Literature DB >> 18432411

Epigenetics, aging, and autoimmunity.

Raymond L Yung1, Annabelle Julius.   

Abstract

Immune senescence is associated with a decline in T- and B-cell immune responses. It is, therefore, perhaps surprising that aging is linked to the appearance of serological and clinical autoimmunity. Here we review the mechanisms that contribute to the increase in inflammatory and autoimmune responses in aging. The bulk of this review will focus on aging-associated changes in epigenetic mechanisms, and in particular DNA methylation, as this has emerged as an attractive mechanistic link between aging and autoimmunity.

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Year:  2008        PMID： 18432411      PMCID： PMC3791432          DOI： 10.1080/08916930802024889

Source DB:  PubMed          Journal:  Autoimmunity        ISSN： 0891-6934            Impact factor:   2.815


  89 in total

1.  Effect of promoter methylation on the regulation of IFN-gamma gene during in vitro differentiation of human peripheral blood T cells into a Th2 population.

Authors:  Shingo Yano; Paritosh Ghosh; Hitoshi Kusaba; Meredith Buchholz; Dan L Longo
Journal:  J Immunol       Date:  2003-09-01       Impact factor: 5.422

2.  A developmental timing microRNA and its target regulate life span in C. elegans.

Authors:  Michelle Boehm; Frank Slack
Journal:  Science       Date:  2005-12-23       Impact factor: 47.728

Review 3.  Interleukin-6 in aging and chronic disease: a magnificent pathway.

Authors:  Marcello Maggio; Jack M Guralnik; Dan L Longo; Luigi Ferrucci
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2006-06       Impact factor: 6.053

4.  RhoB is epigenetically regulated in an age- and tissue-specific manner.

Authors:  Young Soo Yoon; Jung Ha Choo; Taekyung Yoo; Keunsoo Kang; Jae Hoon Chung
Journal:  Biochem Biophys Res Commun       Date:  2007-08-09       Impact factor: 3.575

5.  High accumulation of T regulatory cells prevents the activation of immune responses in aged animals.

Authors:  Sanjay Sharma; Ana Lucia Dominguez; Joseph Lustgarten
Journal:  J Immunol       Date:  2006-12-15       Impact factor: 5.422

6.  Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus.

Authors:  Robert A Waterland; Juan-Ru Lin; Charlotte A Smith; Randy L Jirtle
Journal:  Hum Mol Genet       Date:  2006-01-18       Impact factor: 6.150

Review 7.  Aging, cancer and nutrition: the DNA methylation connection.

Authors:  Liang Liu; Rebecca C Wylie; Lucy G Andrews; Trygve O Tollefsbol
Journal:  Mech Ageing Dev       Date:  2003-12       Impact factor: 5.432

Review 8.  DNA methylation and cancer.

Authors:  P W Laird; R Jaenisch
Journal:  Hum Mol Genet       Date:  1994       Impact factor: 6.150

Review 9.  microRNAs: small molecules with big roles - C. elegans to human cancer.

Authors:  Masaomi Kato; Frank J Slack
Journal:  Biol Cell       Date:  2008-02       Impact factor: 4.458

10.  Quantitative analysis of lymphocyte CD11a using standardized flow cytometry.

Authors:  M Pallis; A Robins; R Powell
Journal:  Scand J Immunol       Date:  1993-12       Impact factor: 3.487
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  33 in total

1.  miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation.

Authors:  Ruozhen Hu; Dominique A Kagele; Thomas B Huffaker; Marah C Runtsch; Margaret Alexander; Jin Liu; Erin Bake; Wei Su; Matthew A Williams; Dinesh S Rao; Thomas Möller; Gwenn A Garden; June L Round; Ryan M O'Connell
Journal:  Immunity       Date:  2014-10-16       Impact factor: 31.745

Review 2.  Epigenetic regulation in alcoholic liver disease.

Authors:  Pranoti Mandrekar
Journal:  World J Gastroenterol       Date:  2011-05-28       Impact factor: 5.742

Review 3.  Personalized medicine: understanding probabilities and managing expectations.

Authors:  Zachary Laksman; Allan S Detsky
Journal:  J Gen Intern Med       Date:  2010-09-28       Impact factor: 5.128

4.  Maternal micronutrient supplementation suppresses T cell chemokine receptor expression and function in F1 mice.

Authors:  Colin Delaney; Mark Hoeltzel; Sanjay K Garg; Roscoe Warner; Kent Johnson; Raymond Yung
Journal:  J Nutr       Date:  2012-05-30       Impact factor: 4.798

Review 5.  The ageing immune system: is it ever too old to become young again?

Authors:  Kenneth Dorshkind; Encarnacion Montecino-Rodriguez; Robert A J Signer
Journal:  Nat Rev Immunol       Date:  2009-01       Impact factor: 53.106

Review 6.  Strategies for reconstituting and boosting T cell-based immunity following haematopoietic stem cell transplantation: pre-clinical and clinical approaches.

Authors:  Ann P Chidgey; Natalie Seach; Jarrod Dudakov; Maree V Hammett; Richard L Boyd
Journal:  Semin Immunopathol       Date:  2008-11-04       Impact factor: 9.623

Review 7.  Epigenetics, aging, and autoimmunity.

Authors:  Raymond L Yung; Annabelle Julius
Journal:  Autoimmunity       Date:  2008-05       Impact factor: 2.815

Review 8.  Unresolved issues in theories of autoimmune disease using myocarditis as a framework.

Authors:  Robert Root-Bernstein; DeLisa Fairweather
Journal:  J Theor Biol       Date:  2014-12-04       Impact factor: 2.691

Review 9.  T cell replicative senescence in human aging.

Authors:  Jennifer P Chou; Rita B Effros
Journal:  Curr Pharm Des       Date:  2013       Impact factor: 3.116

10.  Activation of the immune response is a key feature of aging in mice.

Authors:  Thore C Brink; Christian Regenbrecht; Lloyd Demetrius; Hans Lehrach; James Adjaye
Journal:  Biogerontology       Date:  2009-12       Impact factor: 4.277
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