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Literature DB >> 22396890

Finding Balance: T cell Regulatory Receptor Expression during Aging.

Mary M Cavanagh¹, Qian Qi, Cornelia M Weyand, Jörg J Goronzy.

Abstract

Aging is associated with a variety of changes to immune responsiveness. Reduced protection against infection, reduced responses to vaccination and increased risk of autoimmunity are all hallmarks of advanced age. Here we consider how changes in the expression of regulatory receptors on the T cell surface contribute to altered immunity during aging.

Entities: Disease

Keywords: Aging; NK receptors; T cell costimulation; T cell regulation; inhibitory receptors

Year: 2011 PMID： 22396890 PMCID： PMC3295076

Source DB: PubMed Journal: Aging Dis ISSN： 2152-5250 Impact factor: 6.745

136 in total

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Journal: Nature Date: 1992-04-16 Impact factor: 49.962

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Authors: A D'Andrea; C Chang; J H Phillips; L L Lanier
Journal: J Exp Med Date: 1996-08-01 Impact factor: 14.307

3. The repertoire of killer cell Ig-like receptor and CD94:NKG2A receptors in T cells: clones sharing identical alpha beta TCR rearrangement express highly diverse killer cell Ig-like receptor patterns.

Authors: M Uhrberg; N M Valiante; N T Young; L L Lanier; J H Phillips; P Parham
Journal: J Immunol Date: 2001-03-15 Impact factor: 5.422

4. Distinct transcriptional control mechanisms of killer immunoglobulin-like receptors in natural killer (NK) and in T cells.

Authors: Jing Xu; Abbe N Vallejo; Yong Jiang; Cornelia M Weyand; Jörg J Goronzy
Journal: J Biol Chem Date: 2005-04-29 Impact factor: 5.157

5. Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression.

Authors: Henry Radziewicz; Chris C Ibegbu; Marina L Fernandez; Kimberly A Workowski; Kamil Obideen; Mohammad Wehbi; Holly L Hanson; James P Steinberg; David Masopust; E John Wherry; John D Altman; Barry T Rouse; Gordon J Freeman; Rafi Ahmed; Arash Grakoui
Journal: J Virol Date: 2006-12-20 Impact factor: 5.103

6. Formation of the killer Ig-like receptor repertoire on CD4+CD28null T cells.

Authors: Melissa R Snyder; Lars-Olof Muegge; Chetan Offord; William M O'Fallon; Zeljko Bajzer; Cornelia M Weyand; Jörg J Goronzy
Journal: J Immunol Date: 2002-04-15 Impact factor: 5.422

7. The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro.

Authors: J W Young; L Koulova; S A Soergel; E A Clark; R M Steinman; B Dupont
Journal: J Clin Invest Date: 1992-07 Impact factor: 14.808

8. Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1).

Authors: David Voehringer; Marie Koschella; Hanspeter Pircher
Journal: Blood Date: 2002-07-12 Impact factor: 22.113

9. Expression of inhibitory KIR is confined to CD8+ effector T cells and limits their proliferative capacity.

Authors: Lionel Arlettaz; Sylvie Degermann; Casimir De Rham; Eddy Roosnek; Bertrand Huard
Journal: Eur J Immunol Date: 2004-12 Impact factor: 5.532

10. A balance between positive and negative signals in cytotoxic lymphocytes regulates the polarization of lipid rafts during the development of cell-mediated killing.

Authors: Z Lou; D Jevremovic; D D Billadeau; P J Leibson
Journal: J Exp Med Date: 2000-01-17 Impact factor: 14.307

15 in total

1. Immune aging and challenges for immune protection of the graying population.

Authors: Abbe N Vallejo
Journal: Aging Dis Date: 2011-10-28 Impact factor: 6.745

Review 2. Immunosenescence: the Role of Aging in the Predisposition to Neuro-Infectious Complications Arising from the Treatment of Multiple Sclerosis.

Authors: Elena Grebenciucova; Joseph R Berger
Journal: Curr Neurol Neurosci Rep Date: 2017-08 Impact factor: 5.081

Review 3. The life cycle of a T cell after vaccination - where does immune ageing strike?

Authors: C Kim; F Fang; C M Weyand; J J Goronzy
Journal: Clin Exp Immunol Date: 2016-08-15 Impact factor: 4.330

Review 4. The immunoinhibitory PD-1/PD-L1 pathway in inflammatory blood vessel disease.

Authors: Cornelia M Weyand; Gerald J Berry; Jörg J Goronzy
Journal: J Leukoc Biol Date: 2017-12-29 Impact factor: 4.962

Review 5. T cell senescence and cardiovascular diseases.

Authors: Hee Tae Yu; Sungha Park; Eui-Cheol Shin; Won-Woo Lee
Journal: Clin Exp Med Date: 2015-07-19 Impact factor: 3.984

Review 6. Understanding immunosenescence to improve responses to vaccines.

Authors: Jörg J Goronzy; Cornelia M Weyand
Journal: Nat Immunol Date: 2013-04-18 Impact factor: 25.606

7. Coordinated regulation of NK receptor expression in the maturing human immune system.

Authors: Dara M Strauss-Albee; Amir Horowitz; Peter Parham; Catherine A Blish
Journal: J Immunol Date: 2014-10-06 Impact factor: 5.422

Review 8. Signaling pathways in aged T cells - a reflection of T cell differentiation, cell senescence and host environment.

Authors: Jörg J Goronzy; Guangjin Li; Mingcan Yu; Cornelia M Weyand
Journal: Semin Immunol Date: 2012-05-04 Impact factor: 11.130

9. The janus head of T cell aging - autoimmunity and immunodeficiency.

Authors: Jörg J Goronzy; Guangjin Li; Zhen Yang; Cornelia M Weyand
Journal: Front Immunol Date: 2013-06-04 Impact factor: 7.561

Review 10. Cytomegalovirus Infection and Memory T Cell Inflation.

Authors: Jihye Kim; A-Reum Kim; Eui-Cheol Shin
Journal: Immune Netw Date: 2015-08-26 Impact factor: 6.303