Literature DB >> 25144792

Synthesis of nucleoside phosphate and phosphonate prodrugs.

Ugo Pradere1, Ethel C Garnier-Amblard, Steven J Coats, Franck Amblard, Raymond F Schinazi.   

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Year:  2014        PMID： 25144792      PMCID： PMC4173794          DOI： 10.1021/cr5002035

Source DB:  PubMed          Journal:  Chem Rev        ISSN： 0009-2665            Impact factor:   60.622


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  299 in total

1.  Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA.

Authors:  C Ballatore; C McGuigan; E De Clercq; J Balzarini
Journal:  Bioorg Med Chem Lett       Date:  2001-04-23       Impact factor: 2.823

2.  Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.

Authors:  Christopher McGuigan; Arnaud Gilles; Karolina Madela; Mohamed Aljarah; Sabrina Holl; Sarah Jones; John Vernachio; Jeff Hutchins; Brenda Ames; K Dawn Bryant; Elena Gorovits; Babita Ganguly; Damound Hunley; Andrea Hall; Alexander Kolykhalov; Yule Liu; Jerry Muhammad; Nicholas Raja; Robin Walters; Jin Wang; Stanley Chamberlain; Geoffrey Henson
Journal:  J Med Chem       Date:  2010-07-08       Impact factor: 7.446

Review 3.  HepDirect prodrugs for targeting nucleotide-based antiviral drugs to the liver.

Authors:  Mark D Erion; David A Bullough; Chin-Chung Lin; Zhi Hong
Journal:  Curr Opin Investig Drugs       Date:  2006-02

4.  Phosphoramidate derivatives of d4T as inhibitors of HIV: the effect of amino acid variation.

Authors:  C McGuigan; H W Tsang; D Cahard; K Turner; S Velazquez; A Salgado; L Bidois; L Naesens; E De Clercq; J Balzarini
Journal:  Antiviral Res       Date:  1997-08       Impact factor: 5.970

5.  Comparison of the antiviral activities of alkoxyalkyl and alkyl esters of cidofovir against human and murine cytomegalovirus replication in vitro.

Authors:  William B Wan; James R Beadle; Caroll Hartline; Earl R Kern; Stephanie L Ciesla; Nadejda Valiaeva; Karl Y Hostetler
Journal:  Antimicrob Agents Chemother       Date:  2005-02       Impact factor: 5.191

6.  Application of phosphoramidate ProTide technology significantly improves antiviral potency of carbocyclic adenosine derivatives.

Authors:  Christopher McGuigan; Alshaimaa Hassan-Abdallah; Sheila Srinivasan; Yikang Wang; Adam Siddiqui; Susan M Daluge; Kristjan S Gudmundsson; Huiqiang Zhou; Ed W McLean; Jennifer P Peckham; Thimysta C Burnette; Harry Marr; Richard Hazen; Lynn D Condreay; Lance Johnson; Jan Balzarini
Journal:  J Med Chem       Date:  2006-11-30       Impact factor: 7.446

7.  Design and synthesis of novel bis(L-amino acid) ester prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) with improved anti-HBV activity.

Authors:  Xiaozhong Fu; Saihong Jiang; Chuan Li; Jian Xin; Yushe Yang; Ruyun Ji
Journal:  Bioorg Med Chem Lett       Date:  2006-10-12       Impact factor: 2.823

8.  Synthesis and biological properties of some cyclic phosphotriesters derived from 2'-deoxy-5-fluorouridine.

Authors:  R N Hunston; A S Jones; C McGuigan; R T Walker; J Balzarini; E De Clercq
Journal:  J Med Chem       Date:  1984-04       Impact factor: 7.446

9.  Nucleoside conjugates. 11. Synthesis and antitumor activity of 1-beta-D-arabinofuranosylcytosine and cytidine conjugates of thioether lipids.

Authors:  C I Hong; A J Kirisits; A Nechaev; D J Buchheit; C R West
Journal:  J Med Chem       Date:  1990-05       Impact factor: 7.446

10.  The phosphoramidate ProTide approach greatly enhances the activity of beta-2'-C-methylguanosine against hepatitis C virus.

