the DNA-damage response by signalling to control cell-cycle transitions, DNA replication, DNA repair and apoptosis. Recent studies have provided new insights into the mechanisms that control ATR activation, have helped to explain the overlapping but non-redundant activities of ATR and ATM in DNA-damage signalling, and have clarified the crucial functions of ATR in maintaining genome integrity.

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Year:  2008        PMID： 18594563      PMCID： PMC2663384          DOI： 10.1038/nrm2450

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  189 in total

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Authors:  Y Xiao; D T Weaver
Journal:  Nucleic Acids Res       Date:  1997-08-01       Impact factor: 16.971

2.  Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II.

Authors:  A Dvir; S R Peterson; M W Knuth; H Lu; W S Dynan
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-15       Impact factor: 11.205

3.  ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation.

Authors:  Heather L Ball; Jeremy S Myers; David Cortez
Journal:  Mol Biol Cell       Date:  2005-03-02       Impact factor: 4.138

4.  Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

Authors:  Tony S Byun; Marcin Pacek; Muh-ching Yee; Johannes C Walter; Karlene A Cimprich
Journal:  Genes Dev       Date:  2005-04-15       Impact factor: 11.361

Review 5.  Instability and decay of the primary structure of DNA.

Authors:  T Lindahl
Journal:  Nature       Date:  1993-04-22       Impact factor: 49.962

6.  Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.

Authors:  D Cortez; Y Wang; J Qin; S J Elledge
Journal:  Science       Date:  1999-11-05       Impact factor: 47.728

7.  The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast.

Authors:  G S Brush; D M Morrow; P Hieter; T J Kelly
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-24       Impact factor: 11.205

8.  Rheb binds and regulates the mTOR kinase.

Authors:  Xiaomeng Long; Yenshou Lin; Sara Ortiz-Vega; Kazuyoshi Yonezawa; Joseph Avruch
Journal:  Curr Biol       Date:  2005-04-26       Impact factor: 10.834

9.  The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen.

Authors:  T M Gottlieb; S P Jackson
Journal:  Cell       Date:  1993-01-15       Impact factor: 41.582

10.  Breast and other cancers in families with ataxia-telangiectasia.

Authors:  M Swift; P J Reitnauer; D Morrell; C L Chase
Journal:  N Engl J Med       Date:  1987-05-21       Impact factor: 91.245
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  877 in total

Review 1.  A tough row to hoe: when replication forks encounter DNA damage.

Authors:  Darshil R Patel; Robert S Weiss
Journal:  Biochem Soc Trans       Date:  2018-12-04       Impact factor: 5.407

2.  The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair.

Authors:  Thuy-Ai Nguyen; Scott D Slattery; Sung-Hwan Moon; Yolanda F Darlington; Xiongbin Lu; Lawrence A Donehower
Journal:  DNA Repair (Amst)       Date:  2010-05-06

3.  Chromosome rearrangements and aneuploidy in yeast strains lacking both Tel1p and Mec1p reflect deficiencies in two different mechanisms.

Authors:  Jennifer L McCulley; Thomas D Petes
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-07       Impact factor: 11.205

4.  Baculoviruses modulate a proapoptotic DNA damage response to promote virus multiplication.

Authors:  Jonathan K Mitchell; Paul D Friesen
Journal:  J Virol       Date:  2012-10-03       Impact factor: 5.103

Review 5.  Non-homologous end joining: emerging themes and unanswered questions.

Authors:  Sarvan Kumar Radhakrishnan; Nicholas Jette; Susan P Lees-Miller
Journal:  DNA Repair (Amst)       Date:  2014-02-26

6.  ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1.

Authors:  Benjamin A Hilton; Zhengke Li; Phillip R Musich; Hui Wang; Brian M Cartwright; Moises Serrano; Xiao Zhen Zhou; Kun Ping Lu; Yue Zou
Journal:  Mol Cell       Date:  2015-09-18       Impact factor: 17.970

Review 7.  Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.

Authors:  H Christian Reinhardt; Michael B Yaffe
Journal:  Curr Opin Cell Biol       Date:  2009-02-21       Impact factor: 8.382

Review 8.  Cell cycle, CDKs and cancer: a changing paradigm.

Authors:  Marcos Malumbres; Mariano Barbacid
Journal:  Nat Rev Cancer       Date:  2009-03       Impact factor: 60.716

9.  Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress.

Authors:  Irina Bruck; Daniel L Kaplan
Journal:  J Biol Chem       Date:  2013-02-04       Impact factor: 5.157

10.  The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations.

Authors:  Liang Chen; Jia-Yu Chen; Yi-Jou Huang; Ying Gu; Jinsong Qiu; Hao Qian; Changwei Shao; Xuan Zhang; Jing Hu; Hairi Li; Shunmin He; Yu Zhou; Omar Abdel-Wahab; Dong-Er Zhang; Xiang-Dong Fu
Journal:  Mol Cell       Date:  2018-01-27       Impact factor: 17.970
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