Literature DB >> 20704570

Regulation of TGF-beta signalling by protein phosphatases.

Ting Liu1, Xin-Hua Feng.   

Abstract

Tight regulation of TGF-beta (transforming growth factor-beta) superfamily signalling is important for normal cellular functions and tissue homoeostasis. Since TGF-beta superfamily signalling pathways are activated by a short phosphorylation cascade, from receptor phosphorylation to subsequent phosphorylation and activation of downstream signal transducer R-Smads (receptor-activated Smads), reversible phosphorylation serves as a critical step to assure proper TGF-beta signalling. The present article will review the current progress on the understanding of dynamic phosphorylation in TGF-beta signalling and the essential role of protein phosphatases in this process.

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Year:  2010        PMID： 20704570      PMCID： PMC3154754          DOI： 10.1042/BJ20100427

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  95 in total

1.  Protein serine/threonine phosphatase PPM1A dephosphorylates Smad1 in the bone morphogenetic protein signaling pathway.

Authors:  Xueyan Duan; Yao-Yun Liang; Xin-Hua Feng; Xia Lin
Journal:  J Biol Chem       Date:  2006-08-24       Impact factor: 5.157

Review 2.  Negative regulation of TGF-beta receptor/Smad signal transduction.

Authors:  Susumu Itoh; Peter ten Dijke
Journal:  Curr Opin Cell Biol       Date:  2007-02-20       Impact factor: 8.382

3.  Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal.

Authors:  Luis C Fuentealba; Edward Eivers; Atsushi Ikeda; Cecilia Hurtado; Hiroki Kuroda; Edgar M Pera; Edward M De Robertis
Journal:  Cell       Date:  2007-11-30       Impact factor: 41.582

Review 4.  Termination of TGF-beta superfamily signaling through SMAD dephosphorylation--a functional genomic view.

Authors:  Xia Lin; Yeguang Chen; Anming Meng; Xinhua Feng
Journal:  J Genet Genomics       Date:  2007-01       Impact factor: 4.275

5.  Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling.

Authors:  Marie Knockaert; Gopal Sapkota; Claudio Alarcón; Joan Massagué; Ali H Brivanlou
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-01       Impact factor: 11.205

6.  Small C-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance transforming growth factor-beta signaling.

Authors:  Katharine H Wrighton; Danielle Willis; Jianyin Long; Fang Liu; Xia Lin; Xin-Hua Feng
Journal:  J Biol Chem       Date:  2006-10-10       Impact factor: 5.157

7.  Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways.

Authors:  Gopal Sapkota; Marie Knockaert; Claudio Alarcón; Ermelinda Montalvo; Ali H Brivanlou; Joan Massagué
Journal:  J Biol Chem       Date:  2006-11-02       Impact factor: 5.157

8.  Balancing BMP signaling through integrated inputs into the Smad1 linker.

Authors:  Gopal Sapkota; Claudio Alarcón; Francesca M Spagnoli; Ali H Brivanlou; Joan Massagué
Journal:  Mol Cell       Date:  2007-02-09       Impact factor: 17.970

Review 9.  TGF-beta signaling: a tale of two responses.

Authors:  Rod A Rahimi; Edward B Leof
Journal:  J Cell Biochem       Date:  2007-10-15       Impact factor: 4.429

10.  Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion.

Authors:  Amy J Galliher; William P Schiemann
Journal:  Cancer Res       Date:  2007-04-15       Impact factor: 12.701
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  36 in total

1.  Store-operated calcium entry suppressed the TGF-β1/Smad3 signaling pathway in glomerular mesangial cells.

Authors:  Sarika Chaudhari; Weizu Li; Yanxia Wang; Hui Jiang; Yuhong Ma; Mark E Davis; Jonathan E Zuckerman; Rong Ma
Journal:  Am J Physiol Renal Physiol       Date:  2017-06-21

Review 2.  Structural determinants of Smad function in TGF-β signaling.

Authors:  Maria J Macias; Pau Martin-Malpartida; Joan Massagué
Journal:  Trends Biochem Sci       Date:  2015-04-29       Impact factor: 13.807

3.  Averting a roadblock in transforming growth factor β signaling.

Authors:  Lan Xu
Journal:  Mol Cell Biol       Date:  2011-08-08       Impact factor: 4.272

4.  Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling.

Authors:  Xiwu Chen; Hongtao Wang; Hong-Jun Liao; Wen Hu; Leslie Gewin; Glenda Mernaugh; Sheng Zhang; Zhong-Yin Zhang; Lorenzo Vega-Montoto; Roberto M Vanacore; Reinhard Fässler; Roy Zent; Ambra Pozzi
Journal:  J Clin Invest       Date:  2014-07-01       Impact factor: 14.808

Review 5.  Paradoxical roles of TGF-β signaling in suppressing and promoting squamous cell carcinoma.

Authors:  Fanglong Wu; Kelsey J Weigel; Hongmei Zhou; Xiao-Jing Wang
Journal:  Acta Biochim Biophys Sin (Shanghai)       Date:  2018-01-01       Impact factor: 3.848

Review 6.  The Genetic Basis of Peyronie Disease: A Review.

Authors:  Amin S Herati; Alexander W Pastuszak
Journal:  Sex Med Rev       Date:  2016-01-08

7.  p21-Activated kinase 2 (PAK2) inhibits TGF-β signaling in Madin-Darby canine kidney (MDCK) epithelial cells by interfering with the receptor-Smad interaction.

Authors:  Xiaohua Yan; Junyu Zhang; Qinyu Sun; Polygena T Tuazon; Xiaoping Wu; Jolinda A Traugh; Ye-Guang Chen
Journal:  J Biol Chem       Date:  2012-03-05       Impact factor: 5.157

8.  Identification and expression of Smads associated with TGF-β/activin/nodal signaling pathways in the rainbow trout (Oncorhynchus mykiss).

Authors:  Scott A Gahr; Gregory M Weber; Caird E Rexroad
Journal:  Fish Physiol Biochem       Date:  2012-10       Impact factor: 2.794

Review 9.  Modulators of erythropoiesis: emerging therapies for hemoglobinopathies and disorders of red cell production.

Authors:  Laura Breda; Stefano Rivella
Journal:  Hematol Oncol Clin North Am       Date:  2014-01-18       Impact factor: 3.722

10.  Hyaluronan esters drive Smad gene expression and signaling enhancing cardiogenesis in mouse embryonic and human mesenchymal stem cells.

Authors:  Margherita Maioli; Sara Santaniello; Andrea Montella; Pasquale Bandiera; Silvia Cantoni; Claudia Cavallini; Francesca Bianchi; Vincenzo Lionetti; Flavio Rizzolio; Irene Marchesi; Luigi Bagella; Carlo Ventura
Journal:  PLoS One       Date:  2010-11-30       Impact factor: 3.240
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