BACKGROUND AND PURPOSE: Intracranial aneurysm (IA) treatment through hemodynamic modification with novel stent designs is a burgeoning area of research. We present a feasibility study for a new low-porosity patch-containing stent designed to treat intracranial aneurysms. The device is deployed so the patch covers the aneurysm neck ensuring strong flow diversion away from the aneurysm while keeping a low probability of occlusion of perforating vessels. METHODS: We created 17 side-wall aneurysms in 6 dogs, 2 per carotid artery if animal size permitted. Twelve proximal aneurysms were treated with AVSs: 5 distal aneurysms were untreated, serving as controls against self-thrombosis; 7 treated aneurysms were fully-covered; and 5 were partially-covered. After 4 weeks, a final angiogram was performed and aneurysms were explanted. Angiograms acquired pre- and posttreatment and at 4-week follow-up were analyzed quantitatively using normalized time-density curves (NTDC). Cone-beam micro-CT and histological specimen analysis were then performed. RESULTS: Posttreatment, NTDC average peaks dropped to 45% of initial values for the partially-covered aneurysms and 78% for the fully-covered aneurysms. Cone-beam micro-CT imaging performed at 4 weeks posttreatment showed partial thrombosis in 4 of 5 partially-covered aneurysms and complete thrombosis in all fully-covered aneurysms. Histology revealed neointimal coverage of all asymmetrical patch regions and thrombus formation in both fully- and partially-covered aneurysms. Four-week follow-up was not done for 1 animal (2 controls, 2 treated) that expired because of groin hemorrhage and for another animal (1 aneurysm) with an occluded carotid. CONCLUSIONS: We demonstrate aneurysmal blood flow diversion using a new low-porosity patch-containing asymmetrical vascular stent in a canine side-wall aneurysm model. Overall results are encouraging and support continued AVS development.
BACKGROUND AND PURPOSE:Intracranial aneurysm (IA) treatment through hemodynamic modification with novel stent designs is a burgeoning area of research. We present a feasibility study for a new low-porosity patch-containing stent designed to treat intracranial aneurysms. The device is deployed so the patch covers the aneurysm neck ensuring strong flow diversion away from the aneurysm while keeping a low probability of occlusion of perforating vessels. METHODS: We created 17 side-wall aneurysms in 6 dogs, 2 per carotid artery if animal size permitted. Twelve proximal aneurysms were treated with AVSs: 5 distal aneurysms were untreated, serving as controls against self-thrombosis; 7 treated aneurysms were fully-covered; and 5 were partially-covered. After 4 weeks, a final angiogram was performed and aneurysms were explanted. Angiograms acquired pre- and posttreatment and at 4-week follow-up were analyzed quantitatively using normalized time-density curves (NTDC). Cone-beam micro-CT and histological specimen analysis were then performed. RESULTS: Posttreatment, NTDC average peaks dropped to 45% of initial values for the partially-covered aneurysms and 78% for the fully-covered aneurysms. Cone-beam micro-CT imaging performed at 4 weeks posttreatment showed partial thrombosis in 4 of 5 partially-covered aneurysms and complete thrombosis in all fully-covered aneurysms. Histology revealed neointimal coverage of all asymmetrical patch regions and thrombus formation in both fully- and partially-covered aneurysms. Four-week follow-up was not done for 1 animal (2 controls, 2 treated) that expired because of groin hemorrhage and for another animal (1 aneurysm) with an occluded carotid. CONCLUSIONS: We demonstrate aneurysmal blood flow diversion using a new low-porosity patch-containing asymmetrical vascular stent in a canine side-wall aneurysm model. Overall results are encouraging and support continued AVS development.
Authors: Ciprian N Ionita; Keneth R Hoffmann; Daniel R Bednarek; Ravishankar Chityala; Stephen Rudin Journal: J Digit Imaging Date: 2007-02-28 Impact factor: 4.056
Authors: Zhou Wang; Ciprian Ionita; Stephen Rudin; Kenneth R Hoffmann; Adam B Paxton; Daniel R Bednarek Journal: Proc SPIE Int Soc Opt Eng Date: 2004-04
Authors: Timo Krings; Franz J Hans; Walter Möller-Hartmann; Anna Brunn; Ruth Thiex; Thomas Schmitz-Rode; Peter Verken; Kira Scherer; Heiko Dreeskamp; Klaus P Stein; Joachim Gilsbach; Armin Thron Journal: Neurosurgery Date: 2005-06 Impact factor: 4.654
Authors: Stephen Rudin; Zhou Wang; Iacovos Kyprianou; Kenneth R Hoffmann; Ye Wu; Hui Meng; Lee R Guterman; Balazs Nemes; Daniel R Bednarek; Jacek Dmochowski; L Nelson Hopkins Journal: Radiology Date: 2004-04 Impact factor: 11.105
Authors: C N Ionita; S K Natarajan; W Wang; L N Hopkins; E I Levy; A H Siddiqui; D R Bednarek; S Rudin Journal: AJNR Am J Neuroradiol Date: 2011-07-14 Impact factor: 3.825
Authors: Ciprian N Ionita; Himanshu Suri; Sabareesh Nataranjian; Adnan Siddiqui; Elad Levy; Nelson L Hopkins; Daniel R Bednarek; Stephen Rudin Journal: Proc SPIE Int Soc Opt Eng Date: 2011
Authors: Aradhana Yoganand; Rachel P Wood; Carlos Jimenez; Adnan Siddiqui; Kenneth Snyder; S V Setlur Nagesh; D R Bednarek; S Rudin; Robert Baier; Ciprian N Ionita Journal: Proc SPIE Int Soc Opt Eng Date: 2015-03-17
Authors: Ciprian N Ionita; Andreea Dohatcu; Andrey Sinelnikov; Jason Sherman; Christos Keleshis; Ann M Paciorek; K R Hoffmann; D R Bednarek; S Rudin Journal: Proc SPIE Int Soc Opt Eng Date: 2009-01-01
Authors: Ciprian N Ionita; Ann M Paciorek; Andreea Dohatcu; Kenneth R Hoffmann; Daniel R Bednarek; John Kolega; Elad I Levy; L Nelson Hopkins; Stephen Rudin; J Duffy Mocco Journal: Stroke Date: 2009-01-08 Impact factor: 7.914