Literature DB >> 18299834

Immunopathological aspects of age-related macular degeneration.

Mrinali Patel1, Chi-Chao Chan.   

Abstract

Age-related macular degeneration (AMD) represents a leading cause of blindness worldwide. While the clinical and histopathological aspects of AMD are well characterized, its etiology and pathogenesis remain unclear. Recent findings suggest a role for immunologic processes in AMD pathogenesis, including the age-related generation of extracellular deposits inside the Brusch membrane and beneath the retinal pigment epithelium, recruitment of macrophages for clearance of these deposits, complement activation, recruitment of tissue-destructive macrophages, microglial activation and accumulation, and proinflammatory effects of chronic inflammation by Chlamydia pneumoniae. This review discusses the evidence for the role of inflammation in human AMD and in animal models of AMD.

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Year:  2008        PMID： 18299834      PMCID： PMC2441602          DOI： 10.1007/s00281-008-0112-9

Source DB:  PubMed          Journal:  Semin Immunopathol        ISSN： 1863-2297            Impact factor:   9.623


  95 in total

1.  A potential role for immune complex pathogenesis in drusen formation.

Authors:  L V Johnson; S Ozaki; M K Staples; P A Erickson; D H Anderson
Journal:  Exp Eye Res       Date:  2000-04       Impact factor: 3.467

2.  The LOC387715 polymorphism and age-related macular degeneration: replication in three case-control samples.

Authors:  Robert J Ross; Christine M Bojanowski; Jie Jin Wang; Emily Y Chew; Elena Rochtchina; Frederick L Ferris; Paul Mitchell; Chi-Chao Chan; Jingsheng Tuo
Journal:  Invest Ophthalmol Vis Sci       Date:  2007-03       Impact factor: 4.799

3.  Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease.

Authors:  R F Mullins; S R Russell; D H Anderson; G S Hageman
Journal:  FASEB J       Date:  2000-05       Impact factor: 5.191

4.  Inhibition of laser-induced choroidal neovascularization by atorvastatin by downregulation of monocyte chemotactic protein-1 synthesis in mice.

Authors:  Kiyoshi Yamada; Eiji Sakurai; Masahiro Itaya; Satoshi Yamasaki; Yuichiro Ogura
Journal:  Invest Ophthalmol Vis Sci       Date:  2007-04       Impact factor: 4.799

5.  Scavenger receptors for oxidized lipoprotein in age-related macular degeneration.

Authors:  Motohiro Kamei; Kazuhito Yoneda; Noriaki Kume; Mihoko Suzuki; Hiroyuki Itabe; Ken-Ichi Matsuda; Takeshi Shimaoka; Manabu Minami; Shin Yonehara; Toru Kita; Shigeru Kinoshita
Journal:  Invest Ophthalmol Vis Sci       Date:  2007-04       Impact factor: 4.799

6.  Y402H polymorphism of complement factor H affects binding affinity to C-reactive protein.

Authors:  Matti Laine; Hanna Jarva; Sanna Seitsonen; Karita Haapasalo; Markus J Lehtinen; Nina Lindeman; Don H Anderson; Patrick T Johnson; Irma Järvelä; T Sakari Jokiranta; Gregory S Hageman; Ilkka Immonen; Seppo Meri
Journal:  J Immunol       Date:  2007-03-15       Impact factor: 5.422

7.  Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments.

Authors:  Mei Chen; John V Forrester; Heping Xu
Journal:  Exp Eye Res       Date:  2006-12-31       Impact factor: 3.467

Review 8.  The role of oxidative stress in the pathogenesis of age-related macular degeneration.

Authors:  S Beatty; H Koh; M Phil; D Henson; M Boulton
Journal:  Surv Ophthalmol       Date:  2000 Sep-Oct       Impact factor: 6.048

9.  CD59, a complement regulatory protein, controls choroidal neovascularization in a mouse model of wet-type age-related macular degeneration.

Authors:  Nalini S Bora; Sankaranarayanan Kaliappan; Purushottam Jha; Qin Xu; Baalasubramanian Sivasankar; Claire L Harris; B Paul Morgan; Puran S Bora
Journal:  J Immunol       Date:  2007-02-01       Impact factor: 5.422

Review 10.  An update on the genetics of age-related macular degeneration.

Authors:  Hendrik P N Scholl; Monika Fleckenstein; Peter Charbel Issa; Claudia Keilhauer; Frank G Holz; Bernhard H F Weber
Journal:  Mol Vis       Date:  2007-02-07       Impact factor: 2.367
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  77 in total

1.  Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells.

Authors:  Qingning Bian; Shasha Gao; Jilin Zhou; Jian Qin; Allen Taylor; Elizabeth J Johnson; Guangwen Tang; Janet R Sparrow; Dennis Gierhart; Fu Shang
Journal:  Free Radic Biol Med       Date:  2012-06-23       Impact factor: 7.376

2.  Treatment of dry age-related macular degeneration with dobesilate.

Authors:  P Cuevas; L A Outeiriño; J Angulo; G Giménez-Gallego
Journal:  BMJ Case Rep       Date:  2012-06-21

Review 3.  A Brief Discussion on Lipid Activated Nuclear Receptors and their Potential Role in Regulating Microglia in Age-Related Macular Degeneration (AMD).

Authors:  Mayur Choudhary; Goldis Malek
Journal:  Adv Exp Med Biol       Date:  2016       Impact factor: 2.622

Review 4.  Complement pathway biomarkers and age-related macular degeneration.

Authors:  M Gemenetzi; A J Lotery
Journal:  Eye (Lond)       Date:  2015-10-23       Impact factor: 3.775

5.  The role of anti-inflammatory agents in age-related macular degeneration (AMD) treatment.

Authors:  Y Wang; V M Wang; C-C Chan
Journal:  Eye (Lond)       Date:  2010-12-24       Impact factor: 3.775

Review 6.  Molecular pathology of age-related macular degeneration.

Authors:  Xiaoyan Ding; Mrinali Patel; Chi-Chao Chan
Journal:  Prog Retin Eye Res       Date:  2008-11-06       Impact factor: 21.198

7.  Choroidal γδ T cells in protection against retinal pigment epithelium and retinal injury.

Authors:  Zhenyang Zhao; Yuejin Liang; Yin Liu; Pei Xu; Miles J Flamme-Wiese; Deming Sun; Jiaren Sun; Robert F Mullins; Yan Chen; Jiyang Cai
Journal:  FASEB J       Date:  2017-07-20       Impact factor: 5.191

8.  Cholesterol crystals induce inflammatory cytokines expression in a human retinal pigment epithelium cell line by activating the NF-κB pathway.

Authors:  Yijun Hu; Haijiang Lin; Bernard Dib; Alp Atik; Peggy Bouzika; Christopher Lin; Yueran Yan; Shibo Tang; Joan W Miller; Demetrios G Vavvas
Journal:  Discov Med       Date:  2014 Jul-Aug       Impact factor: 2.970

9.  Chlamydia pneumoniae infection, complement factor H variants and age-related macular degeneration.

Authors:  D Shen; J Tuo; M Patel; A A Herzlich; X Ding; E Y Chew; C-C Chan
Journal:  Br J Ophthalmol       Date:  2008-11-07       Impact factor: 4.638

10.  A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration.

Authors:  Jingsheng Tuo; Robert J Ross; Alexandra A Herzlich; Defen Shen; Xiaoyan Ding; Min Zhou; Steven L Coon; Nahed Hussein; Norman Salem; Chi-Chao Chan
Journal:  Am J Pathol       Date:  2009-07-16       Impact factor: 4.307
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