OBJECTIVE: To compare the metabolic effects of fructose in healthy male and female subjects. RESEARCH DESIGN AND METHODS: Fasting metabolic profile and hepatic insulin sensitivity were assessed by means of a hyperglycemic clamp in 16 healthy young male and female subjects after a 6-day fructose overfeeding. RESULTS: Fructose overfeeding increased fasting triglyceride concentrations by 71 vs. 16% in male vs. female subjects, respectively (P < 0.05). Endogenous glucose production was increased by 12%, alanine aminotransferase concentration was increased by 38%, and fasting insulin concentrations were increased by 14% after fructose overfeeding in male subjects (all P < 0.05) but were not significantly altered in female subjects. Fasting plasma free fatty acids and lipid oxidation were inhibited by fructose in male but not in female subjects. CONCLUSIONS: Short-term fructose overfeeding produces hypertriglyceridemia and hepatic insulin resistance in men, but these effects are markedly blunted in healthy young women.
OBJECTIVE: To compare the metabolic effects of fructose in healthy male and female subjects. RESEARCH DESIGN AND METHODS: Fasting metabolic profile and hepatic insulin sensitivity were assessed by means of a hyperglycemic clamp in 16 healthy young male and female subjects after a 6-day fructose overfeeding. RESULTS:Fructose overfeeding increased fasting triglyceride concentrations by 71 vs. 16% in male vs. female subjects, respectively (P < 0.05). Endogenous glucose production was increased by 12%, alanine aminotransferase concentration was increased by 38%, and fasting insulin concentrations were increased by 14% after fructose overfeeding in male subjects (all P < 0.05) but were not significantly altered in female subjects. Fasting plasma freefatty acids and lipid oxidation were inhibited by fructose in male but not in female subjects. CONCLUSIONS: Short-term fructose overfeeding produces hypertriglyceridemia and hepatic insulin resistance in men, but these effects are markedly blunted in healthy young women.
Authors: Carlos A Roncal-Jimenez; Miguel A Lanaspa; Christopher J Rivard; Takahiko Nakagawa; L Gabriela Sanchez-Lozada; Diana Jalal; Ana Andres-Hernando; Katsuyuki Tanabe; Magdalena Madero; Nanxing Li; Christina Cicerchi; Kim Mc Fann; Yuri Y Sautin; Richard J Johnson Journal: Metabolism Date: 2011-04-12 Impact factor: 8.694
Authors: D'Angelo C Magliano; Aline Penna-de-Carvalho; Manuel Vazquez-Carrera; Carlos A Mandarim-de-Lacerda; Marcia B Aguila Journal: Endocrine Date: 2015-04-09 Impact factor: 3.633
Authors: John L Sievenpiper; Amanda J Carleton; Sheena Chatha; Henry Y Jiang; Russell J de Souza; Joseph Beyene; Cyril W C Kendall; David J A Jenkins Journal: Diabetes Care Date: 2009-07-10 Impact factor: 17.152
Authors: Kimber L Stanhope; Jean Marc Schwarz; Nancy L Keim; Steven C Griffen; Andrew A Bremer; James L Graham; Bonnie Hatcher; Chad L Cox; Artem Dyachenko; Wei Zhang; John P McGahan; Anthony Seibert; Ronald M Krauss; Sally Chiu; Ernst J Schaefer; Masumi Ai; Seiko Otokozawa; Katsuyuki Nakajima; Takamitsu Nakano; Carine Beysen; Marc K Hellerstein; Lars Berglund; Peter J Havel Journal: J Clin Invest Date: 2009-04-20 Impact factor: 14.808