Literature DB >> 18553325

The design of polyvalent therapeutics.

Amit Joshi1, David Vance, Prakash Rai, Aditya Thiyagarajan, Ravi S Kane.   

Abstract

This article reviews recent developments in the design of polyvalent ligands for in vivo applications. Topics discussed include the design of polyvalent inhibitors of toxins and viruses, the use of polyvalency for targeted drug delivery and imaging, and applications of polyvalency for enhancing or suppressing immune responses.

Mesh：

Substances：

Year:  2008        PMID： 18553325     DOI： 10.1002/chem.200800278

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  17 in total

Review 1.  Conscripts of the infinite armada: systemic cancer therapy using nanomaterials.

Authors:  David A Scheinberg; Carlos H Villa; Freddy E Escorcia; Michael R McDevitt
Journal:  Nat Rev Clin Oncol       Date:  2010-03-30       Impact factor: 66.675

2.  Designing super selectivity in multivalent nano-particle binding.

Authors:  Francisco J Martinez-Veracoechea; Daan Frenkel
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-20       Impact factor: 11.205

Review 3.  Obstructing toxin pathways by targeted pore blockage.

Authors:  Ekaterina M Nestorovich; Sergey M Bezrukov
Journal:  Chem Rev       Date:  2012-10-11       Impact factor: 60.622

4.  Polyvalent dendrimer-methotrexate as a folate receptor-targeted cancer therapeutic.

Authors:  Thommey P Thomas; Baohua Huang; Seok Ki Choi; Justin E Silpe; Alina Kotlyar; Ankur M Desai; Hong Zong; Jeremy Gam; Melvin Joice; James R Baker
Journal:  Mol Pharm       Date:  2012-08-07       Impact factor: 4.939

Review 5.  Multivalent Inhibitors of Channel-Forming Bacterial Toxins.

Authors:  Goli Yamini; Ekaterina M Nestorovich
Journal:  Curr Top Microbiol Immunol       Date:  2017       Impact factor: 4.291

6.  Photochemical release of methotrexate from folate receptor-targeting PAMAM dendrimer nanoconjugate.

Authors:  Seok Ki Choi; Thommey P Thomas; Ming-Hsin Li; Ankur Desai; Alina Kotlyar; James R Baker
Journal:  Photochem Photobiol Sci       Date:  2012-01-11       Impact factor: 3.982

7.  Genome-free viral capsids as multivalent carriers for taxol delivery.

Authors:  Wesley Wu; Sonny C Hsiao; Zachary M Carrico; Matthew B Francis
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

Review 8.  Polymeric drugs: Advances in the development of pharmacologically active polymers.

Authors:  Jing Li; Fei Yu; Yi Chen; David Oupický
Journal:  J Control Release       Date:  2015-09-26       Impact factor: 9.776

9.  Thermodynamic analysis of multivalent binding of functionalized nanoparticles to membrane surface reveals the importance of membrane entropy and nanoparticle entropy in adhesion of flexible nanoparticles.

Authors:  Samaneh Farokhirad; Ryan P Bradley; Ravi Radhakrishnan
Journal:  Soft Matter       Date:  2019-10-31       Impact factor: 3.679

10.  Design of High-Specificity Nanocarriers by Exploiting Non-Equilibrium Effects in Cancer Cell Targeting.

Authors:  Konstantinos Tsekouras; Igor Goncharenko; Michael E Colvin; Kerwyn Casey Huang; Ajay Gopinathan
Journal:  PLoS One       Date:  2013-06-26       Impact factor: 3.240
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