| Literature DB >> 18182300 |
Lidia Matesic1, Julie M Locke, John B Bremner, Stephen G Pyne, Danielle Skropeta, Marie Ranson, Kara L Vine.
Abstract
A range of N-phenethyl, N-phenacyl, and N-(1- and 2-naphthylmethyl) derivatives of 5,7-dibromoisatin 2 were prepared by N-alkylation reactions. Their activity against human monocyte-like histiocytic lymphoma (U937), leukemia (Jurkat), and breast carcinoma (MDA-MB-231) cell lines was assessed. The results allowed further development of structure-activity relationships. The compound 5,7-dibromo-N-(1-naphthylmethyl)-1H-indole-2,3-dione 5a was the most potent against U937 cells with an IC(50) value of 0.19 microM.Entities:
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Year: 2008 PMID： 18182300 DOI： 10.1016/j.bmc.2007.12.026
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641