Literature DB >> 26410809

Polymeric drugs: Advances in the development of pharmacologically active polymers.

Jing Li1, Fei Yu1, Yi Chen1, David Oupický2.   

Abstract

Synthetic polymers play a critical role in pharmaceutical discovery and development. Current research and applications of pharmaceutical polymers are mainly focused on their functions as excipients and inert carriers of other pharmacologically active agents. This review article surveys recent advances in alternative pharmaceutical use of polymers as pharmacologically active agents known as polymeric drugs. Emphasis is placed on the benefits of polymeric drugs that are associated with their macromolecular character and their ability to explore biologically relevant multivalency processes. We discuss the main therapeutic uses of polymeric drugs as sequestrants, antimicrobials, antivirals, and anticancer and anti-inflammatory agents.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Antimicrobials; Antivirals; Cancer; Dendrimers; Drug delivery; Gene delivery; Multivalency; Polymer therapeutics; Polymeric drugs; Polymeric sequestrants; SiRNA delivery; Tumor delivery

Mesh：

Substances：

Year:  2015        PMID： 26410809      PMCID： PMC4656093          DOI： 10.1016/j.jconrel.2015.09.043

Source DB:  PubMed          Journal:  J Control Release        ISSN： 0168-3659            Impact factor:   9.776


  169 in total

1.  The copolymer P(HEMA-co-SS) binds gluten and reduces immune response in gluten-sensitized mice and human tissues.

Authors:  Maud Pinier; Gregor Fuhrmann; Heather J Galipeau; Nathalie Rivard; Joseph A Murray; Chella S David; Hana Drasarova; Ludmila Tuckova; Jean-Christophe Leroux; Elena F Verdu
Journal:  Gastroenterology       Date:  2011-11-10       Impact factor: 22.682

2.  Paclitaxel nanocrystals for overcoming multidrug resistance in cancer.

Authors:  Yang Liu; Leaf Huang; Feng Liu
Journal:  Mol Pharm       Date:  2010-06-07       Impact factor: 4.939

3.  Polymer-Based Therapeutics.

Authors:  Shuang Liu; Ronak Maheshwari; Kristi L Kiick
Journal:  Macromolecules       Date:  2009-01-13       Impact factor: 5.985

4.  Antibacterial and hemolytic activities of pyridinium polymers as a function of the spatial relationship between the positive charge and the pendant alkyl tail.

Authors:  Varun Sambhy; Blake R Peterson; Ayusman Sen
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

Review 5.  New pharmaceutical applications for macromolecular binders.

Authors:  Nicolas Bertrand; Marc A Gauthier; Céline Bouvet; Pierre Moreau; Anne Petitjean; Jean-Christophe Leroux; Jeanne Leblond
Journal:  J Control Release       Date:  2011-05-05       Impact factor: 9.776

6.  European/Canadian multicenter, double-blind, randomized, placebo-controlled study of the effects of glatiramer acetate on magnetic resonance imaging--measured disease activity and burden in patients with relapsing multiple sclerosis. European/Canadian Glatiramer Acetate Study Group.

Authors:  G Comi; M Filippi; J S Wolinsky
Journal:  Ann Neurol       Date:  2001-03       Impact factor: 10.422

7.  Assessment in mice of the therapeutic potential of tailored, multivalent Shiga toxin carbohydrate ligands.

Authors:  George L Mulvey; Paola Marcato; Pavel I Kitov; Joanna Sadowska; David R Bundle; Glen D Armstrong
Journal:  J Infect Dis       Date:  2003-02-07       Impact factor: 5.226

8.  PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial.

Authors:  Sheena McCormack; Gita Ramjee; Anatoli Kamali; Helen Rees; Angela M Crook; Mitzy Gafos; Ute Jentsch; Robert Pool; Maureen Chisembele; Saidi Kapiga; Richard Mutemwa; Andrew Vallely; Thesla Palanee; Yuki Sookrajh; Charles J Lacey; Janet Darbyshire; Heiner Grosskurth; Albert Profy; Andrew Nunn; Richard Hayes; Jonathan Weber
Journal:  Lancet       Date:  2010-09-17       Impact factor: 79.321

9.  Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance.

