Literature DB >> 18387785

To (TGF)beta or not to (TGF)beta: fine-tuning of Smad signaling via post-translational modifications.

Katharine H Wrighton1, Xin-Hua Feng.   

Abstract

Smad proteins are key signal transducers for the TGF-beta superfamily and are frequently inactivated in human cancers, yet the molecular basis of how their levels and activities are regulated remains unclear. Recent progress, discussed herein, illustrates the critical roles of Smad post-translational modifications in the cellular outcome to TGF-beta signaling.

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Year:  2008        PMID： 18387785      PMCID： PMC2597537          DOI： 10.1016/j.cellsig.2008.02.003

Source DB:  PubMed          Journal:  Cell Signal        ISSN： 0898-6568            Impact factor:   4.315


  125 in total

1.  Smad6 inhibits signalling by the TGF-beta superfamily.

Authors:  T Imamura; M Takase; A Nishihara; E Oeda; J Hanai; M Kawabata; K Miyazono
Journal:  Nature       Date:  1997-10-09       Impact factor: 49.962

2.  The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling.

Authors:  H Hayashi; S Abdollah; Y Qiu; J Cai; Y Y Xu; B W Grinnell; M A Richardson; J N Topper; M A Gimbrone; J L Wrana; D Falb
Journal:  Cell       Date:  1997-06-27       Impact factor: 41.582

3.  TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4.

Authors:  A Nakao; T Imamura; S Souchelnytskyi; M Kawabata; A Ishisaki; E Oeda; K Tamaki; J Hanai; C H Heldin; K Miyazono; P ten Dijke
Journal:  EMBO J       Date:  1997-09-01       Impact factor: 11.598

Review 4.  Non-Smad TGF-beta signals.

Authors:  Aristidis Moustakas; Carl-Henrik Heldin
Journal:  J Cell Sci       Date:  2005-08-15       Impact factor: 5.285

5.  TGF-beta and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions.

Authors:  Shigeo Mori; Koichi Matsuzaki; Katsunori Yoshida; Fukiko Furukawa; Yoshiya Tahashi; Hideo Yamagata; Go Sekimoto; Toshihito Seki; Hirofumi Matsui; Mikio Nishizawa; Jun-ichi Fujisawa; Kazuichi Okazaki
Journal:  Oncogene       Date:  2004-09-23       Impact factor: 9.867

6.  Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2.

Authors:  Min Liang; Yao-Yun Liang; Katharine Wrighton; Dana Ungermannova; Xiao-Ping Wang; F Charles Brunicardi; Xuedong Liu; Xin-Hua Feng; Xia Lin
Journal:  Mol Cell Biol       Date:  2004-09       Impact factor: 4.272

7.  Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation.

Authors:  Yongli Bai; Chun Yang; Kathrin Hu; Chris Elly; Yun-Cai Liu
Journal:  Mol Cell       Date:  2004-09-10       Impact factor: 17.970

8.  The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation.

Authors:  Su Ryeon Seo; François Lallemand; Nathalie Ferrand; Marcia Pessah; Sébastien L'Hoste; Jacques Camonis; Azeddine Atfi
Journal:  EMBO J       Date:  2004-09-09       Impact factor: 11.598

9.  Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).

Authors:  Akiyoshi Komuro; Takeshi Imamura; Masao Saitoh; Yoko Yoshida; Takao Yamori; Kohei Miyazono; Keiji Miyazawa
Journal:  Oncogene       Date:  2004-09-09       Impact factor: 9.867

10.  p21(WAF1/CIP1) at the switch between the anti-oncogenic and oncogenic faces of TGFbeta.

Authors:  Joan Seoane
Journal:  Cancer Biol Ther       Date:  2004-02-01       Impact factor: 4.742
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  22 in total

1.  Store-operated calcium entry suppressed the TGF-β1/Smad3 signaling pathway in glomerular mesangial cells.

Authors:  Sarika Chaudhari; Weizu Li; Yanxia Wang; Hui Jiang; Yuhong Ma; Mark E Davis; Jonathan E Zuckerman; Rong Ma
Journal:  Am J Physiol Renal Physiol       Date:  2017-06-21

2.  Transforming growth factor-β1 induces expression of human coagulation factor XII via Smad3 and JNK signaling pathways in human lung fibroblasts.

Authors:  Ewa Jablonska; Philipp Markart; Dariusz Zakrzewicz; Klaus T Preissner; Malgorzata Wygrecka
Journal:  J Biol Chem       Date:  2010-02-08       Impact factor: 5.157

3.  Regulation of Krüppel-like factor 4 by the anaphase promoting complex pathway is involved in TGF-beta signaling.

Authors:  Dong Hu; Yong Wan
Journal:  J Biol Chem       Date:  2010-12-22       Impact factor: 5.157

4.  TGF-β-activated kinase 1 (Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells.

Authors:  Kenji Yumoto; Penny S Thomas; Jamie Lane; Kouichi Matsuzaki; Maiko Inagaki; Jun Ninomiya-Tsuji; Gregory J Scott; Manas K Ray; Mamoru Ishii; Robert Maxson; Yuji Mishina; Vesa Kaartinen
Journal:  J Biol Chem       Date:  2013-04-01       Impact factor: 5.157

Review 5.  Posttranslational Regulation of Smads.

Authors:  Pinglong Xu; Xia Lin; Xin-Hua Feng
Journal:  Cold Spring Harb Perspect Biol       Date:  2016-12-01       Impact factor: 10.005

6.  Murine protein serine/threonine kinase 38 stimulates TGF-beta signaling in a kinase-dependent manner via direct phosphorylation of Smad proteins.

Authors:  Hyun-A Seong; Haiyoung Jung; Hyunjung Ha
Journal:  J Biol Chem       Date:  2010-07-21       Impact factor: 5.157

Review 7.  Regulation of TGF-beta signalling by protein phosphatases.

Authors:  Ting Liu; Xin-Hua Feng
Journal:  Biochem J       Date:  2010-09-01       Impact factor: 3.857

8.  Expression of USP15, TβR-I and Smad7 in psoriasis.

Authors:  Ai-Ping Feng; Yi-Min He; Xin-Xin Liu; Jia-Wen Li; Ya-Ting Tu; Feng Hu; Shan-Juan Chen
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2014-06-18

9.  Transforming growth factor-(beta)s and mammary gland involution; functional roles and implications for cancer progression.

Authors:  Kathleen C Flanders; Lalage M Wakefield
Journal:  J Mammary Gland Biol Neoplasia       Date:  2009-04-25       Impact factor: 2.673

10.  OSR1 phosphorylates the Smad2/3 linker region and induces TGF-β1 autocrine to promote EMT and metastasis in breast cancer.

Authors:  Yang Li; Lei Li; Jun Qin; Junyi Wu; Xueming Dai; Junming Xu
Journal:  Oncogene       Date:  2020-10-13       Impact factor: 9.867
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