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Literature DB >> 19396528

Transforming growth factor-(beta)s and mammary gland involution; functional roles and implications for cancer progression.

Kathleen C Flanders¹, Lalage M Wakefield.

Abstract

During rodent mammary gland involution there is a dramatic increase in the expression of the transforming growth factor-beta isoform, TGF-beta3. The TGF-betas are multifunctional cytokines which play important roles in wound healing and in carcinogenesis. The responses that are activated in the remodeling of the gland during involution have many similarities with the wound healing process and have been postulated to generate a mammary stroma that provides a microenvironment favoring tumor progression. In this review we will discuss the putative role of TGF-beta during involution, as well as its effects on the mammary microenvironment and possible implications for pregnancy-associated tumorigenesis.

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Year: 2009 PMID： 19396528 PMCID： PMC2797127 DOI： 10.1007/s10911-009-9122-z

Source DB: PubMed Journal: J Mammary Gland Biol Neoplasia ISSN： 1083-3021 Impact factor: 2.673

133 in total

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Journal: Cytokine Growth Factor Rev Date: 2005-01-25 Impact factor: 7.638

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Journal: Mol Reprod Dev Date: 1992-06 Impact factor: 2.609

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Journal: J Cell Physiol Date: 2009-04 Impact factor: 6.384

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Journal: Development Date: 1991-06 Impact factor: 6.868

41 in total

Review 1. microRNAs and EMT in mammary cells and breast cancer.

Authors: Josephine A Wright; Jennifer K Richer; Gregory J Goodall
Journal: J Mammary Gland Biol Neoplasia Date: 2010-05-25 Impact factor: 2.673

2. Transforming growth factor-β1 29T>C genetic polymorphism is associated with lymph node metastasis in patients with adenocarcinoma of the lung.

Authors: Yoshihiro Minamiya; Masatomo Miura; Yudai Hinai; Hajime Saito; Manabu Ito; Takashi Ono; Hiroshi Toda; Satoru Motoyama; Jun-ichi Ogawa
Journal: Tumour Biol Date: 2010-05-27

3. Histology and Transcriptome Profiles of the Mammary Gland across Critical Windows of Development in Sprague Dawley Rats.

Authors: Kalpana Gopalakrishnan; Susan L Teitelbaum; James Wetmur; Fabiana Manservisi; Laura Falcioni; Simona Panzacchi; Federica Gnudi; Fiorella Belpoggi; Jia Chen
Journal: J Mammary Gland Biol Neoplasia Date: 2018-06-28 Impact factor: 2.673

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Authors: Karen A Dunphy; Alan L Schneyer; Mary J Hagen; D Joseph Jerry
Journal: J Mammary Gland Biol Neoplasia Date: 2011-04-08 Impact factor: 2.673

5. Regulation of epithelial to mesenchymal transition: CK2β on stage.

Authors: Alexandre Deshiere; Eve Duchemin-Pelletier; Elodie Spreux; Delphine Ciais; Christelle Forcet; Claude Cochet; Odile Filhol
Journal: Mol Cell Biochem Date: 2011-07-14 Impact factor: 3.396

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Authors: Jamie C Stanford; Christian Young; Donna Hicks; Philip Owens; Andrew Williams; David B Vaught; Meghan M Morrison; Jiyeon Lim; Michelle Williams; Dana M Brantley-Sieders; Justin M Balko; Debra Tonetti; H Shelton Earp; Rebecca S Cook
Journal: J Clin Invest Date: 2014-09-24 Impact factor: 14.808

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Authors: Paola Piantoni; Ping Wang; James K Drackley; Walter L Hurley; Juan J Loor
Journal: Bioinform Biol Insights Date: 2010-09-20