Authors:  Huijun Zhu; Hongbo Chen; Xiaowei Zeng; Zhongyuan Wang; Xudong Zhang; Yanping Wu; Yongfeng Gao; Jinxie Zhang; Kewei Liu; Ranyi Liu; Lintao Cai; Lin Mei; Si-Shen Feng
Journal:  Biomaterials       Date:  2013-12-19       Impact factor: 12.479

10.  Drug-free macromolecular therapeutics: induction of apoptosis by coiled-coil-mediated cross-linking of antigens on the cell surface.

Authors:  Kuangshi Wu; Jihua Liu; Russell N Johnson; Jiyuan Yang; Jindrich Kopecek
Journal:  Angew Chem Int Ed Engl       Date:  2010-02-15       Impact factor: 15.336
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  18 in total

Review 1.  Nano-engineered delivery systems for cancer imaging and therapy: Recent advances, future direction and patent evaluation.

Authors:  Ghazal Nabil; Ketki Bhise; Samaresh Sau; Mohamed Atef; Hossny A El-Banna; Arun K Iyer
Journal:  Drug Discov Today       Date:  2018-08-16       Impact factor: 7.851

2.  Polymeric chloroquine as an inhibitor of cancer cell migration and experimental lung metastasis.

Authors:  Fei Yu; Jing Li; Ying Xie; Richard L Sleightholm; David Oupický
Journal:  J Control Release       Date:  2016-07-27       Impact factor: 9.776

3.  Chloroquine-Containing HPMA Copolymers as Polymeric Inhibitors of Cancer Cell Migration Mediated by the CXCR4/SDF-1 Chemokine Axis.

Authors:  Fei Yu; Ying Xie; Yan Wang; Zheng-Hong Peng; Jing Li; David Oupický
Journal:  ACS Macro Lett       Date:  2016-02-17       Impact factor: 6.903

Review 4.  Promise of chemokine network-targeted nanoparticles in combination nucleic acid therapies of metastatic cancer.

Authors:  Ying Xie; Yazhe Wang; Jing Li; Yu Hang; David Oupický
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2018-04-26

5.  DenTimol as A Dendrimeric Timolol Analogue for Glaucoma Therapy: Synthesis and Preliminary Efficacy and Safety Assessment.

Authors:  Michael G Lancina; Juan Wang; Geoffrey S Williamson; Hu Yang
Journal:  Mol Pharm       Date:  2018-05-30       Impact factor: 4.939

6.  A prodrug micellar carrier assembled from polymers with pendant farnesyl thiosalicylic acid moieties for improved delivery of paclitaxel.

Authors:  Jingjing Sun; Yichao Chen; Ke Li; Yixian Huang; Xiaofeng Fu; Xiaolan Zhang; Wenchen Zhao; Yuan Wei; Liang Xu; Peijun Zhang; Raman Venkataramanan; Song Li
Journal:  Acta Biomater       Date:  2016-07-12       Impact factor: 8.947

Review 7.  Drug delivery carriers with therapeutic functions.

Authors:  Shuting S Cai; Tianyu Li; Tolulope Akinade; Yuefei Zhu; Kam W Leong
Journal:  Adv Drug Deliv Rev       Date:  2021-07-21       Impact factor: 17.873

8.  Membrane-active macromolecules kill antibiotic-tolerant bacteria and potentiate antibiotics towards Gram-negative bacteria.

Authors:  Divakara S S M Uppu; Mohini M Konai; Paramita Sarkar; Sandip Samaddar; Isabel C M Fensterseifer; Celio Farias-Junior; Paramanandam Krishnamoorthy; Bibek R Shome; Octávio L Franco; Jayanta Haldar
Journal:  PLoS One       Date:  2017-08-24       Impact factor: 3.240

9.  Relationship between Surface Properties and In Vitro Drug Release from Compressed Matrix Containing Polymeric Materials with Different Hydrophobicity Degrees.

Authors:  Cristhian J Yarce; Juan D Echeverri; Mario A Palacio; Carlos A Rivera; Constain H Salamanca
Journal:  Pharmaceuticals (Basel)       Date:  2017-01-24

10.  Cholangiocarcinoma therapy with nanoparticles that combine downregulation of MicroRNA-210 with inhibition of cancer cell invasiveness.

Authors:  Ying Xie; Yazhe Wang; Jing Li; Yu Hang; Lee Jaramillo; Cody J Wehrkamp; Mary Anne Phillippi; Ashley M Mohr; Yi Chen; Geoffrey A Talmon; Justin L Mott; David Oupický
Journal:  Theranostics       Date:  2018-07-30       Impact factor: 11.556
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