OBJECTIVE: The aim of this study was to compare the diagnostic accuracy of myocardial perfusion imaging (MPI) by positron emission tomography (PET) with the diagnostic accuracy of MPI by single photon emission computed tomography (SPECT) in two comparable patient cohorts, using coronary angiography (CA) as the standard of reference. METHODS: A "SPECT-group" of 80 patients (15 female, 65 male; mean age 60+/-9 years) and a "PET-group" of 70 patients (14 female, 56 male; mean age 57+/-10 years) underwent a one day stress/rest examination either with attenuation-corrected (13)N-ammonia PET or attenuation-corrected (201)TlCl SPECT or (99m)Tc-hexakis-methoxy-isobutyl-isonitril (MIBI) SPECT. PET and SPECT results were semiquantitatively graded using a 6-segment heart model. All patients underwent CA, and stenoses were graded as a diameter reduction >or=50%. RESULTS: Coronary findings between both groups did not significantly differ at CA. For the SPECT-group overall sensitivity and specificity for localisation of stenoses was 77% and 84%. Respective values for the PET-group were 97% and 84%. The specificity of MPI by SPECT in the detection of ischemia was 74% and 91% for MPI by PET. The diagnostic accuracy of MPI improves when the individual coronary dominance and previous coronary revascularisations are taken into account. CONCLUSION: MPI by (13)N-ammonia PET is more sensitive in the detection and localisation of coronary stenoses, and more specific in the detection of ischemia than MPI by (201)TlCl/(99m)MIBI SPECT.
OBJECTIVE: The aim of this study was to compare the diagnostic accuracy of myocardial perfusion imaging (MPI) by positron emission tomography (PET) with the diagnostic accuracy of MPI by single photon emission computed tomography (SPECT) in two comparable patient cohorts, using coronary angiography (CA) as the standard of reference. METHODS: A "SPECT-group" of 80 patients (15 female, 65 male; mean age 60+/-9 years) and a "PET-group" of 70 patients (14 female, 56 male; mean age 57+/-10 years) underwent a one day stress/rest examination either with attenuation-corrected (13)N-ammonia PET or attenuation-corrected (201)TlCl SPECT or (99m)Tc-hexakis-methoxy-isobutyl-isonitril (MIBI) SPECT. PET and SPECT results were semiquantitatively graded using a 6-segment heart model. All patients underwent CA, and stenoses were graded as a diameter reduction >or=50%. RESULTS: Coronary findings between both groups did not significantly differ at CA. For the SPECT-group overall sensitivity and specificity for localisation of stenoses was 77% and 84%. Respective values for the PET-group were 97% and 84%. The specificity of MPI by SPECT in the detection of ischemia was 74% and 91% for MPI by PET. The diagnostic accuracy of MPI improves when the individual coronary dominance and previous coronary revascularisations are taken into account. CONCLUSION: MPI by (13)N-ammonia PET is more sensitive in the detection and localisation of coronary stenoses, and more specific in the detection of ischemia than MPI by (201)TlCl/(99m)MIBI SPECT.
Authors: W G Austen; J E Edwards; R L Frye; G G Gensini; V L Gott; L S Griffith; D C McGoon; M L Murphy; B B Roe Journal: Circulation Date: 1975-04 Impact factor: 29.690
Authors: Riemer H J A Slart; Jeroen J Bax; Dirk J van Veldhuisen; Ernst E van der Wall; Rudi A J O Dierckx; Pieter L Jager Journal: Int J Cardiovasc Imaging Date: 2005-12-13 Impact factor: 2.357
Authors: Yasmin Masood; Yi-Hwa Liu; Gordon Depuey; Raymond Taillefer; Luis I Araujo; Steven Allen; Dominique Delbeke; Frank Anstett; Aharon Peretz; Mary-Jo Zito; Vera Tsatkin; Frans J Th Wackers Journal: J Nucl Cardiol Date: 2005 Nov-Dec Impact factor: 5.952
Authors: R E Stewart; M Schwaiger; E Molina; J Popma; G M Gacioch; M Kalus; S Squicciarini; Z R al-Aouar; A Schork; D E Kuhl Journal: Am J Cardiol Date: 1991-06-15 Impact factor: 2.778
Authors: D S Berman; H Kiat; J D Friedman; F P Wang; K van Train; L Matzer; J Maddahi; G Germano Journal: J Am Coll Cardiol Date: 1993-11-01 Impact factor: 24.094
Authors: Pascal Koepfli; Christophe A Wyss; Mehdi Namdar; Michael Klainguti; Gustav K von Schulthess; Thomas F Lüscher; Philipp A Kaufmann Journal: J Nucl Med Date: 2004-10 Impact factor: 10.057
Authors: Gary V Heller; Timothy M Bateman; Lynne L Johnson; S James Cullom; James A Case; James R Galt; Ernest V Garcia; Keith Haddock; Kelly L Moutray; Carlos Poston; Eli H Botvinick; Matthews B Fish; William P Follansbee; Sean Hayes; Ami E Iskandrian; John J Mahmarian; William Vandecker Journal: J Nucl Cardiol Date: 2004 May-Jun Impact factor: 5.952
Authors: Timothy M Bateman; Gary V Heller; A Iain McGhie; John D Friedman; James A Case; Jan R Bryngelson; Ginger K Hertenstein; Kelly L Moutray; Kimberly Reid; S James Cullom Journal: J Nucl Cardiol Date: 2006 Jan-Feb Impact factor: 5.952
Authors: Mark D Bartholomä; Huamei He; Christina A Pacak; Patricia Dunning; Frederic H Fahey; Francis X McGowan; Douglas B Cowan; S Ted Treves; Alan B Packard Journal: Nucl Med Biol Date: 2013-09-04 Impact factor: 2.408
Authors: Kevin A Bybee; John Lee; Richard Markiewicz; Ryan Longmore; A Iain McGhie; James H O'Keefe; Bai-Ling Hsu; Kevin Kennedy; Randall C Thompson; Timothy M Bateman Journal: J Nucl Cardiol Date: 2009-12-11 Impact factor: 5.952