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Literature DB >> 18551240

COL1A1 Sp1-binding site polymorphism as a risk factor for genital prolapse.

Andrea Moura Rodrigues¹, Manoel João Batista Castello Girão, Ismael Dale Cotrim Guerreiro da Silva, Marair Gracio Ferreira Sartori, Karina de Falco Martins, Rodrigo de Aquino Castro.

Abstract

The objective of this study was to verify the possible association between the Sp1-binding site polymorphism and genital prolapse. A case-control study was conducted in 107 patients with stages III and IV genital prolapse. The control group included 209 women with stages 0 and I. The polymorphism of type I collagen Sp1-binding site was identified by amplification of the first intron of the COL1A1 gene. We did not find differences in the prevalence of the GT and TT genotypes between the groups (p = 0.34), even when we grouped patients with at least one polymorphic allele (GT and TT) and compared them with patients without the polymorphic allele (GG; p = 0.17) The presence of at least one vaginal delivery, family history for prolapse, and macrosomatic fetus were independent risk factors for prolapse. In conclusion, the COL1A1 Sp1-binding site was not significantly associated with genital prolapse among our study subjects.

Entities: Gene Species

Mesh：

Substances：

Year: 2008 PMID： 18551240 DOI： 10.1007/s00192-008-0662-3

Source DB: PubMed Journal: Int Urogynecol J Pelvic Floor Dysfunct

21 in total

COL1A1 Sp1-binding site polymorphism as a risk factor for genital prolapse.

1. New PCR-based method for the Sp1 site polymorphism in the COL1A1 gene.

2. Analysis of collagen in parametrium and vaginal apex of women with and without uterine prolapse.

3. Procedures for pelvic organ prolapse in the United States, 1979-1997.

Review 4. Functional anatomy of the pelvic floor and lower urinary tract.

5. The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction.

6. Pelvic organ prolapse in nulliparous women and their parous sisters.

7. Polymorphism in the type I collagen (COLIA1) gene and risk of fractures in postmenopausal women.

8. The distribution of pelvic organ support in a population of female subjects seen for routine gynecologic health care.

9. Is growing old a disease? A study of the attitudes of elderly people to physical symptoms.

Review 10. Epidemiology and natural history of pelvic floor dysfunction.

1. Comprehensive analysis of LAMC1 genetic variants in advanced pelvic organ prolapse.

2. Sp1 collagen I A1 polymorphism in women with stress urinary incontinence.

Review 3. Genetics of pelvic organ prolapse: crossing the bridge between bench and bedside in urogynecologic research.

4. Evaluation of COLIA1-1997 G/T polymorphism as a related factor to genital prolapse.

5. COL3A1 2209G>A is a predictor of pelvic organ prolapse.

6. Phenotyping clinical disorders: lessons learned from pelvic organ prolapse.

7. Does COLIA1 SP1-binding site polymorphism predispose women to pelvic organ prolapse?

Review 8. Genetic epidemiology of pelvic organ prolapse: a systematic review.

Review 9. Family history and pelvic organ prolapse: a systematic review and meta-analysis.

10. Polymorphism of a COLIA1 gene Sp1 binding site in Korean women with pelvic organ prolapse.