Literature DB >> 6462235

Malignant transformation of early passage rodent cells by a single mutated human oncogene.

D A Spandidos, N M Wilkie.   

Abstract

When linked to transcriptional enhancers, the mutant Ha-ras-1 gene from the T24 bladder carcinoma cell line induces the complete malignant transformation of early passage cells, while the normal Ha-ras-1 proto-oncogene only induces immortalization. Therefore, mutated Ha-ras-1 does not require a cooperating gene to trigger malignant conversion and ras genes may be involved in the process of tumorigenesis at an earlier stage than previously suspected.

Entities:  

Mesh：

Year:  1984        PMID： 6462235     DOI： 10.1038/310469a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  115 in total

1.  Dominant transformation by mutated human ras genes in vitro requires more than 100 times higher expression than is observed in cancers.

Authors:  V Y Hua; W K Wang; P H Duesberg
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-02       Impact factor: 11.205

2.  Growth advantage by overexpression of normal Harvey ras proto-oncogene in cultured rat epidermal keratinocytes.

Authors:  K Yamanishi; F M Liew; Y Hosokawa; S Kishimoto; H Yasuno
Journal:  Arch Dermatol Res       Date:  1990       Impact factor: 3.017

3.  Quantitation of mRNA and protein products of the Ha-ras-1 proto-oncogene.

Authors:  R Gambari; P Giacomini
Journal:  Breast Cancer Res Treat       Date:  1990-10       Impact factor: 4.872

4.  Depletion of c-myc with specific antisense sequences reverses the transformed phenotype in ras oncogene-transformed NIH 3T3 cells.

Authors:  M D Sklar; E Thompson; M J Welsh; M Liebert; J Harney; H B Grossman; M Smith; E V Prochownik
Journal:  Mol Cell Biol       Date:  1991-07       Impact factor: 4.272

5.  Malignant transformation of human fibroblasts caused by expression of a transfected T24 HRAS oncogene.

Authors:  P J Hurlin; V M Maher; J J McCormick
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

6.  Mutation of the Gs protein alpha subunit NH2 terminus relieves an attenuator function, resulting in constitutive adenylyl cyclase stimulation.

Authors:  S Osawa; L E Heasley; N Dhanasekaran; S K Gupta; C W Woon; C Berlot; G L Johnson
Journal:  Mol Cell Biol       Date:  1990-06       Impact factor: 4.272

7.  Coordinated expression of intermediate biomarkers for tumorigenic transformation in RAS-transfected mouse mammary epithelial cells.

Authors:  N T Telang; R Narayanan; H L Bradlow; M P Osborne
Journal:  Breast Cancer Res Treat       Date:  1991-08       Impact factor: 4.872

8.  Development of transforming function during transduction of proto-ras into Harvey sarcoma virus.

Authors:  M Lang; I Treinies; P H Duesberg; R Kurth; K Cichutek
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-18       Impact factor: 11.205

9.  Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-kappaB.

Authors:  Hiroyuki Mutoh; Hiroko Hayakawa; Hirotsugu Sakamoto; Kentaro Sugano
Journal:  J Gastroenterol       Date:  2007-09-25       Impact factor: 7.527

10.  Oncogenic capacity of the E2F1 gene.

Authors:  D G Johnson; W D Cress; L Jakoi; J R Nevins
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.