Literature DB >> 18593

Electronic absorption spectra and protolytic equilibria of doxorubicin: direct spectrophotometric determination of microconstants.

R J Sturgeon, S G Schulman.   

Abstract

The ground- and excited-state dissociation constants and the electronic absorption and fluorescence spectra of doxorubicin were investigated by spectrophotometry. A general method for the direct calculation of individual microscopic dissociation constants was derived using the spectrophotometric data obtained. It was concluded that the protonated amino sugar group is slightly more acidic than the phenolic group. The spectrophotometric data were analyzed, and the macro- and microconstants for the various equilibria was reported.

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Year:  1977        PMID： 18593     DOI： 10.1002/jps.2600660714

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  8 in total

1.  Electron photodetachment dissociation of DNA anions with covalently or noncovalently bound chromophores.

Authors:  Valérie Gabelica; Frédéric Rosu; Edwin De Pauw; Rodolphe Antoine; Thibault Tabarin; Michel Broyer; Philippe Dugourd
Journal:  J Am Soc Mass Spectrom       Date:  2007-08-22       Impact factor: 3.109

2.  Aspects of the chemical stability of doxorubicin and seven other anthracyclines in acidic solution.

Authors:  J H Beijnen; G Wiese; W J Underberg
Journal:  Pharm Weekbl Sci       Date:  1985-06-21

3.  Release, partitioning, and conjugation stability of doxorubicin in polymer micelles determined by mechanistic modeling.

Authors:  Andrei Ponta; Kyle D Fugit; Bradley D Anderson; Younsoo Bae
Journal:  Pharm Res       Date:  2014-11-19       Impact factor: 4.200

4.  Tuning core vs. shell dimensions to adjust the performance of nanoscopic containers for the loading and release of doxorubicin.

Authors:  Lily Yun Lin; Nam S Lee; Jiahua Zhu; Andreas M Nyström; Darrin J Pochan; Richard B Dorshow; Karen L Wooley
Journal:  J Control Release       Date:  2011-01-15       Impact factor: 9.776

5.  Selectivity of the anthracyclines for negatively charged model membranes: role of the amino group.

Authors:  T G Burke; A C Sartorelli; T R Tritton
Journal:  Cancer Chemother Pharmacol       Date:  1988       Impact factor: 3.333

Review 6.  Anthracycline antitumour agents. A review of physicochemical, analytical and stability properties.

Authors:  J Bouma; J H Beijnen; A Bult; W J Underberg
Journal:  Pharm Weekbl Sci       Date:  1986-04-25

7.  Synthesis, characterization and in vitro studies of doxorubicin-loaded magnetic nanoparticles grafted to smart copolymers on A549 lung cancer cell line.

Authors:  Abolfazl Akbarzadeh; Mohammad Samiei; Sang Woo Joo; Maryam Anzaby; Younes Hanifehpour; Hamid Tayefi Nasrabadi; Soodabeh Davaran
Journal:  J Nanobiotechnology       Date:  2012-12-18       Impact factor: 10.435

8.  Possible intermediates in the action of adriamycin--a pulse radiolysis study.

Authors:  E J Land; T Mukherjee; A J Swallow; J M Bruce
Journal:  Br J Cancer       Date:  1985-04       Impact factor: 7.640
  8 in total

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