Literature DB >> 3860797

Aspects of the chemical stability of doxorubicin and seven other anthracyclines in acidic solution.

J H Beijnen, G Wiese, W J Underberg.   

Abstract

The degradation of doxorubicin in acidic medium has been investigated using a stability indicating high pressure liquid chromatographic assay. Influences of temperature, pH and ionic strength on the degradation rate are quantified. The stability of doxorubicin at 50 degrees C is compared with those of seven related anthracyclines. The aglycone degradation products are characterized by mass spectrometry and by chromatography.

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Year:  1985        PMID： 3860797     DOI： 10.1007/bf01968712

Source DB:  PubMed          Journal:  Pharm Weekbl Sci        ISSN： 0167-6555


  19 in total

1.  Adriamycin-a review.

Authors:  S K Carter
Journal:  J Natl Cancer Inst       Date:  1975-12       Impact factor: 13.506

Review 2.  Daunorubicin and adriamycin in cancer treatment: an analysis of their roles and limitations.

Authors:  H L Davis; T E Davis
Journal:  Cancer Treat Rep       Date:  1979-05

3.  Mass spectrometry of some N-acyldaunosamine derivatives.

Authors:  A Vigevani; B Gioia; G Cassinelli
Journal:  Carbohydr Res       Date:  1974-02       Impact factor: 2.104

4.  Photolytic destruction of adriamycin.

Authors:  J P Daugherty; S C Hixon
Journal:  J Pharm Pharmacol       Date:  1981-08       Impact factor: 3.765

5.  Stability kinetics of ginsenosides in aqueous solution.

Authors:  E Miyamoto; S Odashima; I Kitagawa; A Tsuji
Journal:  J Pharm Sci       Date:  1984-03       Impact factor: 3.534

6.  Quantitative determination of adriamycin and daunorubicin-handling of blood and plasma samples.

Authors:  S Eksborg; H Ehrsson; I Wallin; A Lindfors
Journal:  Acta Pharm Suec       Date:  1981

7.  Self-association of doxorubicin and related compounds in aqueous solution.

Authors:  M Menozzi; L Valentini; E Vannini; F Arcamone
Journal:  J Pharm Sci       Date:  1984-06       Impact factor: 3.534

8.  Adriamycin (14-hydroxydaunomycin), a novel antitumor antibiotic.

Authors:  F Arcamone; G Franceschi; S Penco; A Selva
Journal:  Tetrahedron Lett       Date:  1969-03       Impact factor: 2.415

9.  Self-association of daunomycin.

Authors:  J B Chaires; N Dattagupta; D M Crothers
Journal:  Biochemistry       Date:  1982-08-17       Impact factor: 3.162

10.  Initial biotransformations of daunorubicin to aglycones by rat liver microsomes.

Authors:  H S Schwartz; N B Parker
Journal:  Cancer Res       Date:  1981-06       Impact factor: 12.701
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  6 in total

1.  Sterilization of liposomes by heat treatment.

Authors:  N J Zuidam; S S Lee; D J Crommelin
Journal:  Pharm Res       Date:  1993-11       Impact factor: 4.200

Review 2.  Anthracycline antitumour agents. A review of physicochemical, analytical and stability properties.

Authors:  J Bouma; J H Beijnen; A Bult; W J Underberg
Journal:  Pharm Weekbl Sci       Date:  1986-04-25

3.  Stability of solutions of doxorubicin and epirubicin in plastic minibags for intravesical use after storage at -20 degrees C and thawing by microwave radiation.

Authors:  L Keusters; L M Stolk; R Umans; P Van Asten
Journal:  Pharm Weekbl Sci       Date:  1986-06-20

4.  Effect of cyclodextrins on anthracycline stability in acidic aqueous media.

Authors:  O Bekers; J H Beijnen; E H Groot Bramel; M Otagiri; W J Underberg
Journal:  Pharm Weekbl Sci       Date:  1988-10-14

5.  Four new degradation products of doxorubicin: An application of forced degradation study and hyphenated chromatographic techniques.

Authors:  Dheeraj Kaushik; Gulshan Bansal
Journal:  J Pharm Anal       Date:  2015-05-23

6.  Apoferritin as an ubiquitous nanocarrier with excellent shelf life.

Authors:  Simona Dostalova; Katerina Vasickova; David Hynek; Sona Krizkova; Lukas Richtera; Marketa Vaculovicova; Tomas Eckschlager; Marie Stiborova; Zbynek Heger; Vojtech Adam
Journal:  Int J Nanomedicine       Date:  2017-03-24
  6 in total

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