Literature DB >> 18058549

Molecular modelling studies on the binding of some protides to the putative human phosphoramidase Hint1.

C Congiatu1, A Brancale, C McGuigan.   

Abstract

The aim of the present work is to investigate through molecular modelling the possible role of the human enzyme Hint1 in the final P-N bond cleavage of phosphoramidate ProTides, which would lead to the intracellular delivery of unmasked nucleoside analogue monophosphates. Herein, we report our preliminary analysis based on docking studies of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdU) related aminoacyl phosphates with Hint1 and the effect of the amino acid moiety on the enzyme-substrate binding affinity.

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Year:  2007        PMID： 18058549     DOI： 10.1080/15257770701521656

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN： 1525-7770            Impact factor:   1.381


  8 in total

Review 1.  Synthesis of nucleoside phosphate and phosphonate prodrugs.

Authors:  Ugo Pradere; Ethel C Garnier-Amblard; Steven J Coats; Franck Amblard; Raymond F Schinazi
Journal:  Chem Rev       Date:  2014-08-21       Impact factor: 60.622

2.  Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues.

Authors:  Andrea Lisco; Christophe Vanpouille; Egor P Tchesnokov; Jean-Charles Grivel; Angélique Biancotto; Beda Brichacek; Julie Elliott; Emilie Fromentin; Robin Shattock; Peter Anton; Robert Gorelick; Jan Balzarini; Christopher McGuigan; Marco Derudas; Matthias Götte; Raymond F Schinazi; Leonid Margolis
Journal:  Cell Host Microbe       Date:  2008-09-11       Impact factor: 21.023

3.  Kinetin Riboside and Its ProTides Activate the Parkinson's Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization.

Authors:  Laura Osgerby; Yu-Chiang Lai; Peter J Thornton; Joseph Amalfitano; Cécile S Le Duff; Iqra Jabeen; Hachemi Kadri; Ageo Miccoli; James H R Tucker; Miratul M K Muqit; Youcef Mehellou
Journal:  J Med Chem       Date:  2017-03-28       Impact factor: 7.446

Review 4.  Phosphoramidates and phosphonamidates (ProTides) with antiviral activity.

Authors:  Magdalena Slusarczyk; Michaela Serpi; Fabrizio Pertusati
Journal:  Antivir Chem Chemother       Date:  2018 Jan-Dec

Review 5.  Overcoming cancer therapeutic bottleneck by drug repurposing.

Authors:  Zhe Zhang; Li Zhou; Na Xie; Edouard C Nice; Tao Zhang; Yongping Cui; Canhua Huang
Journal:  Signal Transduct Target Ther       Date:  2020-07-02

6.  Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin.

Authors:  Marco Derudas; Andrea Brancale; Lieve Naesens; Johan Neyts; Jan Balzarini; Christopher McGuigan
Journal:  Bioorg Med Chem       Date:  2010-02-15       Impact factor: 3.641

7.  Phosphoramidates of 2'-beta-D-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism.

Authors:  Youcef Mehellou; Rocco Valente; Huw Mottram; Elisabeth Walsby; Kenneth I Mills; Jan Balzarini; Christopher McGuigan
Journal:  Bioorg Med Chem       Date:  2010-03-01       Impact factor: 3.641

8.  Aryloxy Diester Phosphonamidate Prodrugs of Phosphoantigens (ProPAgens) as Potent Activators of Vγ9/Vδ2 T-Cell Immune Responses.

Authors:  Hachemi Kadri; Taher E Taher; Qin Xu; Maria Sharif; Elizabeth Ashby; Richard T Bryan; Benjamin E Willcox; Youcef Mehellou
Journal:  J Med Chem       Date:  2020-09-29       Impact factor: 7.446
  8 in total

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