Literature DB >> 18007403

Preparation of 6-substituted quinoxaline JSP-1 inhibitors by microwave accelerated nucleophilic substitution.

Li Zhang1, Beiying Qiu, Xin Li, Xin Wang, Jingya Li, Yongliang Zhang, Jian Liu, Jia Li, Jingkang Shen.   

Abstract

A small library of 6-aminoquinoxalines has been prepared by nucleophilic substitution of 6-fluoroquinoxaline with amines and nitrogen-containing heterocycles under computer-controlled microwave irradiation. Some compounds were found to be potent inhibitors of JNK Stimulatory Phosphatase-1 (JSP-1) in an in vitro biological assay.

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Year:  2006        PMID： 18007403      PMCID： PMC6148675          DOI： 10.3390/11120988

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  24 in total

Review 1.  Microwave-enhanced medicinal chemistry: a high-speed opportunity for convenient preparation of protease inhibitors.

Authors:  Karolina Ersmark; Mats Larhed; Johan Wannberg
Journal:  Curr Opin Drug Discov Devel       Date:  2004-07

Review 2.  Microwave - assisted chemistry in drug discovery.

Authors:  Farah Mavandadi; Pelle Lidström
Journal:  Curr Top Med Chem       Date:  2004       Impact factor: 3.295

3.  Rhodanine derivatives as inhibitors of JSP-1.

Authors:  Neil S Cutshall; Christine O'Day; Marina Prezhdo
Journal:  Bioorg Med Chem Lett       Date:  2005-07-15       Impact factor: 2.823

4.  Hypoxia-selective agents derived from quinoxaline 1,4-di-N-oxides.

Authors:  A Monge; J A Palop; A López de Ceráin; V Senador; F J Martínez-Crespo; Y Sainz; S Narro; E García; C de Miguel; M González
Journal:  J Med Chem       Date:  1995-05-12       Impact factor: 7.446

5.  Quinoxaline N-oxide containing potent angiotensin II receptor antagonists: synthesis, biological properties, and structure-activity relationships.

Authors:  K S Kim; L Qian; J E Bird; K E Dickinson; S Moreland; T R Schaeffer; T L Waldron; C L Delaney; H N Weller; A V Miller
Journal:  J Med Chem       Date:  1993-08-06       Impact factor: 7.446

6.  Synthesis and AMPA receptor antagonistic activity of a novel class of quinoxalinecarboxylic acid with a substituted phenyl group at the C-7 position.

Authors:  Yasuo Takano; Futoshi Shiga; Jun Asano; Naoki Ando; Hideharu Uchiki; Tsuyosi Anraku
Journal:  Bioorg Med Chem Lett       Date:  2003-10-20       Impact factor: 2.823

7.  5-Aminomethylquinoxaline-2,3-diones. Part I: A novel class of AMPA receptor antagonists.

Authors:  Y P Auberson; S Bischoff; R Moretti; M Schmutz; S J Veenstra
Journal:  Bioorg Med Chem Lett       Date:  1998-01-06       Impact factor: 2.823

8.  An improved synthesis of 3,8-dimethyl-3H-imidazo[4,5-f]quinoxalin-2-amine ("MeIQx") and its 2-14C-labelled analogue.

Authors:  S Grivas; K Olsson
Journal:  Acta Chem Scand B       Date:  1985

9.  Quinoxaline chemistry. Part XVII. Methyl [4-(substituted 2-quinoxalinyloxy) phenyl] acetates and ethyl N-([4-(substituted 2-quinoxalinyloxy) phenyl] acetyl) glutamates analogs of methotrexate: synthesis and evaluation of in vitro anticancer activity.

Authors:  Sandra Piras; Mario Loriga; Giuseppe Paglietti
Journal:  Farmaco       Date:  2004-03

10.  One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation.

Authors:  Jian Li; Jing Chen; Li Zhang; Feng Wang; Chunshan Gui; Li Zhang; Yu Qin; Qiang Xu; Hong Liu; Fajun Nan; Jingkang Shen; Donglu Bai; Kaixian Chen; Xu Shen; Hualiang Jiang
Journal:  Bioorg Med Chem       Date:  2006-05-06       Impact factor: 3.641
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  1 in total

1.  Structural analysis of human dual-specificity phosphatase 22 complexed with a phosphotyrosine-like substrate.

Authors:  George T Lountos; Scott Cherry; Joseph E Tropea; David S Waugh
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2015-01-28       Impact factor: 1.056
  1 in total

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