Literature DB >> 1825351

The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A.

J M Ruppert1, B Vogelstein, K W Kinzler.   

Abstract

The GLI gene was previously isolated by virtue of its amplification in human glioblastomas. We have now found that GLI expression can result in the in vitro transformation of both primary and secondary rodent cells. When coexpressed with adenovirus E1A, the GLI protein functions analogously to RAS, resulting in the formation of dense foci of cells which are tumorigenic in nude mice.

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Year:  1991        PMID： 1825351      PMCID： PMC369482          DOI： 10.1128/mcb.11.3.1724-1728.1991

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  36 in total

1.  The GLI gene encodes a nuclear protein which binds specific sequences in the human genome.

Authors:  K W Kinzler; B Vogelstein
Journal:  Mol Cell Biol       Date:  1990-02       Impact factor: 4.272

2.  Factors affecting the frequency of transformation of rat embryo cells by simian virus 40.

Authors:  R Risser; R Pollack
Journal:  Virology       Date:  1979-01-15       Impact factor: 3.616

3.  GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity.

Authors:  J M Ruppert; B Vogelstein; K Arheden; K W Kinzler
Journal:  Mol Cell Biol       Date:  1990-10       Impact factor: 4.272

Review 4.  Gene amplification in cultured animal cells.

Authors:  R T Schimke
Journal:  Cell       Date:  1984-07       Impact factor: 41.582

5.  Malignant transformation of early passage rodent cells by a single mutated human oncogene.

Authors:  D A Spandidos; N M Wilkie
Journal:  Nature       Date:  1984 Aug 9-15       Impact factor: 49.962

6.  Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture.

Authors:  H E Ruley
Journal:  Nature       Date:  1983 Aug 18-24       Impact factor: 49.962

7.  Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA.

Authors:  A Houweling; P J van den Elsen; A J van der Eb
Journal:  Virology       Date:  1980-09       Impact factor: 3.616

8.  Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila.

Authors:  T V Orenic; D C Slusarski; K L Kroll; R A Holmgren
Journal:  Genes Dev       Date:  1990-06       Impact factor: 11.361

9.  Identification of an amplified, highly expressed gene in a human glioma.

Authors:  K W Kinzler; S H Bigner; D D Bigner; J M Trent; M L Law; S J O'Brien; A J Wong; B Vogelstein
Journal:  Science       Date:  1987-04-03       Impact factor: 47.728

10.  Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes.

Authors:  J Miller; A D McLachlan; A Klug
Journal:  EMBO J       Date:  1985-06       Impact factor: 11.598
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  36 in total

Review 1.  The sonic hedgehog-patched-gli pathway in human development and disease.

Authors:  E H Villavicencio; D O Walterhouse; P M Iannaccone
Journal:  Am J Hum Genet       Date:  2000-09-21       Impact factor: 11.025

2.  A KLF4-miRNA-206 autoregulatory feedback loop can promote or inhibit protein translation depending upon cell context.

Authors:  Chen-Chung Lin; Ling-Zhi Liu; Joseph B Addison; William F Wonderlin; Alexey V Ivanov; J Michael Ruppert
Journal:  Mol Cell Biol       Date:  2011-04-25       Impact factor: 4.272

3.  A dominant mutation in the Wilms tumor gene WT1 cooperates with the viral oncogene E1A in transformation of primary kidney cells.

Authors:  D A Haber; H T Timmers; J Pelletier; P A Sharp; D E Housman
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-01       Impact factor: 11.205

Review 4.  Molecular genetics of neurological tumours.

Authors:  R Y Chung; B R Seizinger
Journal:  J Med Genet       Date:  1992-06       Impact factor: 6.318

5.  Conservation of the C.elegans tra-2 3'UTR translational control.

Authors:  E Jan; J W Yoon; D Walterhouse; P Iannaccone; E B Goodwin
Journal:  EMBO J       Date:  1997-10-15       Impact factor: 11.598

6.  Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors.

Authors:  Dennis Liang Fei; Hua Li; Courtney D Kozul; Kendall E Black; Samer Singh; Julie A Gosse; James DiRenzo; Kathleen A Martin; Baolin Wang; Joshua W Hamilton; Margaret R Karagas; David J Robbins
Journal:  Cancer Res       Date:  2010-02-23       Impact factor: 12.701

7.  Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation.

Authors:  X Li; W Deng; C D Nail; S K Bailey; M H Kraus; J M Ruppert; S M Lobo-Ruppert
Journal:  Oncogene       Date:  2006-01-26       Impact factor: 9.867

8.  Gli1 promotes cell survival and is predictive of a poor outcome in ERalpha-negative breast cancer.

Authors:  Lusheng Xu; Yeon-Jin Kwon; Natalya Frolova; Adam D Steg; Kun Yuan; Martin R Johnson; William E Grizzle; Renee A Desmond; Andra R Frost
Journal:  Breast Cancer Res Treat       Date:  2009-11-10       Impact factor: 4.872

9.  Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation.

Authors:  Gianluca Canettieri; Lucia Di Marcotullio; Azzura Greco; Sonia Coni; Laura Antonucci; Paola Infante; Laura Pietrosanti; Enrico De Smaele; Elisabetta Ferretti; Evelina Miele; Marianna Pelloni; Giuseppina De Simone; Emilia Maria Pedone; Paola Gallinari; Alessandra Giorgi; Christian Steinkühler; Luigi Vitagliano; Carlo Pedone; M Eugenià Schinin; Isabella Screpanti; Alberto Gulino
Journal:  Nat Cell Biol       Date:  2010-01-17       Impact factor: 28.824

10.  p53 modulates the activity of the GLI1 oncogene through interactions with the shared coactivator TAF9.

Authors:  Joon Won Yoon; Marilyn Lamm; Stephen Iannaccone; Nicole Higashiyama; King Fu Leong; Philip Iannaccone; David Walterhouse
Journal:  DNA Repair (Amst)       Date:  2015-08-01
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