Literature DB >> 18054225

Inhibiting dihydrodipicolinate synthase across species: towards specificity for pathogens?

Voula Mitsakos1, Renwick C J Dobson, F Grant Pearce, Sean R Devenish, Genevieve L Evans, Benjamin R Burgess, Matthew A Perugini, Juliet A Gerrard, Craig A Hutton.   

Abstract

Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis and an important antibiotic target. The specificity of a range of heterocyclic product analogues against DHDPS from three pathogenic species, Bacillus anthracis, Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus, and the evolutionarily related N-acetylneuraminate lyase, has been determined. The results suggest that the development of species-specific inhibitors of DHDPS as potential antibacterials is achievable.

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Year:  2007        PMID： 18054225     DOI： 10.1016/j.bmcl.2007.11.026

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

1.  Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the grapevine Vitis vinifera.

Authors:  Sarah C Atkinson; Con Dogovski; Janet Newman; Renwick C J Dobson; Matthew A Perugini
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2011-11-25

2.  Molecular Interaction of Novel Compound 2-Methylheptyl Isonicotinate Produced by Streptomyces sp. 201 with Dihydrodipicolinate Synthase (DHDPS) Enzyme of Mycobacterium tuberculosis for its Antibacterial Activity.

Authors:  Salam Pradeep Singh; T C Bora; R L Bezbaruah
Journal:  Indian J Microbiol       Date:  2012-02-05       Impact factor: 2.461

3.  Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from Agrobacterium tumefaciens.

Authors:  Sarah C Atkinson; Con Dogovski; Renwick C J Dobson; Matthew A Perugini
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2012-08-30

Review 4.  Molecular evolution of an oligomeric biocatalyst functioning in lysine biosynthesis.

Authors:  Tatiana P Soares da Costa; Belinda M Abbott; Anthony R Gendall; Santosh Panjikar; Matthew A Perugini
Journal:  Biophys Rev       Date:  2017-12-05

5.  Crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase 2 from Arabidopsis thaliana.

Authors:  Michael D W Griffin; Jagan M Billakanti; Juliet A Gerrard; Renwick C J Dobson; F Grant Pearce
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2011-10-27

6.  The purification, crystallization and preliminary X-ray diffraction analysis of two isoforms of meso-diaminopimelate decarboxylase from Arabidopsis thaliana.

Authors:  Michael R Oliver; Jennifer M Crowther; Mary M Leeman; Sarah A Kessans; Rachel A North; Katherine A Donovan; Michael D W Griffin; Hironori Suzuki; André O Hudson; Müge Kasanmascheff; Renwick C J Dobson
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2014-04-25       Impact factor: 1.056

7.  The high-resolution structure of dihydrodipicolinate synthase from Escherichia coli bound to its first substrate, pyruvate.

Authors:  Sean R A Devenish; Juliet A Gerrard; Geoffrey B Jameson; Renwick C J Dobson
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2008-11-28

8.  Conserved main-chain peptide distortions: a proposed role for Ile203 in catalysis by dihydrodipicolinate synthase.

Authors:  Renwick C J Dobson; Michael D W Griffin; Sean R A Devenish; F Grant Pearce; Craig A Hutton; Juliet A Gerrard; Geoffrey B Jameson; Matthew A Perugini
Journal:  Protein Sci       Date:  2008-09-11       Impact factor: 6.725

9.  Structural, kinetic and computational investigation of Vitis vinifera DHDPS reveals new insight into the mechanism of lysine-mediated allosteric inhibition.

Authors:  Sarah C Atkinson; Con Dogovski; Matthew T Downton; Peter E Czabotar; Renwick C J Dobson; Juliet A Gerrard; John Wagner; Matthew A Perugini
Journal:  Plant Mol Biol       Date:  2013-01-26       Impact factor: 4.076

10.  Purification, crystallization and preliminary X-ray diffraction studies to near-atomic resolution of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus.

Authors:  Benjamin R Burgess; Renwick C J Dobson; Con Dogovski; Geoffrey B Jameson; Michael W Parker; Matthew A Perugini
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2008-06-28
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