Literature DB >> 18482694

Computational design of enzymes.

Reinhard Sterner1, Rainer Merkl, Frank M Raushel.   

Abstract

The de novo design of enzymes with activities not found in natural biocatalysts is a major challenge for molecular biology. Sophisticated computational methods have recently led to impressive progress in this exciting and rapidly evolving field (Röthlisberger et al., 2008; Jiang et al., 2008).

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Year:  2008        PMID: 18482694     DOI: 10.1016/j.chembiol.2008.04.007

Source DB:  PubMed          Journal:  Chem Biol        ISSN: 1074-5521


  7 in total

Review 1.  Directed evolution drives the next generation of biocatalysts.

Authors:  Nicholas J Turner
Journal:  Nat Chem Biol       Date:  2009-08       Impact factor: 15.040

2.  Co-evolution of β-glucosidase activity and product tolerance for increasing cellulosic ethanol yield.

Authors:  Kexin Wang; Qiuxia Huang; Hanxin Li; Xihua Zhao
Journal:  Biotechnol Lett       Date:  2020-06-24       Impact factor: 2.461

3.  Insights from molecular dynamics simulations for computational protein design.

Authors:  Matthew Carter Childers; Valerie Daggett
Journal:  Mol Syst Des Eng       Date:  2017-01-09

4.  The influence of protein dynamics on the success of computational enzyme design.

Authors:  Jory Z Ruscio; Jonathan E Kohn; K Aurelia Ball; Teresa Head-Gordon
Journal:  J Am Chem Soc       Date:  2009-10-07       Impact factor: 15.419

5.  Designing new cellular signaling pathways.

Authors:  Peter M Pryciak
Journal:  Chem Biol       Date:  2009-03-27

Review 6.  Step-by-step design of proteins for small molecule interaction: A review on recent milestones.

Authors:  José M Pereira; Maria Vieira; Sérgio M Santos
Journal:  Protein Sci       Date:  2021-05-10       Impact factor: 6.993

7.  TransCent: computational enzyme design by transferring active sites and considering constraints relevant for catalysis.

Authors:  André Fischer; Nils Enkler; Gerd Neudert; Marco Bocola; Reinhard Sterner; Rainer Merkl
Journal:  BMC Bioinformatics       Date:  2009-02-10       Impact factor: 3.169

  7 in total

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