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Literature DB >> 24582502

Non-homologous end joining: emerging themes and unanswered questions.

Sarvan Kumar Radhakrishnan¹, Nicholas Jette¹, Susan P Lees-Miller².

Abstract

Non-homologous end joining (NHEJ) is the major pathway for the repair of ionizing radiation induced DNA double strand breaks in human cells. Here, we discuss current insights into the mechanism of NHEJ and the interplay between NHEJ and other pathways for repair of IR-induced DNA damage.

Entities: CellLine Chemical Disease Gene Species

Keywords: DNA double strand break repair; Ionizing radiation; Non-homologous end joining

Mesh：

Substances：

Year: 2014 PMID： 24582502 PMCID： PMC4084493 DOI： 10.1016/j.dnarep.2014.01.009

Source DB: PubMed Journal: DNA Repair (Amst) ISSN： 1568-7856

129 in total

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Journal: Clin Immunol Date: 2013-08-27 Impact factor: 3.969

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Journal: Nature Date: 2008-01-03 Impact factor: 49.962

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Journal: Cell Date: 1993-01-15 Impact factor: 41.582

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Journal: EMBO J Date: 2012-11-23 Impact factor: 11.598

8. A human XRCC4-XLF complex bridges DNA.

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Journal: Nucleic Acids Res Date: 2012-01-27 Impact factor: 16.971

Review 9. Induction and repair of clustered DNA lesions: what do we know so far?

Authors: Alexandros G Georgakilas; Peter O'Neill; Robert D Stewart
Journal: Radiat Res Date: 2013-05-17 Impact factor: 2.841

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Authors: Jessica Cottarel; Philippe Frit; Oriane Bombarde; Bernard Salles; Aurélie Négrel; Stéphanie Bernard; Penny A Jeggo; Michael R Lieber; Mauro Modesti; Patrick Calsou
Journal: J Cell Biol Date: 2013-01-21 Impact factor: 10.539

57 in total

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Review 2. DNA Repair in Drosophila: Mutagens, Models, and Missing Genes.

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Journal: Genetics Date: 2017-02 Impact factor: 4.562

3. Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer.

Authors: Susan P Lees-Miller; Tara L Beattie; John A Tainer
Journal: Nat Struct Mol Biol Date: 2016-06-07 Impact factor: 15.369

4. The Exonuclease Activity of Herpes Simplex Virus 1 UL12 Is Required for Production of Viral DNA That Can Be Packaged To Produce Infectious Virus.

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Journal: J Virol Date: 2017-11-14 Impact factor: 5.103

5. Characterization of DNA binding and pairing activities associated with the native SFPQ·NONO DNA repair protein complex.

Authors: Durga Udayakumar; William S Dynan
Journal: Biochem Biophys Res Commun Date: 2015-05-18 Impact factor: 3.575

Review 6. What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses.

Authors: Chris A Brosey; Zamal Ahmed; Susan P Lees-Miller; John A Tainer
Journal: Methods Enzymol Date: 2017-05-29 Impact factor: 1.600

7. Characterization of Cardiac Glycoside Natural Products as Potent Inhibitors of DNA Double-Strand Break Repair by a Whole-Cell Double Immunofluorescence Assay.

Authors: Yulia V Surovtseva; Vikram Jairam; Ahmed F Salem; Ranjini K Sundaram; Ranjit S Bindra; Seth B Herzon
Journal: J Am Chem Soc Date: 2016-03-09 Impact factor: 15.419