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Literature DB >> 11983152

The mechanism and regulation of chromosomal V(D)J recombination.

Craig H Bassing¹, Wojciech Swat, Frederick W Alt.

Abstract

V(D)J recombination is of fundamental importance to the generation of diverse antigen receptor repertoires. We review our current understanding of the V(D)J recombination reaction and how it is regulated during lymphocyte development. We also discuss how defects in the mechanism or regulation of V(D)J recombination can lead to human disease.

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Year: 2002 PMID： 11983152 DOI： 10.1016/s0092-8674(02)00675-x

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

343 in total

1. The RAG1 N-terminal domain is an E3 ubiquitin ligase.

Authors: Vyacheslav Yurchenko; Zhu Xue; Moshe Sadofsky
Journal: Genes Dev Date: 2003-03-01 Impact factor: 11.361

2. T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes.

Authors: Craig H Bassing; Robert E Tillman; Barbara B Woodman; David Canty; Robert J Monroe; Barry P Sleckman; Frederick W Alt
Journal: Proc Natl Acad Sci U S A Date: 2003-02-25 Impact factor: 11.205

3. The C-terminal portion of RAG2 protects against transposition in vitro.

Authors: Sheryl K Elkin; Adam G Matthews; Marjorie A Oettinger
Journal: EMBO J Date: 2003-04-15 Impact factor: 11.598

4. Dual functions of Nbs1 in the repair of DNA breaks and proliferation ensure proper V(D)J recombination and T-cell development.

Authors: Amal Saidi; Tangliang Li; Falk Weih; Patrick Concannon; Zhao-Qi Wang
Journal: Mol Cell Biol Date: 2010-10-04 Impact factor: 4.272

The mechanism and regulation of chromosomal V(D)J recombination.

1. The RAG1 N-terminal domain is an E3 ubiquitin ligase.

2. T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes.

3. The C-terminal portion of RAG2 protects against transposition in vitro.

4. Dual functions of Nbs1 in the repair of DNA breaks and proliferation ensure proper V(D)J recombination and T-cell development.

Review 5. Adaptive immune responses mediated by natural killer cells.

Review 6. Role of recombination activating genes in the generation of antigen receptor diversity and beyond.

7. Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity.

8. Proteasome activator PA200 is required for normal spermatogenesis.

9. Regulation of V(D)J recombination by nucleosome positioning at recombination signal sequences.

10. Functional overlap in the cis-acting regulation of the V(D)J recombination at the TCRbeta locus.