Authors:  Christopher McGuigan; Plinio Perrone; Karolina Madela; Johan Neyts
Journal:  Bioorg Med Chem Lett       Date:  2009-06-10       Impact factor: 2.823
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  81 in total

1.  Design, Synthesis, and Anti-HBV Activity of New Bis(l-amino acid) Ester Tenofovir Prodrugs.

Authors:  Apeng Wang; Shuo Wu; Zeyu Tao; Xiaoning Li; Kai Lv; Chao Ma; Yuhuan Li; Linhu Li; Mingliang Liu
Journal:  ACS Med Chem Lett       Date:  2019-05-16       Impact factor: 4.345

2.  Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs.

Authors:  Jong Hyun Cho; Lavanya Bondana; Mervi A Detorio; Cathy Montero; Leda C Bassit; Franck Amblard; Steven J Coats; Raymond F Schinazi
Journal:  Bioorg Med Chem       Date:  2014-10-13       Impact factor: 3.641

3.  Design and Synthesis of Fluorescent Acyclic Nucleoside Phosphonates as Potent Inhibitors of Bacterial Adenylate Cyclases.

Authors:  Petra Břehová; Markéta Šmídková; Jan Skácel; Martin Dračínský; Helena Mertlíková-Kaiserová; Monica P Soto Velasquez; Val J Watts; Zlatko Janeba
Journal:  ChemMedChem       Date:  2016-10-24       Impact factor: 3.466

Review 4.  Phosphonate prodrugs: an overview and recent advances.

Authors:  Kenneth M Heidel; Cynthia S Dowd
Journal:  Future Med Chem       Date:  2019-07       Impact factor: 3.808

5.  Synthesis of 7-benzylguanosine cap-analogue conjugates for eIF4E targeted degradation.

Authors:  Tanpreet Kaur; Arya Menon; Amanda L Garner
Journal:  Eur J Med Chem       Date:  2019-01-31       Impact factor: 6.514

6.  Reduction Sensitive Lipid Conjugates of Tenofovir: Synthesis, Stability, and Antiviral Activity.

Authors:  Kyle E Giesler; Jose Marengo; Dennis C Liotta
Journal:  J Med Chem       Date:  2016-07-22       Impact factor: 7.446

7.  Synthesis and Anti-HCV Activity of a Novel 2',3'-Dideoxy-2'-α-fluoro-2'-β-C-methyl Guanosine Phosphoramidate Prodrug.

Authors:  Wenquan Yu; Ertong Li; Zhigang Lv; Ke Liu; Xiaohe Guo; Yuan Liu; Junbiao Chang
Journal:  ACS Med Chem Lett       Date:  2017-05-01       Impact factor: 4.345

8.  Anchimerically Activatable Antiviral ProTides.

Authors:  Aniekan Okon; Marcos Romário Matos de Souza; Rachit Shah; Raquel Amorim; Luciana Jesus da Costa; Carston R Wagner
Journal:  ACS Med Chem Lett       Date:  2017-08-14       Impact factor: 4.345

9.  ω-Hydroxy isoprenoid bisphosphonates as linkable GGDPS inhibitors.

Authors:  Nazmul H Bhuiyan; Michelle L Varney; Deep S Bhattacharya; William M Payne; Aaron M Mohs; Sarah A Holstein; David F Wiemer
Journal:  Bioorg Med Chem Lett       Date:  2019-08-20       Impact factor: 2.823

10.  A Cyclic Phosphoramidate Prodrug of 2'-Deoxy-2'-Fluoro-2'-C-Methylguanosine for the Treatment of Dengue Virus Infection.

Authors:  Ratna Karuna; Fumiaki Yokokawa; Keshi Wang; Jin Zhang; Haoying Xu; Gang Wang; Mei Ding; Wai Ling Chan; Nahdiyah Abdul Ghafar; Andrea Leonardi; Cheah Chen Seh; Peck Gee Seah; Wei Liu; Rao P S Srinivasa; Siew Pheng Lim; Suresh B Lakshminarayana; Ellie Growcott; Sreehari Babu; Martijn Fenaux; Weidong Zhong; Feng Gu; Pei-Yong Shi; Francesca Blasco; Yen-Liang Chen
Journal:  Antimicrob Agents Chemother       Date:  2020-11-17       Impact factor: 5.191
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