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Literature DB >> 17215937

Miniature near-infrared dual-axes confocal microscope utilizing a two-dimensional microelectromechanical systems scanner.

Jonathan T C Liu¹, Michael J Mandella, Hyejun Ra, Larry K Wong, Olav Solgaard, Gordon S Kino, Wibool Piyawattanametha, Christopher H Contag, Thomas D Wang.

Abstract

The first, to our knowledge, miniature dual-axes confocal microscope has been developed, with an outer diameter of 10 mm, for subsurface imaging of biological tissues with 5-7 microm resolution. Depth-resolved en face images are obtained at 30 frames per second, with a field of view of 800 x 100 microm, by employing a two-dimensional scanning microelectromechanical systems mirror. Reflectance and fluorescence images are obtained with a laser source at 785 nm, demonstrating the ability to perform real-time optical biopsy.

Mesh：

Year: 2007 PMID： 17215937 PMCID： PMC2104518 DOI： 10.1364/ol.32.000256

Source DB: PubMed Journal: Opt Lett ISSN： 0146-9592 Impact factor: 3.776

5 in total

1. Dual-axis confocal microscope for high-resolution in vivo imaging.

Authors: Thomas D Wang; Michael J Mandella; Christopher H Contag; Gordon S Kino
Journal: Opt Lett Date: 2003-03-15 Impact factor: 3.776

2. Design of a high-numerical-aperture miniature microscope objective for an endoscopic fiber confocal reflectance microscope.

Authors: Chen Liang; Kung-Bin Sung; Rebecca R Richards-Kortum; Michael R Descour
Journal: Appl Opt Date: 2002-08-01 Impact factor: 1.980

3. Fast-scanning two-photon fluorescence imaging based on a microelectromechanical systems two- dimensional scanning mirror.

Authors: Wibool Piyawattanametha; Robert P J Barretto; Tony H Ko; Benjamin A Flusberg; Eric D Cocker; Hyejun Ra; Daesung Lee; Olav Solgaard; Mark J Schnitzer
Journal: Opt Lett Date: 2006-07-01 Impact factor: 3.776

4. Dual-axes confocal reflectance microscope for distinguishing colonic neoplasia.

Authors: Jonathan T C Liu; Michael J Mandella; Shai Friedland; Roy Soetikno; James M Crawford; Christopher H Contag; Gordon S Kino; Thomas D Wang
Journal: J Biomed Opt Date: 2006 Sep-Oct Impact factor: 3.170

5. Confocal microscope with large field and working distance.

Authors: R H Webb; F Rogomentich
Journal: Appl Opt Date: 1999-08-01 Impact factor: 1.980

5 in total

28 in total

1. Micromirror-scanned dual-axis confocal microscope utilizing a gradient-index relay lens for image guidance during brain surgery.

Authors: Jonathan T C Liu; Michael J Mandella; Nathan O Loewke; Henry Haeberle; Hyejun Ra; Wibool Piyawattanametha; Olav Solgaard; Gordon S Kino; Christopher H Contag
Journal: J Biomed Opt Date: 2010 Mar-Apr Impact factor: 3.170

Review 2. Future and advances in endoscopy.

Authors: Sakib F Elahi; Thomas D Wang
Journal: J Biophotonics Date: 2011-07-13 Impact factor: 3.207

Miniature near-infrared dual-axes confocal microscope utilizing a two-dimensional microelectromechanical systems scanner.

1. Dual-axis confocal microscope for high-resolution in vivo imaging.

2. Design of a high-numerical-aperture miniature microscope objective for an endoscopic fiber confocal reflectance microscope.

3. Fast-scanning two-photon fluorescence imaging based on a microelectromechanical systems two- dimensional scanning mirror.

4. Dual-axes confocal reflectance microscope for distinguishing colonic neoplasia.

5. Confocal microscope with large field and working distance.

1. Micromirror-scanned dual-axis confocal microscope utilizing a gradient-index relay lens for image guidance during brain surgery.

Review 2. Future and advances in endoscopy.

3. Three-dimensional in vivo imaging by a handheld dual-axes confocal microscope.

Review 4. Basic science research in pediatric radiology - how to empower the leading edge of our field.

Review 5. Trends in fluorescence image-guided surgery for gliomas.

6. Comparison of line-scanned and point-scanned dual-axis confocal microscope performance.

7. High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe.

8. Quantifying cell-surface biomarker expression in thick tissues with ratiometric three-dimensional microscopy.

9. Miniature in vivo MEMS-based line-scanned dual-axis confocal microscope for point-of-care pathology.

Review 10. Optical imaging techniques for point-of-care diagnostics.