Literature DB >> 1849658

Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta.

J D Zhang1, L S Cousens, P J Barr, S R Sprang.   

Abstract

The three-dimensional structure of the 146-residue form of human basic fibroblast growth factor (bFGF), expressed as a recombinant protein in yeast, has been determined by x-ray crystallography to a resolution of 1.8 A. bFGF is composed entirely of beta-sheet structure, comprising a three-fold repeat of a four-stranded antiparallel beta-meander. The topology of bFGF is identical to that of interleukin 1 beta, showing that although the two proteins share only 10% sequence identity, bFGF, interleukin 1, and their homologs comprise a family of structurally related mitogenic factors. Analysis of the three-dimensional structure in light of functional studies of bFGF suggests that the receptor binding site and the positively charged heparin binding site correspond to adjacent but separate loci on the beta-barrel.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1849658      PMCID： PMC51464          DOI： 10.1073/pnas.88.8.3446

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  36 in total

1.  The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.

Authors:  M J Eck; S R Sprang
Journal:  J Biol Chem       Date:  1989-10-15       Impact factor: 5.157

Review 2.  Growth factors in early embryogenesis.

Authors:  M Whitman; D A Melton
Journal:  Annu Rev Cell Biol       Date:  1989

3.  Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family.

Authors:  I Marics; J Adelaide; F Raybaud; M G Mattei; F Coulier; J Planche; O de Lapeyriere; D Birnbaum
Journal:  Oncogene       Date:  1989-03       Impact factor: 9.867

4.  Expression and processing of biologically active fibroblast growth factors in the yeast Saccharomyces cerevisiae.

Authors:  P J Barr; L S Cousens; C T Lee-Ng; A Medina-Selby; F R Masiarz; R A Hallewell; S H Chamberlain; J D Bradley; D Lee; K S Steimer
Journal:  J Biol Chem       Date:  1988-11-05       Impact factor: 5.157

5.  Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth.

Authors:  P W Finch; J S Rubin; T Miki; D Ron; S A Aaronson
Journal:  Science       Date:  1989-08-18       Impact factor: 47.728

6.  Crystallographic refinement of interleukin 1 beta at 2.0 A resolution.

Authors:  J P Priestle; H P Schär; M G Grütter
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

7.  Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor.

Authors:  P L Lee; D E Johnson; L S Cousens; V A Fried; L T Williams
Journal:  Science       Date:  1989-07-07       Impact factor: 47.728

8.  Basic fibroblast growth factor is a substrate for protein phosphorylation and is phosphorylated by capillary endothelial cells in culture.

Authors:  J J Feige; A Baird
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

9.  Neutralizing antibodies inhibit the binding of basic fibroblast growth factor to its receptor but not to heparin.

Authors:  M Kurokawa; S R Doctrow; M Klagsbrun
Journal:  J Biol Chem       Date:  1989-05-05       Impact factor: 5.157

10.  Reductive methylation of lysine residues in acidic fibroblast growth factor: effect on mitogenic activity and heparin affinity.

Authors:  J W Harper; R R Lobb
Journal:  Biochemistry       Date:  1988-01-26       Impact factor: 3.162
View more
  52 in total

1.  Molecular characteristics of fibroblast growth factor-fibroblast growth factor receptor-heparin-like glycosaminoglycan complex.

Authors:  G Venkataraman; R Raman; V Sasisekharan; R Sasisekharan
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205

2.  Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor.

Authors:  Regina Goetz; Mutsuko Ohnishi; Serkan Kir; Hiroshi Kurosu; Lei Wang; Johanne Pastor; Jinghong Ma; Weiming Gai; Makoto Kuro-o; Mohammed S Razzaque; Moosa Mohammadi
Journal:  J Biol Chem       Date:  2012-06-25       Impact factor: 5.157

3.  Multiple routes lead to the native state in the energy landscape of the beta-trefoil family.

Authors:  Leslie L Chavez; Shachi Gosavi; Patricia A Jennings; José N Onuchic
Journal:  Proc Natl Acad Sci U S A       Date:  2006-06-26       Impact factor: 11.205

4.  Structure of calcium-bound human S100A13 at pH 7.5 at 1.8 A resolution.

Authors:  Fabiana Lica Imai; Koji Nagata; Naoto Yonezawa; Minoru Nakano; Masaru Tanokura
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2008-01-31

Review 5.  Overview of protein structural and functional folds.

Authors:  Peter D Sun; Christine E Foster; Jeffrey C Boyington
Journal:  Curr Protoc Protein Sci       Date:  2004-05

6.  Identification of heparin-binding sites in proteins by selective labeling.

Authors:  Alessandro Ori; Paul Free; José Courty; Mark C Wilkinson; David G Fernig
Journal:  Mol Cell Proteomics       Date:  2009-06-30       Impact factor: 5.911

7.  Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

Authors:  P M Smallwood; I Munoz-Sanjuan; P Tong; J P Macke; S H Hendry; D J Gilbert; N G Copeland; N A Jenkins; J Nathans
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-03       Impact factor: 11.205

8.  Interactions of putative heparin-binding domains of basic fibroblast growth factor and its receptor, FGFR-1, with heparin using synthetic peptides.

Authors:  L Kinsella; H L Chen; J A Smith; P S Rudland; D G Fernig
Journal:  Glycoconj J       Date:  1998-04       Impact factor: 2.916

9.  Crystallization and preliminary X-ray analysis of human S100A13.

Authors:  Fabiana Lica Imai; Koji Nagata; Naoto Yonezawa; Jinyan Yu; Eriko Ito; Saeko Kanai; Masaru Tanokura; Minoru Nakano
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2006-10-20

10.  Formulation design of acidic fibroblast growth factor.

Authors:  P K Tsai; D B Volkin; J M Dabora; K C Thompson; M W Bruner; J O Gress; B Matuszewska; M Keogan; J V Bondi; C R Middaugh
Journal:  Pharm Res       Date:  1993-05       Impact factor: 4.200
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.