Literature DB >> 18574463

Living on a break: cellular senescence as a DNA-damage response.

Fabrizio d'Adda di Fagagna1.   

Abstract

Cellular senescence is associated with ageing and cancer in vivo and has a proven tumour-suppressive function. Common to both ageing and cancer is the generation of DNA damage and the engagement of the DNA-damage response pathways. In this Review, the diverse mechanisms that lead to DNA-damage generation and the activation of DNA-damage-response signalling pathways are discussed, together with the evidence for their contribution to the establishment and maintenance of cellular senescence in the context of organismal ageing and cancer development.

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Year:  2008        PMID： 18574463     DOI： 10.1038/nrc2440

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  412 in total

Review 1.  Bypassing cellular senescence by genetic screening tools.

Authors:  Mar Vergel; Amancio Carnero
Journal:  Clin Transl Oncol       Date:  2010-06       Impact factor: 3.405

2.  A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts.

Authors:  R Faraonio; P Salerno; F Passaro; C Sedia; A Iaccio; R Bellelli; T C Nappi; M Comegna; S Romano; G Salvatore; M Santoro; F Cimino
Journal:  Cell Death Differ       Date:  2011-11-04       Impact factor: 15.828

3.  Finding Balance: T cell Regulatory Receptor Expression during Aging.

Authors:  Mary M Cavanagh; Qian Qi; Cornelia M Weyand; Jörg J Goronzy
Journal:  Aging Dis       Date:  2011-10-28       Impact factor: 6.745

4.  Signalling the end of the line.

Authors:  John van Tuyn; Peter D Adams
Journal:  Nat Cell Biol       Date:  2012-04-02       Impact factor: 28.824

5.  Terminally differentiated astrocytes lack DNA damage response signaling and are radioresistant but retain DNA repair proficiency.

Authors:  L Schneider; M Fumagalli; F d'Adda di Fagagna
Journal:  Cell Death Differ       Date:  2011-10-07       Impact factor: 15.828

6.  On the origin of prostate fusion oncogenes.

Authors:  Jiri Bartek; Petra Hamerlik; Jiri Lukas
Journal:  Nat Genet       Date:  2010-08       Impact factor: 38.330

Review 7.  Inflammatory networks during cellular senescence: causes and consequences.

Authors:  Adam Freund; Arturo V Orjalo; Pierre-Yves Desprez; Judith Campisi
Journal:  Trends Mol Med       Date:  2010-05-03       Impact factor: 11.951

8.  Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death.

Authors:  Panagiota A Sotiropoulou; Aurélie Candi; Guilhem Mascré; Sarah De Clercq; Khalil Kass Youssef; Gaelle Lapouge; Ellen Dahl; Claudio Semeraro; Geertrui Denecker; Jean-Christophe Marine; Cédric Blanpain
Journal:  Nat Cell Biol       Date:  2010-05-16       Impact factor: 28.824

Review 9.  The essence of senescence.

Authors:  Thomas Kuilman; Chrysiis Michaloglou; Wolter J Mooi; Daniel S Peeper
Journal:  Genes Dev       Date:  2010-11-15       Impact factor: 11.361

10.  Geriatric muscle stem cells switch reversible quiescence into senescence.

Authors:  Pedro Sousa-Victor; Susana Gutarra; Laura García-Prat; Javier Rodriguez-Ubreva; Laura Ortet; Vanessa Ruiz-Bonilla; Mercè Jardí; Esteban Ballestar; Susana González; Antonio L Serrano; Eusebio Perdiguero; Pura Muñoz-Cánoves
Journal:  Nature       Date:  2014-02-12       Impact factor: 49.962
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