Literature DB >> 26493033

Complement pathway biomarkers and age-related macular degeneration.

M Gemenetzi1, A J Lotery2,3.   

Abstract

In the age-related macular degeneration (AMD) 'inflammation model', local inflammation plus complement activation contributes to the pathogenesis and progression of the disease. Multiple genetic associations have now been established correlating the risk of development or progression of AMD. Stratifying patients by their AMD genetic profile may facilitate future AMD therapeutic trials resulting in meaningful clinical trial end points with smaller sample sizes and study duration.

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Year:  2015        PMID： 26493033      PMCID： PMC4709545          DOI： 10.1038/eye.2015.203

Source DB:  PubMed          Journal:  Eye (Lond)        ISSN： 0950-222X            Impact factor:   3.775


  125 in total

1.  The LOC387715 polymorphism and age-related macular degeneration: replication in three case-control samples.

Authors:  Robert J Ross; Christine M Bojanowski; Jie Jin Wang; Emily Y Chew; Elena Rochtchina; Frederick L Ferris; Paul Mitchell; Chi-Chao Chan; Jingsheng Tuo
Journal:  Invest Ophthalmol Vis Sci       Date:  2007-03       Impact factor: 4.799

2.  Short-term safety and efficacy of intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration.

Authors:  Ryan M Rich; Philip J Rosenfeld; Carmen A Puliafito; Sander R Dubovy; Janet L Davis; Harry W Flynn; Serafin Gonzalez; William J Feuer; Richard C Lin; Geeta A Lalwani; Jackie K Nguyen; Gaurav Kumar
Journal:  Retina       Date:  2006 May-Jun       Impact factor: 4.256

3.  Complement factor H variant increases the risk of age-related macular degeneration.

Authors:  Jonathan L Haines; Michael A Hauser; Silke Schmidt; William K Scott; Lana M Olson; Paul Gallins; Kylee L Spencer; Shu Ying Kwan; Maher Noureddine; John R Gilbert; Nathalie Schnetz-Boutaud; Anita Agarwal; Eric A Postel; Margaret A Pericak-Vance
Journal:  Science       Date:  2005-03-10       Impact factor: 47.728

4.  Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent.

Authors:  Bin Bao; Ananda S Prasad; Frances W J Beck; James T Fitzgerald; Diane Snell; Ginny W Bao; Tapinder Singh; Lavoisier J Cardozo
Journal:  Am J Clin Nutr       Date:  2010-04-28       Impact factor: 7.045

5.  CFH, VEGF and HTRA1 promoter genotype may influence the response to intravitreal ranibizumab therapy for neovascular age-related macular degeneration.

Authors:  Martin McKibbin; Manir Ali; Shveta Bansal; Paul D Baxter; Kumi West; Grange Williams; Frances Cassidy; Chris F Inglehearn
Journal:  Br J Ophthalmol       Date:  2011-05-10       Impact factor: 4.638

6.  Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.

Authors:  Sarah Ennis; Catherine Jomary; Robert Mullins; Angela Cree; Xiaoli Chen; Alex Macleod; Stephen Jones; Andrew Collins; Edwin Stone; Andrew Lotery
Journal:  Lancet       Date:  2008-10-06       Impact factor: 79.321

7.  The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration.

Authors:  Lincoln V Johnson; William P Leitner; Alexander J Rivest; Michelle K Staples; Monte J Radeke; Don H Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-20       Impact factor: 11.205

8.  Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial.

Authors: 
Journal:  JAMA       Date:  2013-05-15       Impact factor: 56.272

9.  Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to intravitreal bevacizumab.

Authors:  Milam A Brantley; Amy M Fang; Jennifer M King; Asheesh Tewari; Steven M Kymes; Alan Shiels
Journal:  Ophthalmology       Date:  2007-12       Impact factor: 12.079

10.  His-384 allotypic variant of factor H associated with age-related macular degeneration has different heparin binding properties from the non-disease-associated form.

Authors:  Simon J Clark; Victoria A Higman; Barbara Mulloy; Stephen J Perkins; Susan M Lea; Robert B Sim; Anthony J Day
Journal:  J Biol Chem       Date:  2006-06-20       Impact factor: 5.157
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  18 in total

Review 1.  From compliment to insult: genetics of the complement system in physiology and disease in the human retina.

Authors:  Robert F Mullins; Alasdair N Warwick; Elliott H Sohn; Andrew J Lotery
Journal:  Hum Mol Genet       Date:  2017-08-01       Impact factor: 6.150

2.  Fluorescent silver nanoclusters as antibody label in a competitive immunoassay for the complement factor H.

Authors:  Eva Valencia; María Cruz-Alonso; Lydia Álvarez; Héctor González-Iglesias; Beatriz Fernández; Rosario Pereiro
Journal:  Mikrochim Acta       Date:  2019-06-11       Impact factor: 5.833

Review 3.  Modern Therapeutic Approaches for Noninfectious Ocular Diseases Involving Inflammation.

Authors:  Michelle L Ratay; Elena Bellotti; Riccardo Gottardi; Steven R Little
Journal:  Adv Healthc Mater       Date:  2017-10-16       Impact factor: 9.933

Review 4.  Can innate and autoimmune reactivity forecast early and advance stages of age-related macular degeneration?

Authors:  Grazyna Adamus
Journal:  Autoimmun Rev       Date:  2017-01-28       Impact factor: 9.754

5.  Correlation of neutrophil/lymphocyte and platelet/lymphocyte ratio with visual acuity and macular thickness in age-related macular degeneration.

Authors:  Elvan Alper Sengul; Ozgur Artunay; Alev Kockar; Ceyda Afacan; Rifat Rasier; Palmet Gun; Nazli Gul Yalcin; Erdal Yuzbasioglu
Journal:  Int J Ophthalmol       Date:  2017-05-18       Impact factor: 1.779

6.  Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids.

Authors:  Sonali Nashine; Marilyn Chwa; Mina Kazemian; Kunal Thaker; Stephanie Lu; Anthony Nesburn; Baruch D Kuppermann; M Cristina Kenney
Journal:  PLoS One       Date:  2016-08-03       Impact factor: 3.240

Review 7.  Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors.

Authors:  Katie L Pennington; Margaret M DeAngelis
Journal:  Eye Vis (Lond)       Date:  2016-12-22

8.  Age-Related Macular Degeneration: A Connection between Human Herpes Virus-6A-Induced CD46 Downregulation and Complement Activation?

Authors:  Walter Fierz
Journal:  Front Immunol       Date:  2017-10-17       Impact factor: 7.561

9.  Insensitivity of PI3K/Akt/GSK3 signaling in peripheral blood mononuclear cells of age-related macular degeneration patients.

Authors:  Xunxian Liu; Zemin Yao
Journal:  J Biomed Res       Date:  2017-01-19

10.  Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress.

Authors:  Giorgia Fanelli; Anai Gonzalez-Cordero; Peter J Gardner; Qi Peng; Milan Fernando; Magdalena Kloc; Conrad A Farrar; Arifa Naeem; Peter Garred; Robin R Ali; Steven H Sacks
Journal:  Sci Rep       Date:  2017-11-07       Impact factor: 4.379
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