Literature DB >> 3563490

Identification of an amplified, highly expressed gene in a human glioma.

K W Kinzler, S H Bigner, D D Bigner, J M Trent, M L Law, S J O'Brien, A J Wong, B Vogelstein.   

Abstract

A gene, termed gli, was identified that is amplified more than 50-fold in a malignant glioma. The gene is expressed at high levels in the original tumor and its derived cell line and is located at chromosome 12 position (q13 to q14.3). The gli gene is a member of a select group of cellular genes that are genetically altered in primary human tumors.

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Year:  1987        PMID： 3563490     DOI： 10.1126/science.3563490

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  200 in total

Review 1.  The sonic hedgehog-patched-gli pathway in human development and disease.

Authors:  E H Villavicencio; D O Walterhouse; P M Iannaccone
Journal:  Am J Hum Genet       Date:  2000-09-21       Impact factor: 11.025

Review 2.  Potential therapeutic implications of cancer stem cells in glioblastoma.

Authors:  Lin Cheng; Shideng Bao; Jeremy N Rich
Journal:  Biochem Pharmacol       Date:  2010-05-10       Impact factor: 5.858

Review 3.  Molecular genetics of neurological tumours.

Authors:  R Y Chung; B R Seizinger
Journal:  J Med Genet       Date:  1992-06       Impact factor: 6.318

Review 4.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

5.  A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists.

Authors:  Venugopal Chenna; Chaoxin Hu; Dipankar Pramanik; Blake T Aftab; Collins Karikari; Nathaniel R Campbell; Seung-Mo Hong; Ming Zhao; Michelle A Rudek; Saeed R Khan; Charles M Rudin; Anirban Maitra
Journal:  Mol Cancer Ther       Date:  2011-10-25       Impact factor: 6.261

6.  The GLI gene encodes a nuclear protein which binds specific sequences in the human genome.

Authors:  K W Kinzler; B Vogelstein
Journal:  Mol Cell Biol       Date:  1990-02       Impact factor: 4.272

7.  A gene that encodes a protein consisting solely of zinc finger domains is preferentially expressed in transformed mouse cells.

Authors:  M Ernoult-Lange; M Kress; D Hamer
Journal:  Mol Cell Biol       Date:  1990-01       Impact factor: 4.272

8.  GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity.

Authors:  J M Ruppert; B Vogelstein; K Arheden; K W Kinzler
Journal:  Mol Cell Biol       Date:  1990-10       Impact factor: 4.272

9.  Loss of heterozygosity for DNA polymorphisms mapping to chromosomes 10 and 17 and prognosis in patients with gliomas.

Authors:  C E Jones; M B Davis; J L Darling; J F Geddes; D G Thomas; A E Harding
Journal:  J Neurol Neurosurg Psychiatry       Date:  1995-02       Impact factor: 10.154

10.  Detection of N-myc gene amplification by fluorescence in situ hybridization. Diagnostic utility for neuroblastoma.

Authors:  D N Shapiro; M B Valentine; S T Rowe; A E Sinclair; J E Sublett; W M Roberts; A T Look
Journal:  Am J Pathol       Date:  1993-05       Impact factor: 4.307
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