Literature DB >> 18545427

Three-dimensional in vivo imaging by a handheld dual-axes confocal microscope.

Hyejun Ra1, Wibool Piyawattanametha, Michael J Mandella, Pei-Lin Hsiung, Jonathan Hardy, Thomas D Wang, Christopher H Contag, Gordon S Kino, Olav Solgaard.   

Abstract

We present a handheld dual-axes confocal microscope that is based on a two-dimensional microelectromechanical systems (MEMS) scanner. It performs reflectance and fluorescence imaging at 488 nm wavelength, with three-dimensional imaging capability. The fully packaged microscope has a diameter of 10 mm and acquires images at 4 Hz frame rate with a maximum field of view of 400 microm x 260 microm. The transverse and axial resolutions of the handheld probe are 1.7 microm and 5.8 microm, respectively. Capability to perform real time small animal imaging is demonstrated in vivo in transgenic mice.

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Year:  2008        PMID： 18545427      PMCID： PMC2596951          DOI： 10.1364/oe.16.007224

Source DB:  PubMed          Journal:  Opt Express        ISSN： 1094-4087            Impact factor:   3.894


  6 in total

1.  Dual-axis confocal microscope for high-resolution in vivo imaging.

Authors:  Thomas D Wang; Michael J Mandella; Christopher H Contag; Gordon S Kino
Journal:  Opt Lett       Date:  2003-03-15       Impact factor: 3.776

2.  Micromachined transmissive scanning confocal microscope.

Authors:  Sunghoon Kwon; Luke P Lee
Journal:  Opt Lett       Date:  2004-04-01       Impact factor: 3.776

3.  Miniature near-infrared dual-axes confocal microscope utilizing a two-dimensional microelectromechanical systems scanner.

Authors:  Jonathan T C Liu; Michael J Mandella; Hyejun Ra; Larry K Wong; Olav Solgaard; Gordon S Kino; Wibool Piyawattanametha; Christopher H Contag; Thomas D Wang
Journal:  Opt Lett       Date:  2007-02-01       Impact factor: 3.776

4.  Improved rejection of multiply scattered photons in confocal microscopy using dual-axes architecture.

Authors:  Larry K Wong; Michael J Mandella; Gordon S Kino; Thomas D Wang
Journal:  Opt Lett       Date:  2007-06-15       Impact factor: 3.776

5.  Fiber-optic confocal microscope using a MEMS scanner and miniature objective lens.

Authors:  Hyun-Joon Shin; Mark C Pierce; Daesung Lee; Hyejun Ra; Olav Solgaard; Rebecca Richards-Kortum
Journal:  Opt Express       Date:  2007-07-23       Impact factor: 3.894

6.  Generating green fluorescent mice by germline transmission of green fluorescent ES cells.

Authors:  A K Hadjantonakis; M Gertsenstein; M Ikawa; M Okabe; A Nagy
Journal:  Mech Dev       Date:  1998-08       Impact factor: 1.882
  6 in total
  21 in total

1.  Micromirror-scanned dual-axis confocal microscope utilizing a gradient-index relay lens for image guidance during brain surgery.

Authors:  Jonathan T C Liu; Michael J Mandella; Nathan O Loewke; Henry Haeberle; Hyejun Ra; Wibool Piyawattanametha; Olav Solgaard; Gordon S Kino; Christopher H Contag
Journal:  J Biomed Opt       Date:  2010 Mar-Apr       Impact factor: 3.170

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Review 3.  Optical contrast agents and imaging systems for detection and diagnosis of cancer.

Authors:  Mark C Pierce; David J Javier; Rebecca Richards-Kortum
Journal:  Int J Cancer       Date:  2008-11-01       Impact factor: 7.396

4.  Smart-phone based computational microscopy using multi-frame contact imaging on a fiber-optic array.

Authors:  Isa Navruz; Ahmet F Coskun; Justin Wong; Saqib Mohammad; Derek Tseng; Richie Nagi; Stephen Phillips; Aydogan Ozcan
Journal:  Lab Chip       Date:  2013-08-12       Impact factor: 6.799

Review 5.  Invited review article: Imaging techniques for harmonic and multiphoton absorption fluorescence microscopy.

Authors:  Ramón Carriles; Dawn N Schafer; Kraig E Sheetz; Jeffrey J Field; Richard Cisek; Virginijus Barzda; Anne W Sylvester; Jeffrey A Squier
Journal:  Rev Sci Instrum       Date:  2009-08       Impact factor: 1.523

6.  Miniaturized fiber-coupled confocal fluorescence microscope with an electrowetting variable focus lens using no moving parts.

Authors:  Baris N Ozbay; Justin T Losacco; Robert Cormack; Richard Weir; Victor M Bright; Juliet T Gopinath; Diego Restrepo; Emily A Gibson
Journal:  Opt Lett       Date:  2015-06-01       Impact factor: 3.776

7.  The potential of fluorescent dyes-comparative study of Nile red and three derivatives for the detection of microplastics.

Authors:  Michael T Sturm; Harald Horn; Katrin Schuhen
Journal:  Anal Bioanal Chem       Date:  2021-01-07       Impact factor: 4.142

Review 8.  Trends in fluorescence image-guided surgery for gliomas.

Authors:  Jonathan T C Liu; Daphne Meza; Nader Sanai
Journal:  Neurosurgery       Date:  2014-07       Impact factor: 4.654

9.  Pilot Clinical Evaluation of a Confocal Microlaparoscope for Ovarian Cancer Detection.

Authors:  Matthew D Risi; Andrew R Rouse; Setsuko K Chambers; Kenneth D Hatch; Wenxin Zheng; Arthur F Gmitro
Journal:  Int J Gynecol Cancer       Date:  2016-02       Impact factor: 3.437

Review 10.  Optical imaging techniques for point-of-care diagnostics.

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Journal:  Lab Chip       Date:  2012-10-09       Impact factor: 6.799
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