Literature DB >> 22469830

Signalling the end of the line.

John van Tuyn, Peter D Adams.   

Abstract

Cellular senescence is a stable proliferation arrest induced by triggers such as short telomeres, activated oncogenes and genotoxic stress. Two studies show that cellular senescence induced by genotoxic stress depends on chronic DNA-damage signalling from irreparable damage to telomeres. Hence, dysfunctional or damaged telomeres are the initiators of multiple modes of senescence.

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Year:  2012        PMID： 22469830     DOI： 10.1038/ncb2476

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  16 in total

1.  The serial cultivation of human diploid cell strains.

Authors:  L HAYFLICK; P S MOORHEAD
Journal:  Exp Cell Res       Date:  1961-12       Impact factor: 3.905

Review 2.  Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins.

Authors:  Paula Martínez; María A Blasco
Journal:  Nat Rev Cancer       Date:  2011-03       Impact factor: 60.716

3.  DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

Authors:  A Di Leonardo; S P Linke; K Clarkin; G M Wahl
Journal:  Genes Dev       Date:  1994-11-01       Impact factor: 11.361

4.  Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.

Authors:  Tae-Won Kang; Tetyana Yevsa; Norman Woller; Lisa Hoenicke; Torsten Wuestefeld; Daniel Dauch; Anja Hohmeyer; Marcus Gereke; Ramona Rudalska; Anna Potapova; Marcus Iken; Mihael Vucur; Siegfried Weiss; Mathias Heikenwalder; Sadaf Khan; Jesus Gil; Dunja Bruder; Michael Manns; Peter Schirmacher; Frank Tacke; Michael Ott; Tom Luedde; Thomas Longerich; Stefan Kubicka; Lars Zender
Journal:  Nature       Date:  2011-11-09       Impact factor: 49.962

5.  Telomeres avoid end detection by severing the checkpoint signal transduction pathway.

Authors:  Tiago Carneiro; Lyne Khair; Clara C Reis; Vanessa Borges; Bettina A Moser; Toru M Nakamura; Miguel Godinho Ferreira
Journal:  Nature       Date:  2010-09-09       Impact factor: 49.962

6.  Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

Authors:  Francis Rodier; Jean-Philippe Coppé; Christopher K Patil; Wieteke A M Hoeijmakers; Denise P Muñoz; Saba R Raza; Adam Freund; Eric Campeau; Albert R Davalos; Judith Campisi
Journal:  Nat Cell Biol       Date:  2009-07-13       Impact factor: 28.824

Review 7.  Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence.

Authors:  Peter D Adams
Journal:  Mol Cell       Date:  2009-10-09       Impact factor: 17.970

8.  Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

Authors:  T Kiyono; S A Foster; J I Koop; J K McDougall; D A Galloway; A J Klingelhutz
Journal:  Nature       Date:  1998-11-05       Impact factor: 49.962

9.  Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.

Authors:  Graeme Hewitt; Diana Jurk; Francisco D M Marques; Clara Correia-Melo; Timothy Hardy; Agata Gackowska; Rhys Anderson; Morgan Taschuk; Jelena Mann; João F Passos
Journal:  Nat Commun       Date:  2012-02-28       Impact factor: 14.919

10.  Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.

Authors:  Jean-Philippe Coppé; Christopher K Patil; Francis Rodier; Yu Sun; Denise P Muñoz; Joshua Goldstein; Peter S Nelson; Pierre-Yves Desprez; Judith Campisi
Journal:  PLoS Biol       Date:  2008-12-02       Impact factor: 8.029
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  3 in total

1.  Age-associated defects in EphA2 signaling impair the migration of human cardiac progenitor cells.

Authors:  Polina Goichberg; Ramaswamy Kannappan; Maria Cimini; Yingnan Bai; Fumihiro Sanada; Andrea Sorrentino; Sergio Signore; Jan Kajstura; Marcello Rota; Piero Anversa; Annarosa Leri
Journal:  Circulation       Date:  2013-10-18       Impact factor: 29.690

2.  Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression.

Authors:  Zhenhua Luo; Xuyang Feng; Haoli Wang; Weiyi Xu; Yong Zhao; Wenbin Ma; Songshan Jiang; Dan Liu; Junjiu Huang; Zhou Songyang
Journal:  Aging Cell       Date:  2015-03-06       Impact factor: 9.304

3.  Beyond Telomerase: Telomere Instability as a Novel Target for Cancer Therapy.

Authors:  Maria Fadri-Moskwik; Qing Zhou; Weihang Chai
Journal:  J Mol Genet Med       Date:  2013-12-09
  3 in total

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