Literature DB >> 19104499

The ageing immune system: is it ever too old to become young again?

Kenneth Dorshkind1, Encarnacion Montecino-Rodriguez, Robert A J Signer.   

Abstract

Ageing is accompanied by a decline in the function of the immune system, which increases susceptibility to infections and can decrease the quality of life. The ability to rejuvenate the ageing immune system would therefore be beneficial for elderly individuals and would decrease health-care costs for society. But is the immune system ever too old to become young again? We review here the promise of various approaches to rejuvenate the function of the immune system in the rapidly growing ageing population.

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Year:  2009        PMID: 19104499     DOI: 10.1038/nri2471

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN: 1474-1733            Impact factor:   53.106


  60 in total

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Review 6.  Cancer and ageing: convergent and divergent mechanisms.

Authors:  Manuel Serrano; Maria A Blasco
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8.  Growth hormone enhances thymic function in HIV-1-infected adults.

Authors:  Laura A Napolitano; Diane Schmidt; Michael B Gotway; Niloufar Ameli; Erin L Filbert; Myra M Ng; Julie L Clor; Lorrie Epling; Elizabeth Sinclair; Paul D Baum; Kai Li; Marisela Lua Killian; Peter Bacchetti; Joseph M McCune
Journal:  J Clin Invest       Date:  2008-03       Impact factor: 14.808

Review 9.  Puzzles, promises and a cure for ageing.

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  159 in total

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Journal:  Immunity       Date:  2014-10-16       Impact factor: 31.745

Review 2.  Aging and immune function: molecular mechanisms to interventions.

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Journal:  Antioxid Redox Signal       Date:  2011-01-08       Impact factor: 8.401

Review 3.  Impact of aging on dendritic cell functions in humans.

Authors:  Anshu Agrawal; Sudhir Gupta
Journal:  Ageing Res Rev       Date:  2010-07-07       Impact factor: 10.895

4.  Trends in hospitalization rates and outcomes of endocarditis among Medicare beneficiaries.

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5.  Differential effects of aging and sex on stroke induced inflammation across the lifespan.

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Journal:  Exp Neurol       Date:  2013-08-29       Impact factor: 5.330

6.  Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing.

Authors:  Aysegul V Ergen; Nathan C Boles; Margaret A Goodell
Journal:  Blood       Date:  2012-01-30       Impact factor: 22.113

7.  Ageing and long-term CD4 cell count trends in HIV-positive patients with 5 years or more combination antiretroviral therapy experience.

Authors:  S T Wright; K Petoumenos; M Boyd; A Carr; S Downing; C C O'Connor; M Grotowski; M G Law
Journal:  HIV Med       Date:  2012-10-04       Impact factor: 3.180

8.  Identification of immunogenic MAGED4B peptides for vaccine development in oral cancer immunotherapy.

Authors:  Kue Peng Lim; Nicole Ai Leng Chun; Chai Phei Gan; Soo-Hwang Teo; Zainal Ariff Abdul Rahman; Mannil Thomas Abraham; Rosnah Binti Zain; Sathibalan Ponniah; Sok Ching Cheong
Journal:  Hum Vaccin Immunother       Date:  2014       Impact factor: 3.452

9.  Long term human reconstitution and immune aging in NOD-Rag (-)-γ chain (-) mice.

Authors:  David T Harris; Michael Badowski
Journal:  Immunobiology       Date:  2013-09-05       Impact factor: 3.144

Review 10.  Pro-inflammatory and anti-inflammatory T cells in giant cell arteritis.

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