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Literature DB >> 18218837

Wnt/beta-catenin inhibits dental pulp stem cell differentiation.

Abstract

Dental pulp stem cells (DPSCs) are a unique precursor population isolated from postnatal human dental pulp and have the ability to regenerate a reparative dentin-like complex. Canonical Wnt signaling plays a critical role in tooth development and stem cell self-renewal through beta-catenin. In this study, the regulation of odontoblast-like differentiation of DPSCs by canonical Wnt signaling was examined. DPSCs were stably transduced with canonical Wnt-1 or the active form of beta-catenin, with retrovirus-mediated infection. Northern blot analysis found that Wnt-1 strongly induced the expression of matricellular protein osteopontin, and modestly enhanced the expression of type I collagen in DPSCs. Unexpectedly, Wnt-1 inhibited alkaline phosphatase (ALP) activity and the formation of mineralized nodules in DPSCs. Moreover, over-expression of beta-catenin was also sufficient to suppress the differentiation and mineralization of DPSCs. In conclusion, our results suggest that canonical Wnt signaling negatively regulates the odontoblast-like differentiation of DPSCs.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2008 PMID： 18218837 PMCID： PMC2906770 DOI： 10.1177/154405910808700206

Source DB: PubMed Journal: J Dent Res ISSN： 0022-0345 Impact factor: 6.116

25 in total

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Authors: S Gronthos; M Mankani; J Brahim; P G Robey; S Shi
Journal: Proc Natl Acad Sci U S A Date: 2000-12-05 Impact factor: 11.205

2. Stem cell properties of human dental pulp stem cells.

Authors: S Gronthos; J Brahim; W Li; L W Fisher; N Cherman; A Boyde; P DenBesten; P Gehron Robey; S Shi
Journal: J Dent Res Date: 2002-08 Impact factor: 6.116

3. Multilineage differentiation potential of stem cells derived from human dental pulp after cryopreservation.

Authors: Weibo Zhang; X Frank Walboomers; Songtao Shi; Mingwen Fan; John A Jansen
Journal: Tissue Eng Date: 2006-10

4. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.

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Journal: Cell Date: 2001-11-16 Impact factor: 41.582

5. High bone density due to a mutation in LDL-receptor-related protein 5.

Authors: Lynn M Boyden; Junhao Mao; Joseph Belsky; Lyle Mitzner; Anita Farhi; Mary A Mitnick; Dianqing Wu; Karl Insogna; Richard P Lifton
Journal: N Engl J Med Date: 2002-05-16 Impact factor: 91.245

6. Nuclear factor-kappa B-inducible death effector domain-containing protein suppresses tumor necrosis factor-mediated apoptosis by inhibiting caspase-8 activity.

Authors: Z You; H Ouyang; D Lopatin; P J Polver; C Y Wang
Journal: J Biol Chem Date: 2001-05-09 Impact factor: 5.157

7. Osteopontin deficiency increases mineral content and mineral crystallinity in mouse bone.

Authors: A L Boskey; L Spevak; E Paschalis; S B Doty; M D McKee
Journal: Calcif Tissue Int Date: 2002-06-20 Impact factor: 4.333

8. The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and TNF-mediated NF-kappa B activation through inhibiting phosphorylation of the I-kappa B kinase beta activation loop.

Authors: Fan Yang; Junro Yamashita; Eric Tang; Hom-Lay Wang; Kunliang Guan; Cun-Yu Wang
Journal: J Immunol Date: 2004-02-15 Impact factor: 5.422

9. FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice.

Authors: Klaus Kratochwil; Juan Galceran; Sabine Tontsch; Wera Roth; Rudolf Grosschedl
Journal: Genes Dev Date: 2002-12-15 Impact factor: 11.361

10. Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis.

Authors: Zongbing You; Daniel Saims; Shaoqiong Chen; Zhaocheng Zhang; Denis C Guttridge; Kun-Liang Guan; Ormond A MacDougald; Anthony M C Brown; Gerard Evan; Jan Kitajewski; Cun-Yu Wang
Journal: J Cell Biol Date: 2002-04-29 Impact factor: 10.539

39 in total

1. Lipoprotein Receptor-related Protein 6 Signaling is Necessary for Vasculogenic Differentiation of Human Dental Pulp Stem Cells.

Authors: Gleyce O Silva; Zhaocheng Zhang; Carolina Cucco; Min Oh; Carlos H R Camargo; Jacques E Nör
Journal: J Endod Date: 2017-08-01 Impact factor: 4.171

2. Effects of Wnt/β-catenin signalling on proliferation and differentiation of apical papilla stem cells.

Authors: J Wang; B Liu; S Gu; J Liang
Journal: Cell Prolif Date: 2012-01-30 Impact factor: 6.831

Review 3. Tissue engineering: from research to dental clinics.

Authors: Vinicius Rosa; Alvaro Della Bona; Bruno Neves Cavalcanti; Jacques Eduardo Nör
Journal: Dent Mater Date: 2012-01-10 Impact factor: 5.304

4. Mutations in WNT10B Are Identified in Individuals with Oligodontia.

Authors: Ping Yu; Wenli Yang; Dong Han; Xi Wang; Sen Guo; Jinchen Li; Fang Li; Xiaoxia Zhang; Sing-Wai Wong; Baojing Bai; Yao Liu; Jie Du; Zhong Sheng Sun; Songtao Shi; Hailan Feng; Tao Cai
Journal: Am J Hum Genet Date: 2016-06-16 Impact factor: 11.025

5. Effects of Btbd7 knockdown on the proliferation of human dental pulp cells and expression of Dspp.

Authors: Qi Bao; Jun Zhang; Xu-Xia Wang
Journal: Int J Clin Exp Pathol Date: 2018-03-01

6. Lymphocyte enhancer-binding factor 1: an essential factor in odontoblastic differentiation of dental pulp cells enzymatically isolated from rat incisors.

Authors: Satoshi Yokose; Takahiro Naka
Journal: J Bone Miner Metab Date: 2010-04-28 Impact factor: 2.626