Literature DB >> 18499250

The PHD domain of the sea urchin RAG2 homolog, SpRAG2L, recognizes dimethylated lysine 4 in histone H3 tails.

David R Wilson1, Darrell D Norton, Sebastian D Fugmann.   

Abstract

V(D)J recombination is a somatic gene rearrangement process that assembles antigen receptor genes from individual segments during lymphocyte development. The access of the RAG1/RAG2 recombinase to these gene segments is regulated at the level of chromatin modifications, in particular histone tail modifications. Trimethylation of lysine 4 in histone H3 (H3K4me3) correlates with actively recombining gene elements, and this mark is recognized and interpreted by the plant homeodomain (PHD) of RAG2. Here we report that the PHD domain of the only known invertebrate homolog of RAG2, the SpRAG2L protein of the purple sea urchin (Strongylocentrotus purpuratus) also binds to methylated histones, but with a unique preference for H3K4me2. While the cognate substrate for the sea urchin RAG1L/RAG2L complex remains elusive, the affinity for histone tails and the nuclear localization of ectopically expressed SpRAG2L strongly support the model that this enzyme complex exerts its activity on DNA in the context of chromatin.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18499250      PMCID： PMC2518978          DOI： 10.1016/j.dci.2008.03.012

Source DB:  PubMed          Journal:  Dev Comp Immunol        ISSN： 0145-305X            Impact factor:   3.636


  40 in total

Review 1.  The RAG proteins and V(D)J recombination: complexes, ends, and transposition.

Authors:  S D Fugmann; A I Lee; P E Shockett; I J Villey; D G Schatz
Journal:  Annu Rev Immunol       Date:  2000       Impact factor: 28.527

Review 2.  Factors and forces controlling V(D)J recombination.

Authors:  D G Hesslein; D G Schatz
Journal:  Adv Immunol       Date:  2001       Impact factor: 3.543

Review 3.  The mechanism and regulation of chromosomal V(D)J recombination.

Authors:  Craig H Bassing; Wojciech Swat; Frederick W Alt
Journal:  Cell       Date:  2002-04       Impact factor: 41.582

4.  Histone 3 lysine 4 methylation during the pre-B to immature B-cell transition.

Authors:  Eric J Perkins; Barbara L Kee; Dale A Ramsden
Journal:  Nucleic Acids Res       Date:  2004-03-29       Impact factor: 16.971

5.  V(D)J recombination signal recognition: distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2.

Authors:  P C Swanson; S Desiderio
Journal:  Immunity       Date:  1998-07       Impact factor: 31.745

6.  Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences.

Authors:  Y Akamatsu; M A Oettinger
Journal:  Mol Cell Biol       Date:  1998-08       Impact factor: 4.272

Review 7.  V(D)J recombination: RAG proteins, repair factors, and regulation.

Authors:  Martin Gellert
Journal:  Annu Rev Biochem       Date:  2001-11-09       Impact factor: 23.643

8.  Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4.

Authors:  Katrina B Morshead; David N Ciccone; Sean D Taverna; C David Allis; Marjorie A Oettinger
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-19       Impact factor: 11.205

9.  The V(D)J recombination activating protein RAG2 consists of a six-bladed propeller and a PHD fingerlike domain, as revealed by sequence analysis.

Authors:  I Callebaut; J P Mornon
Journal:  Cell Mol Life Sci       Date:  1998-08       Impact factor: 9.261

10.  ADP-ribosylation factor 6 regulates a novel plasma membrane recycling pathway.

Authors:  H Radhakrishna; J G Donaldson
Journal:  J Cell Biol       Date:  1997-10-06       Impact factor: 10.539
View more
  8 in total

1.  Phf7 controls male sex determination in the Drosophila germline.

Authors:  Shu Yuan Yang; Ellen M Baxter; Mark Van Doren
Journal:  Dev Cell       Date:  2012-05-15       Impact factor: 12.270

Review 2.  The origins of vertebrate adaptive immunity.

Authors:  Gary W Litman; Jonathan P Rast; Sebastian D Fugmann
Journal:  Nat Rev Immunol       Date:  2010-08       Impact factor: 53.106

Review 3.  Structural insights into the evolution of the RAG recombinase.

Authors:  Chang Liu; Yuhang Zhang; Catherine C Liu; David G Schatz
Journal:  Nat Rev Immunol       Date:  2021-10-21       Impact factor: 108.555

Review 4.  The origins of the Rag genes--from transposition to V(D)J recombination.

Authors:  Sebastian D Fugmann
Journal:  Semin Immunol       Date:  2009-12-09       Impact factor: 11.130

5.  Construction of a medicinal leech transcriptome database and its application to the identification of leech homologs of neural and innate immune genes.

Authors:  Eduardo R Macagno; Terry Gaasterland; Lee Edsall; Vineet Bafna; Marcelo B Soares; Todd Scheetz; Thomas Casavant; Corinne Da Silva; Patrick Wincker; Aurélie Tasiemski; Michel Salzet
Journal:  BMC Genomics       Date:  2010-06-25       Impact factor: 3.969

Review 6.  New insights into the evolutionary origins of the recombination-activating gene proteins and V(D)J recombination.

Authors:  Lina Marcela Carmona; David G Schatz
Journal:  FEBS J       Date:  2017-01-06       Impact factor: 5.542

7.  Guardian of the Genome: An Alternative RAG/Transib Co-Evolution Hypothesis for the Origin of V(D)J Recombination.

Authors:  Iryna Yakovenko; Jacob Agronin; L Courtney Smith; Matan Oren
Journal:  Front Immunol       Date:  2021-07-28       Impact factor: 7.561

8.  Identification of RAG-like transposons in protostomes suggests their ancient bilaterian origin.

Authors:  Eliza C Martin; Célia Vicari; Louis Tsakou-Ngouafo; Pierre Pontarotti; Andrei J Petrescu; David G Schatz
Journal:  Mob DNA       Date:  2020-05-06
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.