Literature DB >> 23057504

Obstructing toxin pathways by targeted pore blockage.

Ekaterina M Nestorovich1, Sergey M Bezrukov.   

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Year:  2012        PMID： 23057504      PMCID： PMC3681896          DOI： 10.1021/cr300141q

Source DB:  PubMed          Journal:  Chem Rev        ISSN： 0009-2665            Impact factor:   60.622


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  586 in total

1.  Dominant-negative mutants of a toxin subunit: an approach to therapy of anthrax.

Authors:  B R Sellman; M Mourez; R J Collier
Journal:  Science       Date:  2001-04-27       Impact factor: 47.728

2.  Asymmetric diffusion through synthetic nanopores.

Authors:  Z Siwy; I D Kosińska; A Fuliński; C R Martin
Journal:  Phys Rev Lett       Date:  2005-02-03       Impact factor: 9.161

3.  Crystal structure of botulinum neurotoxin type A and implications for toxicity.

Authors:  D B Lacy; W Tepp; A C Cohen; B R DasGupta; R C Stevens
Journal:  Nat Struct Biol       Date:  1998-10

4.  Structural determinants for membrane insertion, pore formation and translocation of Clostridium difficile toxin B.

Authors:  Selda Genisyuerek; Panagiotis Papatheodorou; Gregor Guttenberg; Rolf Schubert; Roland Benz; Klaus Aktories
Journal:  Mol Microbiol       Date:  2011-01-28       Impact factor: 3.501

5.  The promoters of the genes for colicin production, release and immunity in the ColA plasmid: effects of convergent transcription and Lex A protein.

Authors:  R Lloubes; D Baty; C Lazdunski
Journal:  Nucleic Acids Res       Date:  1986-03-25       Impact factor: 16.971

6.  Search for cyclodextrin-based inhibitors of anthrax toxins: synthesis, structural features, and relative activities.

Authors:  Vladimir A Karginov; Ekaterina M Nestorovich; Adiamseged Yohannes; Tanisha M Robinson; Nour Eddine Fahmi; Frank Schmidtmann; Sidney M Hecht; Sergey M Bezrukov
Journal:  Antimicrob Agents Chemother       Date:  2006-09-18       Impact factor: 5.191

7.  The staphylococcal leukocidin bicomponent toxin forms large ionic channels.

Authors:  G Miles; S Cheley; O Braha; H Bayley
Journal:  Biochemistry       Date:  2001-07-24       Impact factor: 3.162

8.  Anthrax toxin complexes: heptameric protective antigen can bind lethal factor and edema factor simultaneously.

Authors:  Ruth-Anne L Pimental; Kenneth A Christensen; Bryan A Krantz; R John Collier
Journal:  Biochem Biophys Res Commun       Date:  2004-09-10       Impact factor: 3.575

9.  The protective antigen component of anthrax toxin forms functional octameric complexes.

Authors:  Alexander F Kintzer; Katie L Thoren; Harry J Sterling; Ken C Dong; Geoffrey K Feld; Iok I Tang; Teri T Zhang; Evan R Williams; James M Berger; Bryan A Krantz
Journal:  J Mol Biol       Date:  2009-07-20       Impact factor: 5.469

10.  Cholesterol-dependent pore formation of Clostridium difficile toxin A.

Authors:  Torsten Giesemann; Thomas Jank; Ralf Gerhard; Elke Maier; Ingo Just; Roland Benz; Klaus Aktories
Journal:  J Biol Chem       Date:  2006-03-02       Impact factor: 5.157
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  14 in total

Review 1.  Inhibiting bacterial toxins by channel blockage.

Authors:  Sergey M Bezrukov; Ekaterina M Nestorovich
Journal:  Pathog Dis       Date:  2015-12-09       Impact factor: 3.166

2.  Blocker escape kinetics from a membrane channel analyzed by mapping blocker diffusive dynamics onto a two-site model.

Authors:  Alexander M Berezhkovskii; Sergey M Bezrukov
Journal:  J Chem Phys       Date:  2019-05-21       Impact factor: 3.488

Review 3.  Multivalent Inhibitors of Channel-Forming Bacterial Toxins.

Authors:  Goli Yamini; Ekaterina M Nestorovich
Journal:  Curr Top Microbiol Immunol       Date:  2017       Impact factor: 4.291

Review 4.  Designing inhibitors of anthrax toxin.

Authors:  Ekaterina M Nestorovich; Sergey M Bezrukov
Journal:  Expert Opin Drug Discov       Date:  2014-01-22       Impact factor: 6.098

5.  Exploring the Nature of Cationic Blocker Recognition by the Anthrax Toxin Channel.

Authors:  Sanaz Momben Abolfath; Michelle Kolberg; Vladimir A Karginov; Stephen H Leppla; Ekaterina M Nestorovich
Journal:  Biophys J       Date:  2019-09-12       Impact factor: 4.033

6.  The Transmembrane Domain of a Bicomponent ABC Transporter Exhibits Channel-Forming Activity.

Authors:  Mohammad M Mohammad; Noriko Tomita; Makoto Ohta; Liviu Movileanu
Journal:  ACS Chem Biol       Date:  2016-07-19       Impact factor: 5.100

7.  Probing Translocation in Mutants of the Anthrax Channel: Atomically Detailed Simulations with Milestoning.

Authors:  Piao Ma; Alfredo E Cardenas; Mangesh I Chaudhari; Ron Elber; Susan B Rempe
Journal:  J Phys Chem B       Date:  2018-11-05       Impact factor: 2.991

8.  Design of monodisperse and well-defined polypeptide-based polyvalent inhibitors of anthrax toxin.

Authors:  Sanket Patke; Mohan Boggara; Ronak Maheshwari; Sunit K Srivastava; Manish Arha; Marc Douaisi; Jacob T Martin; Ian B Harvey; Matthew Brier; Tania Rosen; Jeremy Mogridge; Ravi S Kane
Journal:  Angew Chem Int Ed Engl       Date:  2014-04-06       Impact factor: 15.336

Review 9.  Channel-forming bacterial toxins in biosensing and macromolecule delivery.

Authors:  Philip A Gurnev; Ekaterina M Nestorovich
Journal:  Toxins (Basel)       Date:  2014-08-21       Impact factor: 4.546

10.  Tailored cyclodextrin pore blocker protects mammalian cells from clostridium difficile binary toxin CDT.

Authors:  Maurice Roeder; Ekaterina M Nestorovich; Vladimir A Karginov; Carsten Schwan; Klaus Aktories; Holger Barth
Journal:  Toxins (Basel)       Date:  2014-07-15       Impact factor: 4.546
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