Literature DB >> 18199783

Increasing prevalence of toxin A-negative, toxin B-positive isolates of Clostridium difficile in Korea: impact on laboratory diagnosis.

Heejung Kim1, Thomas V Riley, Myungsook Kim, Chang Ki Kim, Dongeun Yong, Kyungwon Lee, Yunsop Chong, Jong-Woo Park.   

Abstract

Of 462 Korean Clostridium difficile isolates, 77.5% were toxin B positive but 21.4% were toxin A negative (A(-) B(+)). The binary toxin gene was detected in nine isolates. A higher fluoroquinolone resistance of A(-) B(+) strains may contribute to the increase of these strains. Toxin A detection alone may underdiagnose C. difficile-associated disease.

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Year:  2008        PMID： 18199783      PMCID： PMC2268382          DOI： 10.1128/JCM.01188-07

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  14 in total

1.  Community-acquired Clostridium difficile diarrhea caused by binary toxin, toxin A, and toxin B gene-positive isolates in Hungary.

Authors:  Gabriella Terhes; Edit Urbán; József Sóki; Kanjo Abdul Hamid; Elisabeth Nagy
Journal:  J Clin Microbiol       Date:  2004-09       Impact factor: 5.948

2.  An epidemic, toxin gene-variant strain of Clostridium difficile.

Authors:  L Clifford McDonald; George E Killgore; Angela Thompson; Robert C Owens; Sophia V Kazakova; Susan P Sambol; Stuart Johnson; Dale N Gerding
Journal:  N Engl J Med       Date:  2005-12-01       Impact factor: 91.245

3.  High-level resistance to moxifloxacin and gatifloxacin associated with a novel mutation in gyrB in toxin-A-negative, toxin-B-positive Clostridium difficile.

Authors:  Denise Drudy; Teresa Quinn; Rebecca O'Mahony; Lorraine Kyne; Peadar O'Gaora; Séamus Fanning
Journal:  J Antimicrob Chemother       Date:  2006-10-03       Impact factor: 5.790

4.  New types of toxin A-negative, toxin B-positive strains among Clostridium difficile isolates from Asia.

Authors:  Maja Rupnik; Naoki Kato; Miklavz Grabnar; Haru Kato
Journal:  J Clin Microbiol       Date:  2003-03       Impact factor: 5.948

5.  Prevalence and genetic characterization of toxin A variant strains of Clostridium difficile among adults and children with diarrhea in France.

Authors:  Frédéric Barbut; Valérie Lalande; Béatrice Burghoffer; Huong Vu Thien; Emmanuel Grimprel; Jean-Claude Petit
Journal:  J Clin Microbiol       Date:  2002-06       Impact factor: 5.948

6.  [Characterization of a Toxin A-Negative, Toxin B-Positive Variant Strain of Clostridium difficile.].

Authors:  Bo Moon Shin; Eun Young Kuak
Journal:  Korean J Lab Med       Date:  2006-02

7.  Distribution of Clostridium difficile variant toxinotypes and strains with binary toxin genes among clinical isolates in an American hospital.

Authors:  Barbara Geric; Maja Rupnik; Dale N Gerding; Miklavz Grabnar; Stuart Johnson
Journal:  J Med Microbiol       Date:  2004-09       Impact factor: 2.472

8.  Prevalence and characterization of a binary toxin (actin-specific ADP-ribosyltransferase) from Clostridium difficile.

Authors:  Carina Gonçalves; Dominique Decré; Frédéric Barbut; Béatrice Burghoffer; Jean-Claude Petit
Journal:  J Clin Microbiol       Date:  2004-05       Impact factor: 5.948

9.  Actin-specific ADP-ribosyltransferase produced by a Clostridium difficile strain.

Authors:  M R Popoff; E J Rubin; D M Gill; P Boquet
Journal:  Infect Immun       Date:  1988-09       Impact factor: 3.441

10.  Identification of toxin A-negative, toxin B-positive Clostridium difficile by PCR.

Authors:  H Kato; N Kato; K Watanabe; N Iwai; H Nakamura; T Yamamoto; K Suzuki; S M Kim; Y Chong; E B Wasito
Journal:  J Clin Microbiol       Date:  1998-08       Impact factor: 5.948
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  29 in total

Review 1.  Laboratory diagnosis of bacterial gastroenteritis.

