Literature DB >> 15961311

Rhodanine derivatives as inhibitors of JSP-1.

Neil S Cutshall1, Christine O'Day, Marina Prezhdo.   

Abstract

Dual-specificity phosphatases (DSPs) are a subclass within the protein tyrosine phosphatase family (PTPs). A series of rhodanine-based inhibitors was synthesized and shown to be novel, potent, and selective inhibitors against the DSP family member JNK-stimulating phosphatase-1 (JSP-1). Compounds of this class may be useful for the treatment of inflammatory and proliferative disorders.

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Year:  2005        PMID： 15961311     DOI： 10.1016/j.bmcl.2005.05.034

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  24 in total

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4.  Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions.

Authors:  Paul A Jackson; John C Widen; Daniel A Harki; Kay M Brummond
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5.  Syntheses, in vitro, and in silico studies of rhodanine-based schiff bases as potential α-amylase inhibitors and radicals (DPPH and ABTS) scavengers.

Authors:  Samuel Attah Egu; Irfan Ali; Khalid Mohammed Khan; Sridevi Chigurupati; Urooj Qureshi; Uzma Salar; Muhammad Taha; Shatha Ghazi Felemban; Vijayan Venugopal; Zaheer Ul-Haq
Journal:  Mol Divers       Date:  2022-05-23       Impact factor: 2.943

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7.  Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis.

Authors:  N D Sonawane; A S Verkman
Journal:  Bioorg Med Chem       Date:  2008-07-23       Impact factor: 3.641

8.  Preparation of 6-substituted quinoxaline JSP-1 inhibitors by microwave accelerated nucleophilic substitution.

Authors:  Li Zhang; Beiying Qiu; Xin Li; Xin Wang; Jingya Li; Yongliang Zhang; Jian Liu; Jia Li; Jingkang Shen
Journal:  Molecules       Date:  2006-12-21       Impact factor: 4.411

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Journal:  Cell Host Microbe       Date:  2008-03-13       Impact factor: 21.023

10.  Synthesis of New N,N'-Bis(5-arylidene-4-oxo-4,5-dihydrothiazolin-2-yl)piperazine Derivatives Under Microwave Irradiation and Preliminary Biological Evaluation.

Authors:  Wacothon Karime Coulibaly; Ludovic Paquin; Anoubilé Bénié; Yves-Alain Bekro; Emilie Durieux; Laurent Meijer; Rémy Le Guével; Anne Corlu; Jean-Pierre Bazureau
Journal:  Sci Pharm       Date:  2012-09-16
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