Authors:  Romney M Humphries; Andrea J Linscott
Journal:  Clin Microbiol Rev       Date:  2015-01       Impact factor: 26.132

2.  A human gut ecosystem protects against C. difficile disease by targeting TcdA.

Authors:  Sarah Lynn Martz; Mabel Guzman-Rodriguez; Shu-Mei He; Curtis Noordhof; David John Hurlbut; Gregory Brian Gloor; Christian Carlucci; Scott Weese; Emma Allen-Vercoe; Jun Sun; Erika Chiong Claud; Elaine Olga Petrof
Journal:  J Gastroenterol       Date:  2016-06-21       Impact factor: 7.527

3.  Evolutionary dynamics of Clostridium difficile over short and long time scales.

Authors:  Miao He; Mohammed Sebaihia; Trevor D Lawley; Richard A Stabler; Lisa F Dawson; Melissa J Martin; Kathryn E Holt; Helena M B Seth-Smith; Michael A Quail; Richard Rance; Karen Brooks; Carol Churcher; David Harris; Stephen D Bentley; Christine Burrows; Louise Clark; Craig Corton; Vicky Murray; Graham Rose; Scott Thurston; Andries van Tonder; Danielle Walker; Brendan W Wren; Gordon Dougan; Julian Parkhill
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-05       Impact factor: 11.205

Review 4.  The changing epidemiology of Clostridium difficile infections.

Authors:  J Freeman; M P Bauer; S D Baines; J Corver; W N Fawley; B Goorhuis; E J Kuijper; M H Wilcox
Journal:  Clin Microbiol Rev       Date:  2010-07       Impact factor: 26.132

Review 5.  Diagnosis of Clostridium difficile infection: an ongoing conundrum for clinicians and for clinical laboratories.

Authors:  Carey-Ann D Burnham; Karen C Carroll
Journal:  Clin Microbiol Rev       Date:  2013-07       Impact factor: 26.132

Review 6.  Variations in virulence and molecular biology among emerging strains of Clostridium difficile.

Authors:  Jonathan J Hunt; Jimmy D Ballard
Journal:  Microbiol Mol Biol Rev       Date:  2013-12       Impact factor: 11.056

7.  Evaluation of tcdB real-time PCR in a three-step diagnostic algorithm for detection of toxigenic Clostridium difficile.

Authors:  Ann M Larson; Angela M Fung; Ferric C Fang
Journal:  J Clin Microbiol       Date:  2009-11-18       Impact factor: 5.948

8.  Investigation of toxin gene diversity and antimicrobial resistance of Clostridium difficile strains.

Authors:  Shanshan Zhu; Huaping Zhang; Xinsheng Zhang; Chao Wang; Guangming Fan; Weifeng Zhang; Gang Sun; Huihong Chen; Liming Zhang; Zhaoyun Li
Journal:  Biomed Rep       Date:  2014-07-08

9.  Distinctive profiles of infection and pathology in hamsters infected with Clostridium difficile strains 630 and B1.

Authors:  David Goulding; Harold Thompson; Jenny Emerson; Neil F Fairweather; Gordon Dougan; Gill R Douce
Journal:  Infect Immun       Date:  2009-09-14       Impact factor: 3.441

10.  Comparison of polymerase chain reaction ribotyping, toxinotyping and nutritional aspects of toxin production of Clostridium difficile strains.

Authors:  Shanshan Zhu; Liming Zhang; Chunling Zhang; Xianjun Chen; Qi Chen; Zhaoyun Li
Journal:  Biomed Rep       Date:  2014-04-25
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